Gut microbial diversity and functional characterization in people with alcohol use disorder: A case-control study
Individuals with Alcohol Use Disorder (AUD) typically have comorbid chronic health conditions, including anxiety and depression disorders, increased sleep disruption, and poor nutrition status, along with gut microbial dysbiosis. To better understand the effects of gut dysbiosis previously shown in...
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| creator | Piacentino, Daria Vizioli, Carlotta Barb, Jennifer J Grant-Beurmann, Silvia Bouhlal, Sofia Battista, Jillian T Jennings, Olivia Lee, Mary R Schwandt, Melanie L Walter, Peter Henderson, Wendy A Chen, Kun Turner, Sara Yang, Shanna Fraser, Claire M Farinelli, Lisa A Farokhnia, Mehdi Leggio, Lorenzo |
| description | Individuals with Alcohol Use Disorder (AUD) typically have comorbid chronic health conditions, including anxiety and depression disorders, increased sleep disruption, and poor nutrition status, along with gut microbial dysbiosis. To better understand the effects of gut dysbiosis previously shown in individuals with AUD, gut microbiome and metabolome were investigated between three cohorts. Two groups of individuals with AUD included treatment-seeking newly abstinent for at least six weeks (AB: N = 10) and non-treatment-seeking currently drinking (CD: N = 9) individuals. The third group was age, gender, and BMI-matched healthy controls (HC: N = 12). Deep phenotyping during two weeks of outpatient National Institutes of Health Clinical Center visits was performed, including clinical, psychological, medical, metabolic, dietary, and experimental assessments. Alpha and beta diversity and differential microbial taxa and metabolite abundance of the gut microbiome were examined across the three groups. Metabolites derived from the lipid super-pathway were identified to be more abundant in the AB group compared to CD and HC groups. The AB individuals appeared to be most clinically different from CD and HC individuals with respect to their gut microbiome and metabolome. These findings highlight the potential long-term effects of chronic alcohol use in individuals with AUD, even during short-term abstinence. |
| doi_str_mv | 10.1371/journal.pone.0302195 |
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To better understand the effects of gut dysbiosis previously shown in individuals with AUD, gut microbiome and metabolome were investigated between three cohorts. Two groups of individuals with AUD included treatment-seeking newly abstinent for at least six weeks (AB: N = 10) and non-treatment-seeking currently drinking (CD: N = 9) individuals. The third group was age, gender, and BMI-matched healthy controls (HC: N = 12). Deep phenotyping during two weeks of outpatient National Institutes of Health Clinical Center visits was performed, including clinical, psychological, medical, metabolic, dietary, and experimental assessments. Alpha and beta diversity and differential microbial taxa and metabolite abundance of the gut microbiome were examined across the three groups. Metabolites derived from the lipid super-pathway were identified to be more abundant in the AB group compared to CD and HC groups. The AB individuals appeared to be most clinically different from CD and HC individuals with respect to their gut microbiome and metabolome. These findings highlight the potential long-term effects of chronic alcohol use in individuals with AUD, even during short-term abstinence.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0302195</identifier><identifier>PMID: 38865325</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abstinence ; Adult ; Alcohol use ; Alcoholism - metabolism ; Alcoholism - microbiology ; Amino acids ; Anxiety ; Biological diversity ; Biology and Life Sciences ; Case-Control Studies ; Drinking behavior ; Drinking of alcoholic beverages ; Dysbacteriosis ; Dysbiosis - microbiology ; Female ; Gastrointestinal Microbiome ; Health services ; Humans ; Intestinal microflora ; Lipids ; Long-term effects ; Male ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Mental depression ; Mental disorders ; Metabolism ; Metabolites ; Metabolome ; Microbiomes ; Microorganisms ; Middle Aged ; Phenotyping ; Psychopathology ; Social Sciences ; Type 2 diabetes</subject><ispartof>PloS one, 2024-06, Vol.19 (6), p.e0302195</ispartof><rights>Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. 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| recordid | cdi_plos_journals_3069266153 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abstinence Adult Alcohol use Alcoholism - metabolism Alcoholism - microbiology Amino acids Anxiety Biological diversity Biology and Life Sciences Case-Control Studies Drinking behavior Drinking of alcoholic beverages Dysbacteriosis Dysbiosis - microbiology Female Gastrointestinal Microbiome Health services Humans Intestinal microflora Lipids Long-term effects Male Medical research Medicine and Health Sciences Medicine, Experimental Mental depression Mental disorders Metabolism Metabolites Metabolome Microbiomes Microorganisms Middle Aged Phenotyping Psychopathology Social Sciences Type 2 diabetes |
| title | Gut microbial diversity and functional characterization in people with alcohol use disorder: A case-control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T20%3A35%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gut%20microbial%20diversity%20and%20functional%20characterization%20in%20people%20with%20alcohol%20use%20disorder:%20A%20case-control%20study&rft.jtitle=PloS%20one&rft.au=Piacentino,%20Daria&rft.date=2024-06-12&rft.volume=19&rft.issue=6&rft.spage=e0302195&rft.pages=e0302195-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0302195&rft_dat=%3Cgale_plos_%3EA797496381%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3069266153&rft_id=info:pmid/38865325&rft_galeid=A797496381&rfr_iscdi=true |