An NGS-based assay for accurate detection and quantification of immune gene expression in mouse tumor models

Tumor microenvironment (TME) is a complex dynamic system with many tumor-interacting components including tumor-infiltrating leukocytes (TILs), cancer associated fibroblasts, blood vessels, and other stromal constituents. It intrinsically affects tumor development and pharmacology of oncology therap...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0303171-e0303171
Hauptverfasser:	Xue, Jia, Chen, Xiaobo, An, Xiaoyu, Wang, Jingjing, Zang, Mingfa, Mao, Binchen, Guo, Sheng, Yang, Tao, Kumari, Rajendra, Li, Qi-Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Bioinformatics Biological response modifiers Biology and life sciences Biomarkers Blood vessels Cancer Care and treatment CD4 antigen Cell Line, Tumor Diagnosis Disease Models, Animal DNA microarrays Female Flow cytometry Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Genes Genetic aspects Genomics High-Throughput Nucleotide Sequencing - methods Immune system Immunology Interferon Interferon-gamma - genetics Interferon-gamma - metabolism Laboratory animals Leukocytes Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Medical research Medicine and Health Sciences Medicine, Experimental Messenger RNA Mice Mice, Inbred C57BL Molecular diagnostic techniques Neoplasms - genetics Neoplasms - immunology Oncology PD-1 protein Pharmacodynamics Pharmacology Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Proteomics Research and Analysis Methods RNA sequencing RNA, Messenger - genetics Software Testing Tumor microenvironment Tumor Microenvironment - immunology Tumors γ-Interferon
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