Body temperature in the acute phase and clinical outcomes after acute ischemic stroke
This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months. We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning...
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| creator | Mezuki, Satomi Matsuo, Ryu Irie, Fumi Shono, Yuji Kuwashiro, Takahiro Sugimori, Hiroshi Wakisaka, Yoshinobu Ago, Tetsuro Kamouchi, Masahiro Kitazono, Takanari |
| description | This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months.
We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1‒36.5°C, Q2: 36.5‒36.7°C, Q3: 36.7‒36.8°C, Q4: 36.8‒37.1°C, and Q5: 37.1‒39.1°C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3-6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes.
The patient's mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65-0.99] vs. Q1) to Q5 (0.33 [0.28-0.40], P for trend |
| doi_str_mv | 10.1371/journal.pone.0296639 |
| format | Article |
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We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1‒36.5°C, Q2: 36.5‒36.7°C, Q3: 36.7‒36.8°C, Q4: 36.8‒37.1°C, and Q5: 37.1‒39.1°C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3-6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes.
The patient's mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65-0.99] vs. Q1) to Q5 (0.33 [0.28-0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03-1.79]) to Q5 (6.44 [5.19-8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1-3 and with longer duration with body temperature >37.0°C.
Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0296639</identifier><identifier>PMID: 38206979</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Biology and Life Sciences ; Body mass index ; Body Temperature ; Brain Ischemia - complications ; C-reactive protein ; Cardiac arrhythmia ; Care and treatment ; Clinical outcomes ; Cytokines ; Diabetes ; Diagnosis ; Evaluation ; Female ; Fever - complications ; High temperature ; Hospitalization ; Hospitals ; Humans ; Hypertension ; Infections ; Infectious diseases ; Ischemia ; Ischemic Stroke - complications ; Male ; Medicine and Health Sciences ; Metabolic disorders ; Proteins ; Regression analysis ; Statistical analysis ; Stroke ; Stroke (Disease) ; Stroke - complications ; Treatment Outcome</subject><ispartof>PloS one, 2024-01, Vol.19 (1), p.e0296639-e0296639</ispartof><rights>Copyright: © 2024 Mezuki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Mezuki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Mezuki et al 2024 Mezuki et al</rights><rights>2024 Mezuki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c642t-22076080b71bf2010868e2e64a1e55ac7f96666f76d7cffcb132b4279bd345923</cites><orcidid>0000-0002-9141-7068 ; 0000-0002-1836-9311 ; 0000-0002-7403-4188</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783745/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783745/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38206979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wiśniewski, Adam</contributor><creatorcontrib>Mezuki, Satomi</creatorcontrib><creatorcontrib>Matsuo, Ryu</creatorcontrib><creatorcontrib>Irie, Fumi</creatorcontrib><creatorcontrib>Shono, Yuji</creatorcontrib><creatorcontrib>Kuwashiro, Takahiro</creatorcontrib><creatorcontrib>Sugimori, Hiroshi</creatorcontrib><creatorcontrib>Wakisaka, Yoshinobu</creatorcontrib><creatorcontrib>Ago, Tetsuro</creatorcontrib><creatorcontrib>Kamouchi, Masahiro</creatorcontrib><creatorcontrib>Kitazono, Takanari</creatorcontrib><creatorcontrib>Fukuoka Stroke Registry Investigators</creatorcontrib><creatorcontrib>on behalf of the Fukuoka Stroke Registry Investigators</creatorcontrib><title>Body temperature in the acute phase and clinical outcomes after acute ischemic stroke</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months.
We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1‒36.5°C, Q2: 36.5‒36.7°C, Q3: 36.7‒36.8°C, Q4: 36.8‒37.1°C, and Q5: 37.1‒39.1°C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3-6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes.
The patient's mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65-0.99] vs. Q1) to Q5 (0.33 [0.28-0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03-1.79]) to Q5 (6.44 [5.19-8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1-3 and with longer duration with body temperature >37.0°C.
Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke.</description><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Body mass index</subject><subject>Body Temperature</subject><subject>Brain Ischemia - complications</subject><subject>C-reactive protein</subject><subject>Cardiac arrhythmia</subject><subject>Care and treatment</subject><subject>Clinical outcomes</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Evaluation</subject><subject>Female</subject><subject>Fever - complications</subject><subject>High temperature</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Ischemia</subject><subject>Ischemic Stroke - complications</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic disorders</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><subject>Stroke - 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complications</topic><topic>C-reactive protein</topic><topic>Cardiac arrhythmia</topic><topic>Care and treatment</topic><topic>Clinical outcomes</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Diagnosis</topic><topic>Evaluation</topic><topic>Female</topic><topic>Fever - complications</topic><topic>High temperature</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Ischemia</topic><topic>Ischemic Stroke - complications</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Metabolic disorders</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>Statistical analysis</topic><topic>Stroke</topic><topic>Stroke (Disease)</topic><topic>Stroke - complications</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mezuki, Satomi</creatorcontrib><creatorcontrib>Matsuo, Ryu</creatorcontrib><creatorcontrib>Irie, Fumi</creatorcontrib><creatorcontrib>Shono, Yuji</creatorcontrib><creatorcontrib>Kuwashiro, Takahiro</creatorcontrib><creatorcontrib>Sugimori, Hiroshi</creatorcontrib><creatorcontrib>Wakisaka, Yoshinobu</creatorcontrib><creatorcontrib>Ago, Tetsuro</creatorcontrib><creatorcontrib>Kamouchi, Masahiro</creatorcontrib><creatorcontrib>Kitazono, Takanari</creatorcontrib><creatorcontrib>Fukuoka Stroke Registry Investigators</creatorcontrib><creatorcontrib>on behalf of the Fukuoka Stroke Registry Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mezuki, Satomi</au><au>Matsuo, Ryu</au><au>Irie, Fumi</au><au>Shono, Yuji</au><au>Kuwashiro, Takahiro</au><au>Sugimori, Hiroshi</au><au>Wakisaka, Yoshinobu</au><au>Ago, Tetsuro</au><au>Kamouchi, Masahiro</au><au>Kitazono, Takanari</au><au>Wiśniewski, Adam</au><aucorp>Fukuoka Stroke Registry Investigators</aucorp><aucorp>on behalf of the Fukuoka Stroke Registry Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body temperature in the acute phase and clinical outcomes after acute ischemic stroke</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-01-11</date><risdate>2024</risdate><volume>19</volume><issue>1</issue><spage>e0296639</spage><epage>e0296639</epage><pages>e0296639-e0296639</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months.
We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1‒36.5°C, Q2: 36.5‒36.7°C, Q3: 36.7‒36.8°C, Q4: 36.8‒37.1°C, and Q5: 37.1‒39.1°C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3-6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes.
The patient's mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65-0.99] vs. Q1) to Q5 (0.33 [0.28-0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03-1.79]) to Q5 (6.44 [5.19-8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1-3 and with longer duration with body temperature >37.0°C.
Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38206979</pmid><doi>10.1371/journal.pone.0296639</doi><tpages>e0296639</tpages><orcidid>https://orcid.org/0000-0002-9141-7068</orcidid><orcidid>https://orcid.org/0000-0002-1836-9311</orcidid><orcidid>https://orcid.org/0000-0002-7403-4188</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_3069213899 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Biology and Life Sciences Body mass index Body Temperature Brain Ischemia - complications C-reactive protein Cardiac arrhythmia Care and treatment Clinical outcomes Cytokines Diabetes Diagnosis Evaluation Female Fever - complications High temperature Hospitalization Hospitals Humans Hypertension Infections Infectious diseases Ischemia Ischemic Stroke - complications Male Medicine and Health Sciences Metabolic disorders Proteins Regression analysis Statistical analysis Stroke Stroke (Disease) Stroke - complications Treatment Outcome |
| title | Body temperature in the acute phase and clinical outcomes after acute ischemic stroke |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T02%3A58%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Body%20temperature%20in%20the%20acute%20phase%20and%20clinical%20outcomes%20after%20acute%20ischemic%20stroke&rft.jtitle=PloS%20one&rft.au=Mezuki,%20Satomi&rft.aucorp=Fukuoka%20Stroke%20Registry%20Investigators&rft.date=2024-01-11&rft.volume=19&rft.issue=1&rft.spage=e0296639&rft.epage=e0296639&rft.pages=e0296639-e0296639&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0296639&rft_dat=%3Cgale_plos_%3EA779122730%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3069213899&rft_id=info:pmid/38206979&rft_galeid=A779122730&rft_doaj_id=oai_doaj_org_article_51f5353808164d91b62eced191db60af&rfr_iscdi=true |