Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis

First metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors' previous studies, medially posi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2024-05, Vol.19 (5), p.e0303752-e0303752
Hauptverfasser: Sabik, Agnieszka, Daszkiewicz, Karol, Witkowski, Wojciech, Łuczkiewicz, Piotr
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page e0303752
container_issue 5
container_start_page e0303752
container_title PloS one
container_volume 19
creator Sabik, Agnieszka
Daszkiewicz, Karol
Witkowski, Wojciech
Łuczkiewicz, Piotr
description First metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors' previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus for both placements of the locking plate. Two finite element models of the first metatarsophalangeal joint with the dorsally and medially positioned plate were defined in the Abaqus software to simulate differentiation of the fracture callus. A simplified load application, i.e. one single step per each day and the diffusion of the mesenchymal stem cells into the fracture region were assumed in an iterative hardening process. The changes of the mesenchymal stem cells into different phenotypes during the callus stiffening were governed by the octahedral shear strain and interstitial fluid velocity according to Prendergast mechanoregulation theory. Basing on the obtained results the progress of the cartilage and bone tissues formation and their distribution within the callus were compared between two models. The obtained results suggest that after 6 weeks of simulation the healing progress is in general comparable for both plates. However, earlier closing of external callus was observed for the medially positioned plate which had greater vertical bending stiffness. This process enables faster internal callus hardening and promotes symmetrical bridging.
doi_str_mv 10.1371/journal.pone.0303752
format Article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_3069288211</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A794065922</galeid><doaj_id>oai_doaj_org_article_9160d772552d40f98724a690159e9392</doaj_id><sourcerecordid>A794065922</sourcerecordid><originalsourceid>FETCH-LOGICAL-c642t-a12a46a1ed70f5131534bcc168d371c566db94f2bb46ec6844b83cf7f13ee3f83</originalsourceid><addsrcrecordid>eNqNk8tu1DAUhiMEoqXwBggsISFYzOBL4iRs0GjEpVKlSty2luPYEw-OndpOS9-KR8TppNUM6gJlEcf5_v9c7JNlzxFcIlKid1s3esvNcnBWLiGBpCzwg-wY1QQvKIbk4d76KHsSwhbCglSUPs6OSFXeLI-zP2vXD9zzqC8l4MnvOugAnAK9FB23WnADhLOtjtrZALQFTYoHRps-gXLGuCttN0BpH2LSRB65D27ouOF2I5N467SNgPvYedfKyfxKxw5ccq9lC4wTvyb9YHiUYHBhF-c9WCVLq9OeNLKXk8Oc29PskeImyGfz-yT78enj9_WXxdn559P16mwhaI7jgiPMc8qRbEuoCkRQQfJGCESrNjVPFJS2TZ0r3DQ5lYJWed5URKhSISIlURU5yV7ufAfjApubHRiBtMZVhRFKxOmOaB3fssHrnvtr5rhmNxvOb1gqWwsjWY0obMsSFwVuc6jqqsQ5pzVERS1rUuPk9WGONja9bEWq2HNzYHr4x-qObdwlQwjWVV4VyeHN7ODdxShDZL0OQpp0DtKNU-KpZoqKAib01T_o_eXN1IanCrRVLgUWkylblXUOaVHjKfHlPVR6WtnrdHGk0mn_QPD2QJCYKH_HDR9DYKffvv4_e_7zkH29x3bp6sUuODPe3KdDMN-BwrsQvFR3XUaQTZN12w02TRabJyvJXuyf0J3odpTIXy9_Idw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3069288211</pqid></control><display><type>article</type><title>Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Sabik, Agnieszka ; Daszkiewicz, Karol ; Witkowski, Wojciech ; Łuczkiewicz, Piotr</creator><contributor>Mehboob, Ali</contributor><creatorcontrib>Sabik, Agnieszka ; Daszkiewicz, Karol ; Witkowski, Wojciech ; Łuczkiewicz, Piotr ; Mehboob, Ali</creatorcontrib><description>First metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors' previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus for both placements of the locking plate. Two finite element models of the first metatarsophalangeal joint with the dorsally and medially positioned plate were defined in the Abaqus software to simulate differentiation of the fracture callus. A simplified load application, i.e. one single step per each day and the diffusion of the mesenchymal stem cells into the fracture region were assumed in an iterative hardening process. The changes of the mesenchymal stem cells into different phenotypes during the callus stiffening were governed by the octahedral shear strain and interstitial fluid velocity according to Prendergast mechanoregulation theory. Basing on the obtained results the progress of the cartilage and bone tissues formation and their distribution within the callus were compared between two models. The obtained results suggest that after 6 weeks of simulation the healing progress is in general comparable for both plates. However, earlier closing of external callus was observed for the medially positioned plate which had greater vertical bending stiffness. This process enables faster internal callus hardening and promotes symmetrical bridging.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0303752</identifier><identifier>PMID: 38753866</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Antiarthritic agents ; Arthrodesis ; Arthrodesis - methods ; Bending ; Biology and Life Sciences ; Biomechanical Phenomena ; Biomechanics ; Bone growth ; Bone Plates ; Bones ; Bony Callus ; Callus ; Cartilage ; Comparative analysis ; Diffusion rate ; Finite Element Analysis ; Finite element method ; Fracture Healing ; Fractures ; Humans ; Joints (anatomy) ; Locking ; Mathematical models ; Mechanical properties ; Medical treatment ; Medicine and Health Sciences ; Mesenchymal stem cells ; Metatarsophalangeal Joint - surgery ; Osteogenesis ; Phenotypes ; Physical Sciences ; Porous materials ; Shear strain ; Software ; Stem cells ; Stiffening ; Stiffness ; Velocity</subject><ispartof>PloS one, 2024-05, Vol.19 (5), p.e0303752-e0303752</ispartof><rights>Copyright: © 2024 Sabik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Sabik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Sabik et al 2024 Sabik et al</rights><rights>2024 Sabik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c642t-a12a46a1ed70f5131534bcc168d371c566db94f2bb46ec6844b83cf7f13ee3f83</cites><orcidid>0000-0001-5539-085X ; 0000-0003-2832-7892 ; 0000-0002-8732-8695</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098485/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098485/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38753866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mehboob, Ali</contributor><creatorcontrib>Sabik, Agnieszka</creatorcontrib><creatorcontrib>Daszkiewicz, Karol</creatorcontrib><creatorcontrib>Witkowski, Wojciech</creatorcontrib><creatorcontrib>Łuczkiewicz, Piotr</creatorcontrib><title>Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>First metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors' previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus for both placements of the locking plate. Two finite element models of the first metatarsophalangeal joint with the dorsally and medially positioned plate were defined in the Abaqus software to simulate differentiation of the fracture callus. A simplified load application, i.e. one single step per each day and the diffusion of the mesenchymal stem cells into the fracture region were assumed in an iterative hardening process. The changes of the mesenchymal stem cells into different phenotypes during the callus stiffening were governed by the octahedral shear strain and interstitial fluid velocity according to Prendergast mechanoregulation theory. Basing on the obtained results the progress of the cartilage and bone tissues formation and their distribution within the callus were compared between two models. The obtained results suggest that after 6 weeks of simulation the healing progress is in general comparable for both plates. However, earlier closing of external callus was observed for the medially positioned plate which had greater vertical bending stiffness. This process enables faster internal callus hardening and promotes symmetrical bridging.</description><subject>Analysis</subject><subject>Antiarthritic agents</subject><subject>Arthrodesis</subject><subject>Arthrodesis - methods</subject><subject>Bending</subject><subject>Biology and Life Sciences</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Bone growth</subject><subject>Bone Plates</subject><subject>Bones</subject><subject>Bony Callus</subject><subject>Callus</subject><subject>Cartilage</subject><subject>Comparative analysis</subject><subject>Diffusion rate</subject><subject>Finite Element Analysis</subject><subject>Finite element method</subject><subject>Fracture Healing</subject><subject>Fractures</subject><subject>Humans</subject><subject>Joints (anatomy)</subject><subject>Locking</subject><subject>Mathematical models</subject><subject>Mechanical properties</subject><subject>Medical treatment</subject><subject>Medicine and Health Sciences</subject><subject>Mesenchymal stem cells</subject><subject>Metatarsophalangeal Joint - surgery</subject><subject>Osteogenesis</subject><subject>Phenotypes</subject><subject>Physical Sciences</subject><subject>Porous materials</subject><subject>Shear strain</subject><subject>Software</subject><subject>Stem cells</subject><subject>Stiffening</subject><subject>Stiffness</subject><subject>Velocity</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk8tu1DAUhiMEoqXwBggsISFYzOBL4iRs0GjEpVKlSty2luPYEw-OndpOS9-KR8TppNUM6gJlEcf5_v9c7JNlzxFcIlKid1s3esvNcnBWLiGBpCzwg-wY1QQvKIbk4d76KHsSwhbCglSUPs6OSFXeLI-zP2vXD9zzqC8l4MnvOugAnAK9FB23WnADhLOtjtrZALQFTYoHRps-gXLGuCttN0BpH2LSRB65D27ouOF2I5N467SNgPvYedfKyfxKxw5ccq9lC4wTvyb9YHiUYHBhF-c9WCVLq9OeNLKXk8Oc29PskeImyGfz-yT78enj9_WXxdn559P16mwhaI7jgiPMc8qRbEuoCkRQQfJGCESrNjVPFJS2TZ0r3DQ5lYJWed5URKhSISIlURU5yV7ufAfjApubHRiBtMZVhRFKxOmOaB3fssHrnvtr5rhmNxvOb1gqWwsjWY0obMsSFwVuc6jqqsQ5pzVERS1rUuPk9WGONja9bEWq2HNzYHr4x-qObdwlQwjWVV4VyeHN7ODdxShDZL0OQpp0DtKNU-KpZoqKAib01T_o_eXN1IanCrRVLgUWkylblXUOaVHjKfHlPVR6WtnrdHGk0mn_QPD2QJCYKH_HDR9DYKffvv4_e_7zkH29x3bp6sUuODPe3KdDMN-BwrsQvFR3XUaQTZN12w02TRabJyvJXuyf0J3odpTIXy9_Idw</recordid><startdate>20240516</startdate><enddate>20240516</enddate><creator>Sabik, Agnieszka</creator><creator>Daszkiewicz, Karol</creator><creator>Witkowski, Wojciech</creator><creator>Łuczkiewicz, Piotr</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5539-085X</orcidid><orcidid>https://orcid.org/0000-0003-2832-7892</orcidid><orcidid>https://orcid.org/0000-0002-8732-8695</orcidid></search><sort><creationdate>20240516</creationdate><title>Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis</title><author>Sabik, Agnieszka ; Daszkiewicz, Karol ; Witkowski, Wojciech ; Łuczkiewicz, Piotr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c642t-a12a46a1ed70f5131534bcc168d371c566db94f2bb46ec6844b83cf7f13ee3f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Antiarthritic agents</topic><topic>Arthrodesis</topic><topic>Arthrodesis - methods</topic><topic>Bending</topic><topic>Biology and Life Sciences</topic><topic>Biomechanical Phenomena</topic><topic>Biomechanics</topic><topic>Bone growth</topic><topic>Bone Plates</topic><topic>Bones</topic><topic>Bony Callus</topic><topic>Callus</topic><topic>Cartilage</topic><topic>Comparative analysis</topic><topic>Diffusion rate</topic><topic>Finite Element Analysis</topic><topic>Finite element method</topic><topic>Fracture Healing</topic><topic>Fractures</topic><topic>Humans</topic><topic>Joints (anatomy)</topic><topic>Locking</topic><topic>Mathematical models</topic><topic>Mechanical properties</topic><topic>Medical treatment</topic><topic>Medicine and Health Sciences</topic><topic>Mesenchymal stem cells</topic><topic>Metatarsophalangeal Joint - surgery</topic><topic>Osteogenesis</topic><topic>Phenotypes</topic><topic>Physical Sciences</topic><topic>Porous materials</topic><topic>Shear strain</topic><topic>Software</topic><topic>Stem cells</topic><topic>Stiffening</topic><topic>Stiffness</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabik, Agnieszka</creatorcontrib><creatorcontrib>Daszkiewicz, Karol</creatorcontrib><creatorcontrib>Witkowski, Wojciech</creatorcontrib><creatorcontrib>Łuczkiewicz, Piotr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabik, Agnieszka</au><au>Daszkiewicz, Karol</au><au>Witkowski, Wojciech</au><au>Łuczkiewicz, Piotr</au><au>Mehboob, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-05-16</date><risdate>2024</risdate><volume>19</volume><issue>5</issue><spage>e0303752</spage><epage>e0303752</epage><pages>e0303752-e0303752</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>First metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors' previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus for both placements of the locking plate. Two finite element models of the first metatarsophalangeal joint with the dorsally and medially positioned plate were defined in the Abaqus software to simulate differentiation of the fracture callus. A simplified load application, i.e. one single step per each day and the diffusion of the mesenchymal stem cells into the fracture region were assumed in an iterative hardening process. The changes of the mesenchymal stem cells into different phenotypes during the callus stiffening were governed by the octahedral shear strain and interstitial fluid velocity according to Prendergast mechanoregulation theory. Basing on the obtained results the progress of the cartilage and bone tissues formation and their distribution within the callus were compared between two models. The obtained results suggest that after 6 weeks of simulation the healing progress is in general comparable for both plates. However, earlier closing of external callus was observed for the medially positioned plate which had greater vertical bending stiffness. This process enables faster internal callus hardening and promotes symmetrical bridging.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38753866</pmid><doi>10.1371/journal.pone.0303752</doi><tpages>e0303752</tpages><orcidid>https://orcid.org/0000-0001-5539-085X</orcidid><orcidid>https://orcid.org/0000-0003-2832-7892</orcidid><orcidid>https://orcid.org/0000-0002-8732-8695</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2024-05, Vol.19 (5), p.e0303752-e0303752
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_3069288211
source MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry
subjects Analysis
Antiarthritic agents
Arthrodesis
Arthrodesis - methods
Bending
Biology and Life Sciences
Biomechanical Phenomena
Biomechanics
Bone growth
Bone Plates
Bones
Bony Callus
Callus
Cartilage
Comparative analysis
Diffusion rate
Finite Element Analysis
Finite element method
Fracture Healing
Fractures
Humans
Joints (anatomy)
Locking
Mathematical models
Mechanical properties
Medical treatment
Medicine and Health Sciences
Mesenchymal stem cells
Metatarsophalangeal Joint - surgery
Osteogenesis
Phenotypes
Physical Sciences
Porous materials
Shear strain
Software
Stem cells
Stiffening
Stiffness
Velocity
title Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T17%3A01%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20analysis%20of%20mechanical%20conditions%20in%20bone%20union%20following%20first%20metatarsophalangeal%20joint%20arthrodesis%20with%20varied%20locking%20plate%20positions:%20A%20finite%20element%20analysis&rft.jtitle=PloS%20one&rft.au=Sabik,%20Agnieszka&rft.date=2024-05-16&rft.volume=19&rft.issue=5&rft.spage=e0303752&rft.epage=e0303752&rft.pages=e0303752-e0303752&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0303752&rft_dat=%3Cgale_plos_%3EA794065922%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3069288211&rft_id=info:pmid/38753866&rft_galeid=A794065922&rft_doaj_id=oai_doaj_org_article_9160d772552d40f98724a690159e9392&rfr_iscdi=true