B memory cell responses to LPS, IVP and IpaB antigen after oral vaccination with Shigella sonnei vaccine candidates WRSs2 and WRSs3

B memory (BM) cell responses were evaluated using peripheral blood mononuclear cells that were collected and cryopreserved during a Phase 1 trial of two live Shigella sonnei vaccine candidates WRSs2 and WRSs3. An ELISpot assay was used to measure IgG+ and IgA+ BM cell responses against S. sonnei LPS...

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Veröffentlicht in:	PloS one 2024-01, Vol.19 (1), p.e0290987-e0290987
Hauptverfasser:	Venkatesan, Malabi M, Barnoy, Shoshana, Frenck, Robert, McNeal, Monica, Baqar, Shahida
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibodies Antibodies, Bacterial Antigens B cells Bacterial Proteins Biology and Life Sciences Clinical Trials, Phase I as Topic Complications and side effects Cryopreservation Distribution Enzyme-linked immunosorbent assay FDA approval Health aspects Humans Immunoglobulin A Immunoglobulin G Immunological memory Leukocytes, Mononuclear Lipopolysaccharides Medicine and Health Sciences Memory (Computers) Pathogens Peripheral blood mononuclear cells Prevention Research and Analysis Methods Shigella sonnei Shigella Vaccines Shigellosis Vaccination Vaccines Vaccines, Attenuated
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