Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis
First metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors' previous studies, medially posi...
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description | First metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors' previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus for both placements of the locking plate.
Two finite element models of the first metatarsophalangeal joint with the dorsally and medially positioned plate were defined in the Abaqus software to simulate differentiation of the fracture callus. A simplified load application, i.e. one single step per each day and the diffusion of the mesenchymal stem cells into the fracture region were assumed in an iterative hardening process. The changes of the mesenchymal stem cells into different phenotypes during the callus stiffening were governed by the octahedral shear strain and interstitial fluid velocity according to Prendergast mechanoregulation theory. Basing on the obtained results the progress of the cartilage and bone tissues formation and their distribution within the callus were compared between two models.
The obtained results suggest that after 6 weeks of simulation the healing progress is in general comparable for both plates. However, earlier closing of external callus was observed for the medially positioned plate which had greater vertical bending stiffness. This process enables faster internal callus hardening and promotes symmetrical bridging. |
doi_str_mv | 10.1371/journal.pone.0303752 |
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Two finite element models of the first metatarsophalangeal joint with the dorsally and medially positioned plate were defined in the Abaqus software to simulate differentiation of the fracture callus. A simplified load application, i.e. one single step per each day and the diffusion of the mesenchymal stem cells into the fracture region were assumed in an iterative hardening process. The changes of the mesenchymal stem cells into different phenotypes during the callus stiffening were governed by the octahedral shear strain and interstitial fluid velocity according to Prendergast mechanoregulation theory. Basing on the obtained results the progress of the cartilage and bone tissues formation and their distribution within the callus were compared between two models.
The obtained results suggest that after 6 weeks of simulation the healing progress is in general comparable for both plates. However, earlier closing of external callus was observed for the medially positioned plate which had greater vertical bending stiffness. This process enables faster internal callus hardening and promotes symmetrical bridging.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0303752</identifier><identifier>PMID: 38753866</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Antiarthritic agents ; Arthrodesis ; Arthrodesis - methods ; Bending ; Biology and Life Sciences ; Biomechanical Phenomena ; Biomechanics ; Bone growth ; Bone Plates ; Bones ; Bony Callus ; Callus ; Cartilage ; Comparative analysis ; Diffusion rate ; Finite Element Analysis ; Finite element method ; Fracture Healing ; Fractures ; Humans ; Joints (anatomy) ; Locking ; Mathematical models ; Mechanical properties ; Medical treatment ; Medicine and Health Sciences ; Mesenchymal stem cells ; Metatarsophalangeal Joint - surgery ; Osteogenesis ; Phenotypes ; Physical Sciences ; Porous materials ; Shear strain ; Software ; Stem cells ; Stiffening ; Stiffness ; Velocity</subject><ispartof>PloS one, 2024-05, Vol.19 (5), p.e0303752-e0303752</ispartof><rights>Copyright: © 2024 Sabik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Sabik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Sabik et al 2024 Sabik et al</rights><rights>2024 Sabik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c642t-a12a46a1ed70f5131534bcc168d371c566db94f2bb46ec6844b83cf7f13ee3f83</cites><orcidid>0000-0001-5539-085X ; 0000-0003-2832-7892 ; 0000-0002-8732-8695</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098485/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098485/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38753866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mehboob, Ali</contributor><creatorcontrib>Sabik, Agnieszka</creatorcontrib><creatorcontrib>Daszkiewicz, Karol</creatorcontrib><creatorcontrib>Witkowski, Wojciech</creatorcontrib><creatorcontrib>Łuczkiewicz, Piotr</creatorcontrib><title>Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>First metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors' previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus for both placements of the locking plate.
Two finite element models of the first metatarsophalangeal joint with the dorsally and medially positioned plate were defined in the Abaqus software to simulate differentiation of the fracture callus. A simplified load application, i.e. one single step per each day and the diffusion of the mesenchymal stem cells into the fracture region were assumed in an iterative hardening process. The changes of the mesenchymal stem cells into different phenotypes during the callus stiffening were governed by the octahedral shear strain and interstitial fluid velocity according to Prendergast mechanoregulation theory. Basing on the obtained results the progress of the cartilage and bone tissues formation and their distribution within the callus were compared between two models.
The obtained results suggest that after 6 weeks of simulation the healing progress is in general comparable for both plates. However, earlier closing of external callus was observed for the medially positioned plate which had greater vertical bending stiffness. This process enables faster internal callus hardening and promotes symmetrical bridging.</description><subject>Analysis</subject><subject>Antiarthritic agents</subject><subject>Arthrodesis</subject><subject>Arthrodesis - methods</subject><subject>Bending</subject><subject>Biology and Life Sciences</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Bone growth</subject><subject>Bone Plates</subject><subject>Bones</subject><subject>Bony Callus</subject><subject>Callus</subject><subject>Cartilage</subject><subject>Comparative analysis</subject><subject>Diffusion rate</subject><subject>Finite Element Analysis</subject><subject>Finite element method</subject><subject>Fracture Healing</subject><subject>Fractures</subject><subject>Humans</subject><subject>Joints (anatomy)</subject><subject>Locking</subject><subject>Mathematical models</subject><subject>Mechanical properties</subject><subject>Medical treatment</subject><subject>Medicine and Health Sciences</subject><subject>Mesenchymal stem cells</subject><subject>Metatarsophalangeal Joint - 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The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors' previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus for both placements of the locking plate.
Two finite element models of the first metatarsophalangeal joint with the dorsally and medially positioned plate were defined in the Abaqus software to simulate differentiation of the fracture callus. A simplified load application, i.e. one single step per each day and the diffusion of the mesenchymal stem cells into the fracture region were assumed in an iterative hardening process. The changes of the mesenchymal stem cells into different phenotypes during the callus stiffening were governed by the octahedral shear strain and interstitial fluid velocity according to Prendergast mechanoregulation theory. Basing on the obtained results the progress of the cartilage and bone tissues formation and their distribution within the callus were compared between two models.
The obtained results suggest that after 6 weeks of simulation the healing progress is in general comparable for both plates. However, earlier closing of external callus was observed for the medially positioned plate which had greater vertical bending stiffness. This process enables faster internal callus hardening and promotes symmetrical bridging.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38753866</pmid><doi>10.1371/journal.pone.0303752</doi><tpages>e0303752</tpages><orcidid>https://orcid.org/0000-0001-5539-085X</orcidid><orcidid>https://orcid.org/0000-0003-2832-7892</orcidid><orcidid>https://orcid.org/0000-0002-8732-8695</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Analysis Antiarthritic agents Arthrodesis Arthrodesis - methods Bending Biology and Life Sciences Biomechanical Phenomena Biomechanics Bone growth Bone Plates Bones Bony Callus Callus Cartilage Comparative analysis Diffusion rate Finite Element Analysis Finite element method Fracture Healing Fractures Humans Joints (anatomy) Locking Mathematical models Mechanical properties Medical treatment Medicine and Health Sciences Mesenchymal stem cells Metatarsophalangeal Joint - surgery Osteogenesis Phenotypes Physical Sciences Porous materials Shear strain Software Stem cells Stiffening Stiffness Velocity |
title | Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T17%3A01%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20analysis%20of%20mechanical%20conditions%20in%20bone%20union%20following%20first%20metatarsophalangeal%20joint%20arthrodesis%20with%20varied%20locking%20plate%20positions:%20A%20finite%20element%20analysis&rft.jtitle=PloS%20one&rft.au=Sabik,%20Agnieszka&rft.date=2024-05-16&rft.volume=19&rft.issue=5&rft.spage=e0303752&rft.epage=e0303752&rft.pages=e0303752-e0303752&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0303752&rft_dat=%3Cgale_plos_%3EA794065922%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3069288211&rft_id=info:pmid/38753866&rft_galeid=A794065922&rft_doaj_id=oai_doaj_org_article_9160d772552d40f98724a690159e9392&rfr_iscdi=true |