Postnatal maternal care moderates the effects of prenatal bisphenol exposure on offspring neurodevelopmental, behavioral, and transcriptomic outcomes
Bisphenols (BP), including BPA and "BPA-free" structural analogs, are commonly used plasticizers that are present in many plastics and are known endocrine disrupting chemicals. Prenatal exposure to BPA has been associated with negative neurodevelopmental and behavioral outcomes in children...
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| description | Bisphenols (BP), including BPA and "BPA-free" structural analogs, are commonly used plasticizers that are present in many plastics and are known endocrine disrupting chemicals. Prenatal exposure to BPA has been associated with negative neurodevelopmental and behavioral outcomes in children and in rodent models. Prenatal BPA exposure has also been shown to impair postnatal maternal care provisioning, which can also affect offspring neurodevelopment and behavior. However, there is limited knowledge regarding the biological effects of prenatal exposure to bisphenols other than BPA and the interplay between prenatal bisphenol exposure and postnatal maternal care on adult behavior. The purpose of the current study was to determine the interactive impact of prenatal bisphenol exposure and postnatal maternal care on neurodevelopment and behavior in rats. Our findings suggest that the effects of prenatal bisphenol exposure on eye-opening, adult attentional set shifting and anxiety-like behavior in the open field are dependent on maternal care in the first five days of life. Interestingly, maternal care might also attenuate the effects of prenatal bisphenol exposure on eye opening and adult attentional set shifting. Finally, transcriptomic profiles in male and female medial prefrontal cortex and amygdala suggest that the interactive effects of prenatal bisphenol exposure and postnatal maternal care converge on estrogen receptor signaling and are involved in biological processes related to gene expression and protein translation and synthesis. Overall, these findings indicate that postnatal maternal care plays a critical role in the expression of the effects of prenatal bisphenol exposure on neurodevelopment and adult behavior. Understanding the underlying biological mechanisms involved might allow us to identify potential avenues to mitigate the adverse effects of prenatal bisphenol exposure and improve health and well-being in human populations. |
| doi_str_mv | 10.1371/journal.pone.0305256 |
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Prenatal exposure to BPA has been associated with negative neurodevelopmental and behavioral outcomes in children and in rodent models. Prenatal BPA exposure has also been shown to impair postnatal maternal care provisioning, which can also affect offspring neurodevelopment and behavior. However, there is limited knowledge regarding the biological effects of prenatal exposure to bisphenols other than BPA and the interplay between prenatal bisphenol exposure and postnatal maternal care on adult behavior. The purpose of the current study was to determine the interactive impact of prenatal bisphenol exposure and postnatal maternal care on neurodevelopment and behavior in rats. Our findings suggest that the effects of prenatal bisphenol exposure on eye-opening, adult attentional set shifting and anxiety-like behavior in the open field are dependent on maternal care in the first five days of life. Interestingly, maternal care might also attenuate the effects of prenatal bisphenol exposure on eye opening and adult attentional set shifting. Finally, transcriptomic profiles in male and female medial prefrontal cortex and amygdala suggest that the interactive effects of prenatal bisphenol exposure and postnatal maternal care converge on estrogen receptor signaling and are involved in biological processes related to gene expression and protein translation and synthesis. Overall, these findings indicate that postnatal maternal care plays a critical role in the expression of the effects of prenatal bisphenol exposure on neurodevelopment and adult behavior. Understanding the underlying biological mechanisms involved might allow us to identify potential avenues to mitigate the adverse effects of prenatal bisphenol exposure and improve health and well-being in human populations.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0305256</identifier><identifier>PMID: 38861567</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amygdala ; Analogs ; Analysis ; Animal models ; Animals ; Anxiety ; Attentional bias ; Behavior ; Behavior, Animal - drug effects ; Benzhydryl Compounds - toxicity ; Biological activity ; Biological effects ; Biology and Life Sciences ; Bisphenol A ; Bisphenols ; Brain ; DNA methylation ; Endocrine disruptors ; Endocrine Disruptors - toxicity ; Estrogen ; Estrogen receptors ; Estrogens ; Exposure ; Female ; Females ; Gene expression ; Genes ; Genetic translation ; Human populations ; Laboratory animals ; Male ; Maternal behavior ; Maternal Behavior - drug effects ; Maternal Exposure - adverse effects ; Medicine and Health Sciences ; Neurodevelopment ; Offspring ; Open-field behavior ; Phenols - toxicity ; Phthalates ; Postnatal Care ; Prefrontal cortex ; Pregnancy ; Pregnant women ; Prenatal experience ; Prenatal exposure ; Prenatal Exposure Delayed Effects ; Protein biosynthesis ; Provisioning ; Rats ; Research and Analysis Methods ; Social Sciences ; Transcriptome - drug effects ; Transcriptomics ; Well being</subject><ispartof>PloS one, 2024-06, Vol.19 (6), p.e0305256</ispartof><rights>Copyright: © 2024 Lauby et al. 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This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Understanding the underlying biological mechanisms involved might allow us to identify potential avenues to mitigate the adverse effects of prenatal bisphenol exposure and improve health and well-being in human populations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38861567</pmid><doi>10.1371/journal.pone.0305256</doi><tpages>e0305256</tpages><orcidid>https://orcid.org/0000-0001-5676-1333</orcidid><orcidid>https://orcid.org/0000-0002-3922-084X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2024-06, Vol.19 (6), p.e0305256 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amygdala Analogs Analysis Animal models Animals Anxiety Attentional bias Behavior Behavior, Animal - drug effects Benzhydryl Compounds - toxicity Biological activity Biological effects Biology and Life Sciences Bisphenol A Bisphenols Brain DNA methylation Endocrine disruptors Endocrine Disruptors - toxicity Estrogen Estrogen receptors Estrogens Exposure Female Females Gene expression Genes Genetic translation Human populations Laboratory animals Male Maternal behavior Maternal Behavior - drug effects Maternal Exposure - adverse effects Medicine and Health Sciences Neurodevelopment Offspring Open-field behavior Phenols - toxicity Phthalates Postnatal Care Prefrontal cortex Pregnancy Pregnant women Prenatal experience Prenatal exposure Prenatal Exposure Delayed Effects Protein biosynthesis Provisioning Rats Research and Analysis Methods Social Sciences Transcriptome - drug effects Transcriptomics Well being |
| title | Postnatal maternal care moderates the effects of prenatal bisphenol exposure on offspring neurodevelopmental, behavioral, and transcriptomic outcomes |
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