Metabolomics analysis of pathways underlying radiation-induced salivary gland dysfunction stages

Salivary gland hypofunction is an adverse side effect associated with radiotherapy for head and neck cancer patients. This study delineated metabolic changes at acute, intermediate, and chronic radiation damage response stages in mouse salivary glands following a single 5 Gy dose. Ultra-high perform...

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Veröffentlicht in:	PloS one 2023-11, Vol.18 (11), p.e0294355-e0294355
Hauptverfasser:	Buss, Lauren G, De Oliveira Pessoa, Diogo, Snider, Justin M, Padi, Megha, Martinez, Jessica A, Limesand, Kirsten H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Animals Annotations Cancer Cancer therapies Carbon Carbon - metabolism Care and treatment Chromatography Complications and side effects Diagnosis Enrichment Evaluation Exocrine glands Glutathione Glutathione - metabolism Head & neck cancer Head and neck cancer Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - radiotherapy High performance liquid chromatography Humans Liquid chromatography Mass spectrometry Mass spectroscopy Medical research Medicine, Experimental Metabolism Metabolites Metabolomics Mice Network analysis Nuclear energy Parotid Gland - radiation effects Patient outcomes Physiological aspects Radiation Radiation damage Radiation effects Radiation therapy Radiotherapy Salivary gland Salivary glands Salivary Glands - metabolism Scientific imaging Solvents Tumors Xerostomia - metabolism
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