PPARgamma dependent PEX11beta counteracts the suppressive role of SIRT1 on neural differentiation of HESCs

The membrane peroxisomal proteins PEX11, play a crucial role in peroxisome proliferation by regulating elongation, membrane constriction, and fission of pre-existing peroxisomes. In this study, we evaluated the function of PEX11B gene in neural differentiation of human embryonic stem cell (hESC) by...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0298274
Hauptverfasser:	Esmaeili, Maryam, Nasr-Esfahani, Mohammad Hossein, Shoaraye Nejati, Alireza, Safaeinejad, Zahra, Atefi, Atefeh, L Megraw, Timothy, Ghaedi, Kamran
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Biosynthesis Cell culture Cell differentiation Cell Differentiation - drug effects Cell Line Dehydrogenases Differentiation Embryo cells Embryonic stem cells Enzymes Experiments Gene expression Genes Genetic engineering Genomes Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - drug effects Human Embryonic Stem Cells - metabolism Humans Medicine and Health Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Metabolism Neural tube Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Neurophysiology Neuroprotection Oxidative stress Peroxisome proliferator-activated receptors Peroxisomes - metabolism PPAR gamma - genetics PPAR gamma - metabolism Proteins Research and analysis methods SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Software Stem cells Variance analysis
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