In silico exploration of Serratia sp. BRL41 genome for detecting prodigiosin Biosynthetic Gene Cluster (BGC) and in vitro antimicrobial activity assessment of secreted prodigiosin

The raising concern of drug resistance, having substantial impacts on public health, has instigated the search of new natural compounds with substantial medicinal activity. In order to find out a natural solution, the current study has utilized prodigiosin, a linear tripyrrole red pigment, as an act...

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Veröffentlicht in:	PloS one 2023-11, Vol.18 (11), p.e0294054-e0294054
Hauptverfasser:	Boby, Farhana, Bhuiyan, Md. Nurul Huda, Saha, Barun Kanti, Dey, Subarna Sandhani, Saha, Anik Kumar, Islam, Md Jahidul, Bashera, Mahci Al, Moulick, Shyama Prosad, Jahan, Farhana, Zaman, Md. Asad Uz, Chowdhury, Sanjana Fatema, Naser, Showti Raheel, Khan, Md. Salim, Sarkar, Md. Murshed Hasan
Format:	Artikel
Sprache:	eng
Schlagworte:	Active control Amides Analysis Antibacterial activity Antibiotics Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Bacteria Bacterial infections Beta lactamases Biochemical characteristics Biochemistry Biofilms Biosynthesis Care and treatment Cell cycle Cell membranes Chromatography Cluster analysis Cytotoxicity Deoxyribonucleic acid Destabilization DNA DNA sequencing Drug resistance Drug resistance in microorganisms E coli Escherichia coli Ethylenediaminetetraacetic acid Fourier transforms Free radicals Gene clusters Gene sequencing Genes Genetic engineering Genomes Genomics Glutathione Glycerol Gram-negative bacteria Gram-positive bacteria Growth media Infrared spectroscopy Laboratories Methicillin Minimum inhibitory concentration Nucleotide sequencing Oxidation Patient outcomes Phylogenetics Physical characteristics Physiological aspects Prodigiosin Public health Reactive oxygen species Red pigments Scavenging Serratia Similarity Spectrophotometry Spectrum analysis Staphylococcus infections Thin layer chromatography Virulence Virulence (Microbiology) Whole genome sequencing β-Lactam antibiotics
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