p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells

Colorectal cancer (CRC) cells harboring KRAS or BRAF mutations show a more-malignant phenotype than cells with wild-type KRAS and BRAF. KRAS/BRAF-wild-type CRCs are sensitive to epidermal growth factor receptor (EGFR)-targeting agents, whereas KRAS/BRAF-mutant CRCs are resistant due to constitutive...

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Veröffentlicht in:	PloS one 2023-11, Vol.18 (11), p.e0294491-e0294491
Hauptverfasser:	Tamura, Shuta, Tazawa, Hiroshi, Hori, Naoto, Li, Yuncheng, Yamada, Motohiko, Kikuchi, Satoru, Kuroda, Shinji, Urata, Yasuo, Kagawa, Shunsuke, Fujiwara, Toshiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses AKT protein Analysis Antibodies Antitumor activity Apoptosis Autophagy Autophagy (Cytology) Cancer Cancer cells Cancer therapies Care and treatment Colorectal cancer Colorectal carcinoma Diagnosis Diagnostic reagents industry Epidermal growth factor Epidermal growth factor receptors Gene mutations Genes Genetic aspects Growth factors Health aspects Immunotherapy Infections K-Ras protein Mutants Mutation Oncolysis p53 Protein Pancreatic cancer Panitumumab Phenotypes Signal transduction Telomerase TOR protein Tumor proteins Viruses Western blotting
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