PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer

Mechanisms underlying primary and acquired resistance to MET tyrosine kinase inhibitors (TKIs) in managing non-small cell lung cancer remain unclear. In this study, we investigated the possible mechanisms acquired for crizotinib in MET-amplified lung carcinoma cell lines. Two MET-amplified lung canc...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0300644
Hauptverfasser:	Thu, Yin Min, Suzawa, Ken, Tomida, Shuta, Ochi, Kosuke, Tsudaka, Shimpei, Takatsu, Fumiaki, Date, Keiichi, Matsuda, Naoki, Iwata, Kazuma, Nakata, Kentaro, Shien, Kazuhiko, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, Toyooka, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Antibodies Antimitotic agents Antineoplastic agents Biology and life sciences c-Met protein Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Crizotinib - pharmacology Crizotinib - therapeutic use Drug dosages Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Epithelial-Mesenchymal Transition - drug effects Gene Expression Regulation, Neoplastic - drug effects Genes Health aspects Humans Kinases Ligands Lung cancer Lung cancer, Small cell Lung carcinoma Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology MAP kinase Medical prognosis Medicine and Health Sciences MEK inhibitors Mitogens Non-small cell lung carcinoma Phosphorylation Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism Plasminogen activator inhibitors Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proteins Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Research and analysis methods Signal transduction Small cell lung carcinoma Targeted cancer therapy Transcriptomics Tumor cell lines Tyrosine Tyrosine kinase inhibitors
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