The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study
This study aimed to determine the contribution of titanium prepared platelet-rich fibrin (T-PRF) with open flap debridement (OFD) on clinical, biochemical and radiographic measurements of periodontal regeneration. Twenty periodontitis patients with bilateral intrabony defects and stage III grade A p...
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| Veröffentlicht in: | PloS one 2024-06, Vol.19 (6), p.e0304970 |
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| description | This study aimed to determine the contribution of titanium prepared platelet-rich fibrin (T-PRF) with open flap debridement (OFD) on clinical, biochemical and radiographic measurements of periodontal regeneration. Twenty periodontitis patients with bilateral intrabony defects and stage III grade A periodontitis were included in the study. A total of 40 defects were randomly selected for OFD alone (control group, n = 20) or combined OFD+ T-PRF (test group, n = 20). Clinical and radiographic parameters (at baseline and nine months after surgery), and growth factor levels in gingival crevicular fluid (at baseline and at two, four, six, and twelve weeks after surgical treatment) were also evaluated. Considering the clinical parameters, alterations in probing pocket depth, gingival marginal level and clinical endpoint in the test regions treated with T-PRF significantly improved (P |
| doi_str_mv | 10.1371/journal.pone.0304970 |
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Twenty periodontitis patients with bilateral intrabony defects and stage III grade A periodontitis were included in the study. A total of 40 defects were randomly selected for OFD alone (control group, n = 20) or combined OFD+ T-PRF (test group, n = 20). Clinical and radiographic parameters (at baseline and nine months after surgery), and growth factor levels in gingival crevicular fluid (at baseline and at two, four, six, and twelve weeks after surgical treatment) were also evaluated. Considering the clinical parameters, alterations in probing pocket depth, gingival marginal level and clinical endpoint in the test regions treated with T-PRF significantly improved (P<0.05). Fibroblast growth factor-2 and platelet-derived growth factor-BB levels between the two groups in the second and fourth weeks were also significantly different (P<0.05). Furthermore, the receptor activator of nuclear factor κB ligand/osteoprotegerin ratio between the groups was significantly different in the second, fourth, sixth, and twelfth weeks (P<0.05). The bone-filling rate was also significantly greater in the test group than in the control group (P <0.001). Compared with OFD alone, combining T-PRF with the procedure was more successful with regards to clinical, radiographic, and biochemical measurements of periodontal regeneration.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0304970</identifier><identifier>PMID: 38843242</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alveolar Bone Loss - diagnostic imaging ; Alveolar Bone Loss - surgery ; Biology and Life Sciences ; Clinical trials ; Defects ; Female ; Fibrin ; Fibroblast growth factor 2 ; Fibroblast growth factors ; Gingival Crevicular Fluid - metabolism ; Growth factors ; Gum disease ; Humans ; Male ; Medicine and Health Sciences ; Middle Aged ; Oral hygiene ; Osteoprotegerin ; Parameters ; Patients ; Periodontics ; Periodontitis ; Periodontitis - surgery ; Platelet-derived growth factor ; Platelet-Rich Fibrin - metabolism ; Regeneration ; Research and Analysis Methods ; Surgical implants ; Teeth ; Titanium</subject><ispartof>PloS one, 2024-06, Vol.19 (6), p.e0304970</ispartof><rights>Copyright: © 2024 Ozkal Eminoglu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Ozkal Eminoglu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Ozkal Eminoglu et al 2024 Ozkal Eminoglu et al</rights><rights>2024 Ozkal Eminoglu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Twenty periodontitis patients with bilateral intrabony defects and stage III grade A periodontitis were included in the study. A total of 40 defects were randomly selected for OFD alone (control group, n = 20) or combined OFD+ T-PRF (test group, n = 20). Clinical and radiographic parameters (at baseline and nine months after surgery), and growth factor levels in gingival crevicular fluid (at baseline and at two, four, six, and twelve weeks after surgical treatment) were also evaluated. Considering the clinical parameters, alterations in probing pocket depth, gingival marginal level and clinical endpoint in the test regions treated with T-PRF significantly improved (P<0.05). Fibroblast growth factor-2 and platelet-derived growth factor-BB levels between the two groups in the second and fourth weeks were also significantly different (P<0.05). Furthermore, the receptor activator of nuclear factor κB ligand/osteoprotegerin ratio between the groups was significantly different in the second, fourth, sixth, and twelfth weeks (P<0.05). The bone-filling rate was also significantly greater in the test group than in the control group (P <0.001). Compared with OFD alone, combining T-PRF with the procedure was more successful with regards to clinical, radiographic, and biochemical measurements of periodontal regeneration.</description><subject>Adult</subject><subject>Alveolar Bone Loss - diagnostic imaging</subject><subject>Alveolar Bone Loss - surgery</subject><subject>Biology and Life Sciences</subject><subject>Clinical trials</subject><subject>Defects</subject><subject>Female</subject><subject>Fibrin</subject><subject>Fibroblast growth factor 2</subject><subject>Fibroblast growth factors</subject><subject>Gingival Crevicular Fluid - metabolism</subject><subject>Growth factors</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Oral hygiene</subject><subject>Osteoprotegerin</subject><subject>Parameters</subject><subject>Patients</subject><subject>Periodontics</subject><subject>Periodontitis</subject><subject>Periodontitis - surgery</subject><subject>Platelet-derived growth factor</subject><subject>Platelet-Rich Fibrin - metabolism</subject><subject>Regeneration</subject><subject>Research and Analysis Methods</subject><subject>Surgical implants</subject><subject>Teeth</subject><subject>Titanium</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwDxBYQqrgkMWOEyfmglYVH5UqVYLC1XKcycaVY6e2g7qc-Ol4IaBd1APywSP7mXc87zjLnhK8IrQmr6_d7K00q8lZWGGKS17je9kx4bTIWYHp_b34KHsUwjXGFW0Ye5gd0aYpaVEWx9mPqwEQ9D2oiFyPoo7S6nnMJyMjGIjIazWgXrdeW-QsmsBr1zkbpUHaRi9bZ7eog51AeIPWyEvbuVF_hw6phHlnTArDZHTMRzfHASmjrVYpP8S52z7OHvTSBHiy7CfZl_fvrs4-5heXH87P1hf5pmQk5iXlfY0ZLVRVYZnaaFVZqJZWLW6Ljpd1WRYNdBiaRkoGpOlYRRRvFafQsFrRk-z5b93JuCAW84KgmPGixpjyRLxdiLkdoVOwa8-IyetR-q1wUovDG6sHsXHfBCGkYgWvksLLRcG7mxlCFKMOCoyRFtz8q1jF67rBNKEv_kHvftJCbaQBoW3vUmG1ExXrmrPUYsNxolZ3UGl1MOo0BOh1Oj9IeHWQsBsU3MaNnEMQ558__T97-fWQPd1jB5AmDsGZOWpnwyH4bN_qvx7_-Zf0Jwqr5OU</recordid><startdate>20240606</startdate><enddate>20240606</enddate><creator>Ozkal Eminoglu, Didem</creator><creator>Arabaci, Taner</creator><creator>Oztas Sahiner, Gurbet Alev</creator><general>Public Library of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0565-6194</orcidid></search><sort><creationdate>20240606</creationdate><title>The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study</title><author>Ozkal Eminoglu, Didem ; Arabaci, Taner ; Oztas Sahiner, Gurbet Alev</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g461t-439f70632c550a386bc42cb35b0b2d9474428ed0e88aa6e18d651c9bc93e867c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Alveolar Bone Loss - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozkal Eminoglu, Didem</au><au>Arabaci, Taner</au><au>Oztas Sahiner, Gurbet Alev</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-06-06</date><risdate>2024</risdate><volume>19</volume><issue>6</issue><spage>e0304970</spage><pages>e0304970-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to determine the contribution of titanium prepared platelet-rich fibrin (T-PRF) with open flap debridement (OFD) on clinical, biochemical and radiographic measurements of periodontal regeneration. Twenty periodontitis patients with bilateral intrabony defects and stage III grade A periodontitis were included in the study. A total of 40 defects were randomly selected for OFD alone (control group, n = 20) or combined OFD+ T-PRF (test group, n = 20). Clinical and radiographic parameters (at baseline and nine months after surgery), and growth factor levels in gingival crevicular fluid (at baseline and at two, four, six, and twelve weeks after surgical treatment) were also evaluated. Considering the clinical parameters, alterations in probing pocket depth, gingival marginal level and clinical endpoint in the test regions treated with T-PRF significantly improved (P<0.05). Fibroblast growth factor-2 and platelet-derived growth factor-BB levels between the two groups in the second and fourth weeks were also significantly different (P<0.05). Furthermore, the receptor activator of nuclear factor κB ligand/osteoprotegerin ratio between the groups was significantly different in the second, fourth, sixth, and twelfth weeks (P<0.05). The bone-filling rate was also significantly greater in the test group than in the control group (P <0.001). Compared with OFD alone, combining T-PRF with the procedure was more successful with regards to clinical, radiographic, and biochemical measurements of periodontal regeneration.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38843242</pmid><doi>10.1371/journal.pone.0304970</doi><tpages>e0304970</tpages><orcidid>https://orcid.org/0000-0002-0565-6194</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alveolar Bone Loss - diagnostic imaging Alveolar Bone Loss - surgery Biology and Life Sciences Clinical trials Defects Female Fibrin Fibroblast growth factor 2 Fibroblast growth factors Gingival Crevicular Fluid - metabolism Growth factors Gum disease Humans Male Medicine and Health Sciences Middle Aged Oral hygiene Osteoprotegerin Parameters Patients Periodontics Periodontitis Periodontitis - surgery Platelet-derived growth factor Platelet-Rich Fibrin - metabolism Regeneration Research and Analysis Methods Surgical implants Teeth Titanium |
| title | The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study |
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