Echinatin attenuates acute lung injury and inflammatory responses via TAK1-MAPK/NF-κB and Keap1-Nrf2-HO-1 signaling pathways in macrophages

Echinatin is an active ingredient in licorice, a traditional Chinese medicine used in the treatment of inflammatory disorders. However, the protective effect and underlying mechanism of echinatin against acute lung injury (ALI) is still unclear. Herein, we aimed to explore echinatin-mediated anti-in...

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Veröffentlicht in:	PloS one 2024-05, Vol.19 (5), p.e0303556-e0303556
Hauptverfasser:	Luo, Liuling, Wang, Huan, Xiong, Jinrui, Chen, Xiaorui, Shen, Xiaofei, Zhang, Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - drug therapy Acute Lung Injury - metabolism Acute Lung Injury - pathology Alveoli Animals Anti-Inflammatory Agents - pharmacology Antibodies Biology and Life Sciences Cell culture Cyclooxygenase-2 Cytokines Gene expression Growth factors Heme oxygenase (decyclizing) Heme Oxygenase-1 - metabolism Herbal medicine IL-1β Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inflammatory diseases Injuries Interleukin 6 Kelch-Like ECH-Associated Protein 1 - metabolism Kinases Lipopolysaccharides Lungs Macrophages Macrophages - drug effects Macrophages - metabolism Male MAP kinase MAP Kinase Kinase Kinases - metabolism Medicine and Health Sciences Membrane Proteins - metabolism Mice Molecular modelling NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric-oxide synthase Oxidative stress Physical Sciences Prostaglandin E2 Proteins RAW 264.7 Cells Reagents Signal Transduction - drug effects TAK1 protein Traditional Chinese medicine Western blotting
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