Development of a sensitive real-time quaking-induced conversion (RT-QuIC) assay for application in prion-infected blood

Efforts to prevent human-to-human transmission of variant Creutzfeldt-Jakob disease (vCJD) by contaminated blood would be aided by the development of a sensitive diagnostic test that could be routinely used to screen blood donations. As blood samples from vCJD patients are extremely rare, here we de...

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Veröffentlicht in:	PloS one 2023-11, Vol.18 (11), p.e0293845-e0293845
Hauptverfasser:	Thomas, Charlotte M, Salamat, M. Khalid F, de Wolf, Christopher, McCutcheon, Sandra, Blanco, A. Richard Alejo, Manson, Jean C, Hunter, Nora, Houston, E. Fiona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal genetic engineering Animal models Assaying Asymptomatic Biology and Life Sciences Blood Blood & organ donations Blood banks Blood donors Blood tests Blood transfusions Body fluids Bovine spongiform encephalopathy Brain Brain research Care and treatment Cattle Comparative analysis Complications and side effects Creutzfeldt-Jakob disease Diagnosis Disease transmission Engineering and Technology Ethylenediaminetetraacetic acid Evaluation Ferric oxide Infection Infections Inoculation Iron compounds Iron oxides Medical screening Medical tests Medicine and Health Sciences Prion diseases Prion protein Prions Protein folding Proteins Real time Research and Analysis Methods Research ethics Sensitivity analysis Sheep Titration Transgenic mice
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