Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study, 2018-2020
In response to the 2015-2016 Zika virus (ZIKV) outbreak and the causal relationship established between maternal ZIKV infection and adverse infant outcomes, we conducted a cohort study to estimate the incidence of ZIKV infection in pregnancy and assess its impacts in women and infants. From May 2018...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2024-05, Vol.18 (5), p.e0012176 |
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| creator | Wongsawat, Jurai Thamthitiwat, Somsak Hicks, Victoria J Uttayamakul, Sumonmal Teepruksa, Phanthaneeya Sawatwong, Pongpun Skaggs, Beth Mock, Philip A MacArthur, John R Suya, Inthira Sapchookul, Patranuch Kitsutani, Paul Lo, Terrence Q Vachiraphan, Apichart Kovavisarach, Ekachai Rhee, Chulwoo Darun, Pamorn Saepueng, Kamol Waisaen, Chamnan Jampan, Doungporn Sriboonrat, Pravit Palanuwong, Buncha Sukbut, Punchawee Areechokchai, Darin Pittayawonganon, Chakrarat Iamsirithaworn, Sopon Bloss, Emily Rao, Carol Y |
| description | In response to the 2015-2016 Zika virus (ZIKV) outbreak and the causal relationship established between maternal ZIKV infection and adverse infant outcomes, we conducted a cohort study to estimate the incidence of ZIKV infection in pregnancy and assess its impacts in women and infants.
From May 2018-January 2020, we prospectively followed pregnant women recruited from 134 participating hospitals in two non-adjacent provinces in northeastern Thailand. We collected demographic, clinical, and epidemiologic data and blood and urine at routine antenatal care visits until delivery. ZIKV infections were confirmed by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). Specimens with confirmed ZIKV underwent whole genome sequencing. Among 3,312 women enrolled, 12 (0.36%) had ZIKV infections, of which two (17%) were detected at enrollment. Ten (83%, 3 in 2nd and 7 in 3rd trimester) ZIKV infections were detected during study follow-up, resulting in an infection rate of 0.15 per 1,000 person-weeks (95% CI: 0.07-0.28). The majority (11/12, 91.7%) of infections occurred in one province. Persistent ZIKV viremia (42 days) was found in only one woman. Six women with confirmed ZIKV infections were asymptomatic until delivery. Sequencing of 8 ZIKV isolates revealed all were of Asian lineage. All 12 ZIKV infected women gave birth to live, full-term infants; the only observed adverse birth outcome was low birth weight in one (8%) infant. Pregnancies in 3,300 ZIKV-rRT-PCR-negative women were complicated by 101 (3%) fetal deaths, of which 67 (66%) had miscarriages and 34 (34%) had stillbirths. There were no differences between adverse fetal or birth outcomes of live infants born to ZIKV-rRT-PCR-positive mothers compared to live infants born to ZIKV-rRT-PCR-negative mothers.
Confirmed ZIKV infections occurred infrequently in this large pregnancy cohort and observed adverse maternal and birth outcomes did not differ between mothers with and without confirmed infections. |
| doi_str_mv | 10.1371/journal.pntd.0012176 |
| format | Article |
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From May 2018-January 2020, we prospectively followed pregnant women recruited from 134 participating hospitals in two non-adjacent provinces in northeastern Thailand. We collected demographic, clinical, and epidemiologic data and blood and urine at routine antenatal care visits until delivery. ZIKV infections were confirmed by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). Specimens with confirmed ZIKV underwent whole genome sequencing. Among 3,312 women enrolled, 12 (0.36%) had ZIKV infections, of which two (17%) were detected at enrollment. Ten (83%, 3 in 2nd and 7 in 3rd trimester) ZIKV infections were detected during study follow-up, resulting in an infection rate of 0.15 per 1,000 person-weeks (95% CI: 0.07-0.28). The majority (11/12, 91.7%) of infections occurred in one province. Persistent ZIKV viremia (42 days) was found in only one woman. Six women with confirmed ZIKV infections were asymptomatic until delivery. Sequencing of 8 ZIKV isolates revealed all were of Asian lineage. All 12 ZIKV infected women gave birth to live, full-term infants; the only observed adverse birth outcome was low birth weight in one (8%) infant. Pregnancies in 3,300 ZIKV-rRT-PCR-negative women were complicated by 101 (3%) fetal deaths, of which 67 (66%) had miscarriages and 34 (34%) had stillbirths. There were no differences between adverse fetal or birth outcomes of live infants born to ZIKV-rRT-PCR-positive mothers compared to live infants born to ZIKV-rRT-PCR-negative mothers.
Confirmed ZIKV infections occurred infrequently in this large pregnancy cohort and observed adverse maternal and birth outcomes did not differ between mothers with and without confirmed infections.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0012176</identifier><identifier>PMID: 38758964</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Babies ; Biology and life sciences ; Birth weight ; Chikungunya virus ; Childbirth & labor ; Cohort analysis ; Consent ; DNA polymerases ; DNA sequencing ; Enrollments ; Epidemics ; Epidemiology ; Ethics ; Ethylenediaminetetraacetic acid ; Female ; Fetuses ; Gene sequencing ; Genomes ; Genomics ; Gestational age ; Guardians ; Health aspects ; Health facilities ; Hospitals ; Humans ; Incidence ; Infant, Newborn ; Infants ; Infants (Newborn) ; Infection ; Infections ; Low birth weight ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Microcephaly ; Neurological disorders ; Newborn babies ; Nucleotide sequence ; Nucleotide sequencing ; Parturition ; PCR ; People and Places ; Polymerase chain reaction ; Population ; Pregnancy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - virology ; Pregnancy Outcome ; Pregnant women ; Prospective Studies ; Public health ; Questionnaires ; Real time ; Risk Factors ; RNA-directed DNA polymerase ; Sequencing ; Surveillance ; Thailand - epidemiology ; Urine ; Vector-borne diseases ; Viremia ; Whole genome sequencing ; Womens health ; Young Adult ; Zika virus ; Zika Virus - genetics ; Zika Virus - isolation & purification ; Zika Virus Infection - epidemiology</subject><ispartof>PLoS neglected tropical diseases, 2024-05, Vol.18 (5), p.e0012176</ispartof><rights>Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c504t-83d59b896ecc75e38e2e34823744512b6661b84750ea3a393d21a782998036883</cites><orcidid>0000-0002-0177-0790</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139345/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139345/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38758964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wongsawat, Jurai</creatorcontrib><creatorcontrib>Thamthitiwat, Somsak</creatorcontrib><creatorcontrib>Hicks, Victoria J</creatorcontrib><creatorcontrib>Uttayamakul, Sumonmal</creatorcontrib><creatorcontrib>Teepruksa, Phanthaneeya</creatorcontrib><creatorcontrib>Sawatwong, Pongpun</creatorcontrib><creatorcontrib>Skaggs, Beth</creatorcontrib><creatorcontrib>Mock, Philip A</creatorcontrib><creatorcontrib>MacArthur, John R</creatorcontrib><creatorcontrib>Suya, Inthira</creatorcontrib><creatorcontrib>Sapchookul, Patranuch</creatorcontrib><creatorcontrib>Kitsutani, Paul</creatorcontrib><creatorcontrib>Lo, Terrence Q</creatorcontrib><creatorcontrib>Vachiraphan, Apichart</creatorcontrib><creatorcontrib>Kovavisarach, Ekachai</creatorcontrib><creatorcontrib>Rhee, Chulwoo</creatorcontrib><creatorcontrib>Darun, Pamorn</creatorcontrib><creatorcontrib>Saepueng, Kamol</creatorcontrib><creatorcontrib>Waisaen, Chamnan</creatorcontrib><creatorcontrib>Jampan, Doungporn</creatorcontrib><creatorcontrib>Sriboonrat, Pravit</creatorcontrib><creatorcontrib>Palanuwong, Buncha</creatorcontrib><creatorcontrib>Sukbut, Punchawee</creatorcontrib><creatorcontrib>Areechokchai, Darin</creatorcontrib><creatorcontrib>Pittayawonganon, Chakrarat</creatorcontrib><creatorcontrib>Iamsirithaworn, Sopon</creatorcontrib><creatorcontrib>Bloss, Emily</creatorcontrib><creatorcontrib>Rao, Carol Y</creatorcontrib><title>Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study, 2018-2020</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>In response to the 2015-2016 Zika virus (ZIKV) outbreak and the causal relationship established between maternal ZIKV infection and adverse infant outcomes, we conducted a cohort study to estimate the incidence of ZIKV infection in pregnancy and assess its impacts in women and infants.
From May 2018-January 2020, we prospectively followed pregnant women recruited from 134 participating hospitals in two non-adjacent provinces in northeastern Thailand. We collected demographic, clinical, and epidemiologic data and blood and urine at routine antenatal care visits until delivery. ZIKV infections were confirmed by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). Specimens with confirmed ZIKV underwent whole genome sequencing. Among 3,312 women enrolled, 12 (0.36%) had ZIKV infections, of which two (17%) were detected at enrollment. Ten (83%, 3 in 2nd and 7 in 3rd trimester) ZIKV infections were detected during study follow-up, resulting in an infection rate of 0.15 per 1,000 person-weeks (95% CI: 0.07-0.28). The majority (11/12, 91.7%) of infections occurred in one province. Persistent ZIKV viremia (42 days) was found in only one woman. Six women with confirmed ZIKV infections were asymptomatic until delivery. Sequencing of 8 ZIKV isolates revealed all were of Asian lineage. All 12 ZIKV infected women gave birth to live, full-term infants; the only observed adverse birth outcome was low birth weight in one (8%) infant. Pregnancies in 3,300 ZIKV-rRT-PCR-negative women were complicated by 101 (3%) fetal deaths, of which 67 (66%) had miscarriages and 34 (34%) had stillbirths. There were no differences between adverse fetal or birth outcomes of live infants born to ZIKV-rRT-PCR-positive mothers compared to live infants born to ZIKV-rRT-PCR-negative mothers.
Confirmed ZIKV infections occurred infrequently in this large pregnancy cohort and observed adverse maternal and birth outcomes did not differ between mothers with and without confirmed infections.</description><subject>Adult</subject><subject>Babies</subject><subject>Biology and life sciences</subject><subject>Birth weight</subject><subject>Chikungunya virus</subject><subject>Childbirth & labor</subject><subject>Cohort analysis</subject><subject>Consent</subject><subject>DNA polymerases</subject><subject>DNA sequencing</subject><subject>Enrollments</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Female</subject><subject>Fetuses</subject><subject>Gene sequencing</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Gestational age</subject><subject>Guardians</subject><subject>Health aspects</subject><subject>Health facilities</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infants (Newborn)</subject><subject>Infection</subject><subject>Infections</subject><subject>Low birth weight</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, Experimental</subject><subject>Microcephaly</subject><subject>Neurological disorders</subject><subject>Newborn babies</subject><subject>Nucleotide sequence</subject><subject>Nucleotide sequencing</subject><subject>Parturition</subject><subject>PCR</subject><subject>People and Places</subject><subject>Polymerase chain reaction</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Pregnancy Complications, Infectious - virology</subject><subject>Pregnancy Outcome</subject><subject>Pregnant 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facilities</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infants (Newborn)</topic><topic>Infection</topic><topic>Infections</topic><topic>Low birth weight</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Medicine, Experimental</topic><topic>Microcephaly</topic><topic>Neurological disorders</topic><topic>Newborn babies</topic><topic>Nucleotide sequence</topic><topic>Nucleotide sequencing</topic><topic>Parturition</topic><topic>PCR</topic><topic>People and Places</topic><topic>Polymerase chain reaction</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Pregnancy Complications, Infectious - virology</topic><topic>Pregnancy Outcome</topic><topic>Pregnant women</topic><topic>Prospective Studies</topic><topic>Public health</topic><topic>Questionnaires</topic><topic>Real time</topic><topic>Risk Factors</topic><topic>RNA-directed DNA polymerase</topic><topic>Sequencing</topic><topic>Surveillance</topic><topic>Thailand - epidemiology</topic><topic>Urine</topic><topic>Vector-borne diseases</topic><topic>Viremia</topic><topic>Whole genome sequencing</topic><topic>Womens health</topic><topic>Young Adult</topic><topic>Zika virus</topic><topic>Zika Virus - genetics</topic><topic>Zika Virus - isolation & purification</topic><topic>Zika Virus Infection - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wongsawat, Jurai</creatorcontrib><creatorcontrib>Thamthitiwat, Somsak</creatorcontrib><creatorcontrib>Hicks, Victoria J</creatorcontrib><creatorcontrib>Uttayamakul, Sumonmal</creatorcontrib><creatorcontrib>Teepruksa, Phanthaneeya</creatorcontrib><creatorcontrib>Sawatwong, Pongpun</creatorcontrib><creatorcontrib>Skaggs, Beth</creatorcontrib><creatorcontrib>Mock, Philip A</creatorcontrib><creatorcontrib>MacArthur, John R</creatorcontrib><creatorcontrib>Suya, Inthira</creatorcontrib><creatorcontrib>Sapchookul, Patranuch</creatorcontrib><creatorcontrib>Kitsutani, Paul</creatorcontrib><creatorcontrib>Lo, Terrence Q</creatorcontrib><creatorcontrib>Vachiraphan, Apichart</creatorcontrib><creatorcontrib>Kovavisarach, Ekachai</creatorcontrib><creatorcontrib>Rhee, Chulwoo</creatorcontrib><creatorcontrib>Darun, Pamorn</creatorcontrib><creatorcontrib>Saepueng, Kamol</creatorcontrib><creatorcontrib>Waisaen, Chamnan</creatorcontrib><creatorcontrib>Jampan, Doungporn</creatorcontrib><creatorcontrib>Sriboonrat, Pravit</creatorcontrib><creatorcontrib>Palanuwong, Buncha</creatorcontrib><creatorcontrib>Sukbut, Punchawee</creatorcontrib><creatorcontrib>Areechokchai, Darin</creatorcontrib><creatorcontrib>Pittayawonganon, Chakrarat</creatorcontrib><creatorcontrib>Iamsirithaworn, Sopon</creatorcontrib><creatorcontrib>Bloss, Emily</creatorcontrib><creatorcontrib>Rao, Carol Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wongsawat, Jurai</au><au>Thamthitiwat, Somsak</au><au>Hicks, Victoria J</au><au>Uttayamakul, Sumonmal</au><au>Teepruksa, Phanthaneeya</au><au>Sawatwong, Pongpun</au><au>Skaggs, Beth</au><au>Mock, Philip A</au><au>MacArthur, John R</au><au>Suya, Inthira</au><au>Sapchookul, Patranuch</au><au>Kitsutani, Paul</au><au>Lo, Terrence Q</au><au>Vachiraphan, Apichart</au><au>Kovavisarach, Ekachai</au><au>Rhee, Chulwoo</au><au>Darun, Pamorn</au><au>Saepueng, Kamol</au><au>Waisaen, Chamnan</au><au>Jampan, Doungporn</au><au>Sriboonrat, Pravit</au><au>Palanuwong, Buncha</au><au>Sukbut, Punchawee</au><au>Areechokchai, Darin</au><au>Pittayawonganon, Chakrarat</au><au>Iamsirithaworn, Sopon</au><au>Bloss, Emily</au><au>Rao, Carol Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study, 2018-2020</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>18</volume><issue>5</issue><spage>e0012176</spage><pages>e0012176-</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>In response to the 2015-2016 Zika virus (ZIKV) outbreak and the causal relationship established between maternal ZIKV infection and adverse infant outcomes, we conducted a cohort study to estimate the incidence of ZIKV infection in pregnancy and assess its impacts in women and infants.
From May 2018-January 2020, we prospectively followed pregnant women recruited from 134 participating hospitals in two non-adjacent provinces in northeastern Thailand. We collected demographic, clinical, and epidemiologic data and blood and urine at routine antenatal care visits until delivery. ZIKV infections were confirmed by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). Specimens with confirmed ZIKV underwent whole genome sequencing. Among 3,312 women enrolled, 12 (0.36%) had ZIKV infections, of which two (17%) were detected at enrollment. Ten (83%, 3 in 2nd and 7 in 3rd trimester) ZIKV infections were detected during study follow-up, resulting in an infection rate of 0.15 per 1,000 person-weeks (95% CI: 0.07-0.28). The majority (11/12, 91.7%) of infections occurred in one province. Persistent ZIKV viremia (42 days) was found in only one woman. Six women with confirmed ZIKV infections were asymptomatic until delivery. Sequencing of 8 ZIKV isolates revealed all were of Asian lineage. All 12 ZIKV infected women gave birth to live, full-term infants; the only observed adverse birth outcome was low birth weight in one (8%) infant. Pregnancies in 3,300 ZIKV-rRT-PCR-negative women were complicated by 101 (3%) fetal deaths, of which 67 (66%) had miscarriages and 34 (34%) had stillbirths. There were no differences between adverse fetal or birth outcomes of live infants born to ZIKV-rRT-PCR-positive mothers compared to live infants born to ZIKV-rRT-PCR-negative mothers.
Confirmed ZIKV infections occurred infrequently in this large pregnancy cohort and observed adverse maternal and birth outcomes did not differ between mothers with and without confirmed infections.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38758964</pmid><doi>10.1371/journal.pntd.0012176</doi><orcidid>https://orcid.org/0000-0002-0177-0790</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2024-05, Vol.18 (5), p.e0012176 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_3069186306 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Public Library of Science (PLoS) |
| subjects | Adult Babies Biology and life sciences Birth weight Chikungunya virus Childbirth & labor Cohort analysis Consent DNA polymerases DNA sequencing Enrollments Epidemics Epidemiology Ethics Ethylenediaminetetraacetic acid Female Fetuses Gene sequencing Genomes Genomics Gestational age Guardians Health aspects Health facilities Hospitals Humans Incidence Infant, Newborn Infants Infants (Newborn) Infection Infections Low birth weight Medical research Medicine and Health Sciences Medicine, Experimental Microcephaly Neurological disorders Newborn babies Nucleotide sequence Nucleotide sequencing Parturition PCR People and Places Polymerase chain reaction Population Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - virology Pregnancy Outcome Pregnant women Prospective Studies Public health Questionnaires Real time Risk Factors RNA-directed DNA polymerase Sequencing Surveillance Thailand - epidemiology Urine Vector-borne diseases Viremia Whole genome sequencing Womens health Young Adult Zika virus Zika Virus - genetics Zika Virus - isolation & purification Zika Virus Infection - epidemiology |
| title | Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study, 2018-2020 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T01%3A47%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characteristics,%20risk%20factors,%20and%20outcomes%20related%20to%20Zika%20virus%20infection%20during%20pregnancy%20in%20Northeastern%20Thailand:%20A%20prospective%20pregnancy%20cohort%20study,%202018-2020&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Wongsawat,%20Jurai&rft.date=2024-05-01&rft.volume=18&rft.issue=5&rft.spage=e0012176&rft.pages=e0012176-&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0012176&rft_dat=%3Cgale_plos_%3EA796130723%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3069186306&rft_id=info:pmid/38758964&rft_galeid=A796130723&rft_doaj_id=oai_doaj_org_article_d90dafd82bff490384fc5ea7443261e5&rfr_iscdi=true |