Testing biological actions of medicinal plants from northern Vietnam on zebrafish embryos and larvae: Developmental, behavioral, and putative therapeutical effects
Evaluating the risks and benefits of using traditional medicinal plants is of utmost importance for a huge fraction of the human population, in particular in Northern Vietnam. Zebrafish are increasingly used as a simple vertebrate model for testing toxic and physiological effects of compounds, espec...
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| Veröffentlicht in: | PloS one 2023-11, Vol.18 (11), p.e0294048-e0294048 |
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| creator | Tran, My Hanh Nguyen, Thi Van Anh Do, Hoang Giang Kieu, Trung Kien Nguyen, Thi Kim Thanh Le, Hong Diep Guerrero-Limon, Gustavo Massoz, Laura Nivelle, Renaud Zappia, Jérémie Pham, Hai The Nguyen, Lai Thanh Muller, Marc |
| description | Evaluating the risks and benefits of using traditional medicinal plants is of utmost importance for a huge fraction of the human population, in particular in Northern Vietnam. Zebrafish are increasingly used as a simple vertebrate model for testing toxic and physiological effects of compounds, especially on development. Here, we tested 12 ethanolic extracts from popular medicinal plants collected in northern Vietnam for their effects on zebrafish survival and development during the first 4 days after fertilization. We characterized more in detail their effects on epiboly, hatching, growth, necrosis, body curvature, angiogenesis, skeletal development and mostly increased movement behavior. Finally, we confirm the effect on epiboly caused by the Mahonia bealei extract by staining the actin filaments and performing whole genome gene expression analysis. Further, we show that this extract also inhibits cell migration of mouse embryo fibroblasts. Finally, we analyzed the chemical composition of the Mahonia bealei extract and test the effects of its major components. In conclusion, we show that traditional medicinal plant extracts are able to affect zebrafish early life stage development to various degrees. In addition, we show that an extract causing delay in epiboly also inhibits mammalian cell migration, suggesting that this effect may serve as a preliminary test for identifying extracts that inhibit cancer metastasis. |
| doi_str_mv | 10.1371/journal.pone.0294048 |
| format | Article |
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Zebrafish are increasingly used as a simple vertebrate model for testing toxic and physiological effects of compounds, especially on development. Here, we tested 12 ethanolic extracts from popular medicinal plants collected in northern Vietnam for their effects on zebrafish survival and development during the first 4 days after fertilization. We characterized more in detail their effects on epiboly, hatching, growth, necrosis, body curvature, angiogenesis, skeletal development and mostly increased movement behavior. Finally, we confirm the effect on epiboly caused by the Mahonia bealei extract by staining the actin filaments and performing whole genome gene expression analysis. Further, we show that this extract also inhibits cell migration of mouse embryo fibroblasts. Finally, we analyzed the chemical composition of the Mahonia bealei extract and test the effects of its major components. In conclusion, we show that traditional medicinal plant extracts are able to affect zebrafish early life stage development to various degrees. In addition, we show that an extract causing delay in epiboly also inhibits mammalian cell migration, suggesting that this effect may serve as a preliminary test for identifying extracts that inhibit cancer metastasis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0294048</identifier><identifier>PMID: 37934745</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Actin ; Analysis ; Angiogenesis ; Animals ; Biological diversity ; Biological products ; Biology ; Biology and Life Sciences ; Cell migration ; Cells ; Chemical composition ; Danio rerio ; Developmental stages ; Embryo fibroblasts ; Embryo, Nonmammalian ; Embryonic development ; Embryos ; Fertilization ; Filaments ; Gene expression ; Genomic analysis ; Genomics ; Hatching ; Health aspects ; Herbal medicine ; Human health sciences ; Human populations ; Humans ; Larva ; Larvae ; Life sciences ; Mahonia bealei ; Mammals ; Medicinal plants ; Medicine and Health Sciences ; Medicine, Botanic ; Medicine, Herbal ; Metastases ; Methylene blue ; Mice ; Morphology ; Multidisciplinary ; Muscle proteins ; Médecine vétérinaire & santé animale ; Necrosis ; Pharmacie, pharmacologie & toxicologie ; Pharmacy, pharmacology & toxicology ; Physiological effects ; Phytochemicals ; Plant Extracts ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plants, Medicinal ; Properties ; Research and Analysis Methods ; Sciences de la santé humaine ; Sciences du vivant ; Toxicity ; Toxicity testing ; Vertebrates ; Veterinary medicine & animal health ; Vietnam ; Zebra fish ; Zebrafish ; Zebrafish/genetics</subject><ispartof>PloS one, 2023-11, Vol.18 (11), p.e0294048-e0294048</ispartof><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Tran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Tran et al 2023 Tran et al</rights><rights>2023 Tran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Zebrafish are increasingly used as a simple vertebrate model for testing toxic and physiological effects of compounds, especially on development. Here, we tested 12 ethanolic extracts from popular medicinal plants collected in northern Vietnam for their effects on zebrafish survival and development during the first 4 days after fertilization. We characterized more in detail their effects on epiboly, hatching, growth, necrosis, body curvature, angiogenesis, skeletal development and mostly increased movement behavior. Finally, we confirm the effect on epiboly caused by the Mahonia bealei extract by staining the actin filaments and performing whole genome gene expression analysis. Further, we show that this extract also inhibits cell migration of mouse embryo fibroblasts. Finally, we analyzed the chemical composition of the Mahonia bealei extract and test the effects of its major components. 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran, My Hanh</au><au>Nguyen, Thi Van Anh</au><au>Do, Hoang Giang</au><au>Kieu, Trung Kien</au><au>Nguyen, Thi Kim Thanh</au><au>Le, Hong Diep</au><au>Guerrero-Limon, Gustavo</au><au>Massoz, Laura</au><au>Nivelle, Renaud</au><au>Zappia, Jérémie</au><au>Pham, Hai The</au><au>Nguyen, Lai Thanh</au><au>Muller, Marc</au><au>Klymkowsky, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testing biological actions of medicinal plants from northern Vietnam on zebrafish embryos and larvae: Developmental, behavioral, and putative therapeutical effects</atitle><jtitle>PloS one</jtitle><date>2023-11-07</date><risdate>2023</risdate><volume>18</volume><issue>11</issue><spage>e0294048</spage><epage>e0294048</epage><pages>e0294048-e0294048</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Evaluating the risks and benefits of using traditional medicinal plants is of utmost importance for a huge fraction of the human population, in particular in Northern Vietnam. Zebrafish are increasingly used as a simple vertebrate model for testing toxic and physiological effects of compounds, especially on development. Here, we tested 12 ethanolic extracts from popular medicinal plants collected in northern Vietnam for their effects on zebrafish survival and development during the first 4 days after fertilization. We characterized more in detail their effects on epiboly, hatching, growth, necrosis, body curvature, angiogenesis, skeletal development and mostly increased movement behavior. Finally, we confirm the effect on epiboly caused by the Mahonia bealei extract by staining the actin filaments and performing whole genome gene expression analysis. Further, we show that this extract also inhibits cell migration of mouse embryo fibroblasts. Finally, we analyzed the chemical composition of the Mahonia bealei extract and test the effects of its major components. In conclusion, we show that traditional medicinal plant extracts are able to affect zebrafish early life stage development to various degrees. In addition, we show that an extract causing delay in epiboly also inhibits mammalian cell migration, suggesting that this effect may serve as a preliminary test for identifying extracts that inhibit cancer metastasis.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>37934745</pmid><doi>10.1371/journal.pone.0294048</doi><tpages>e0294048</tpages><orcidid>https://orcid.org/0000-0001-9227-6992</orcidid><orcidid>https://orcid.org/0000-0001-6030-2164</orcidid><orcidid>https://orcid.org/0000-0001-6431-0698</orcidid><orcidid>https://orcid.org/0000-0002-2723-7564</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-11, Vol.18 (11), p.e0294048-e0294048 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_3069280491 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Actin Analysis Angiogenesis Animals Biological diversity Biological products Biology Biology and Life Sciences Cell migration Cells Chemical composition Danio rerio Developmental stages Embryo fibroblasts Embryo, Nonmammalian Embryonic development Embryos Fertilization Filaments Gene expression Genomic analysis Genomics Hatching Health aspects Herbal medicine Human health sciences Human populations Humans Larva Larvae Life sciences Mahonia bealei Mammals Medicinal plants Medicine and Health Sciences Medicine, Botanic Medicine, Herbal Metastases Methylene blue Mice Morphology Multidisciplinary Muscle proteins Médecine vétérinaire & santé animale Necrosis Pharmacie, pharmacologie & toxicologie Pharmacy, pharmacology & toxicology Physiological effects Phytochemicals Plant Extracts Plant Extracts/chemistry Plant Extracts/pharmacology Plants, Medicinal Properties Research and Analysis Methods Sciences de la santé humaine Sciences du vivant Toxicity Toxicity testing Vertebrates Veterinary medicine & animal health Vietnam Zebra fish Zebrafish Zebrafish/genetics |
| title | Testing biological actions of medicinal plants from northern Vietnam on zebrafish embryos and larvae: Developmental, behavioral, and putative therapeutical effects |
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