Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation

Because pigs are intermediate or amplifying hosts for several zoonotic viruses, the pig-derived PK-15 cell line is an indispensable tool for studying viral pathogenicity and developing treatments, vaccines, and preventive measures to mitigate the risk of disease outbreaks. However, we must consider...

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Veröffentlicht in:	PloS one 2023-11, Vol.18 (11), p.e0289863-e0289863
Hauptverfasser:	Shofa, Maya, Saito, Akatsuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Contamination CRISPR Diagnosis Double-stranded RNA Genes Genetic transcription Genetic vectors Health aspects Health risks Hogs Influenza viruses Interferon Lipopolysaccharides Pathogenicity Pathogens Plasmids Polyinosinic:polycytidylic acid Risk assessment RNA RNA viruses Stat2 protein Swine Vaccines Viral infections Virus diseases Viruses α-Interferon β-Interferon
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