Difference in TMPRSS2 usage by Delta and Omicron variants of SARS-CoV-2: Implication for a sudden increase among children

It has been postulated from a combination of evidence that a sudden increase in COVID-19 cases among pediatric patients after onset of the Omicron wave was attributed to a reduced requirement for TMPRSS2-mediated entry in pediatric airways with lower expression levels of TMPRSS2. Epidemic strains we...

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Veröffentlicht in:	PloS one 2024-06, Vol.19 (6), p.e0299445
Hauptverfasser:	Kakee, Sosuke, Kanai, Kyosuke, Tsuneki-Tokunaga, Akeno, Okuno, Keisuke, Namba, Noriyuki, Tomita, Katsuyuki, Chikumi, Hiroki, Kageyama, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biology and life sciences Cell culture Child Child, Preschool Children Chlorocebus aethiops Computer and Information Sciences COVID-19 COVID-19 - epidemiology COVID-19 - metabolism COVID-19 - virology Culture Disease transmission Epidemics Ethics Female Health aspects Homology Humans Infant Infections Male Medicine and health sciences Pandemics Patients Pediatrics Phylogenetics Phylogeny Polymerase chain reaction Proteins Research and Analysis Methods Respiratory organs SARS-CoV-2 - genetics SARS-CoV-2 - isolation & purification Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Severe acute respiratory syndrome coronavirus 2 Vero Cells
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