Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease

Prion diseases uniquely manifest in three distinct forms: inherited, sporadic, and infectious. Wild-type prions are responsible for the sporadic and infectious versions, while mutant prions cause inherited variants like fatal familial insomnia (FFI) and familial Creutzfeldt-Jakob disease (fCJD). Alt...

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Veröffentlicht in:	PLoS pathogens 2024-04, Vol.20 (4), p.e1012087
Hauptverfasser:	Walsh, Daniel J, Rees, Judy R, Mehra, Surabhi, Bourkas, Matthew E C, Kaczmarczyk, Lech, Stuart, Erica, Jackson, Walker S, Watts, Joel C, Supattapone, Surachai
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Arvicolinae - metabolism Biology and Life Sciences Brain - pathology Brain research Cellulose Cellulose ethers Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - drug therapy Creutzfeldt-Jakob Syndrome - genetics Creutzfeldt-Jakob Syndrome - metabolism Disease Drug dosages Drug resistance Drug therapy Drugs Ethylenediaminetetraacetic acid Gene mutations Genetic aspects Health aspects Insomnia Laboratory animals Medicine and Health Sciences Mice Mutants Mutation Neomycin Neuropathology Physical Sciences Physiological aspects Prion diseases Prion Diseases - drug therapy Prion Diseases - genetics Prion Diseases - metabolism Prion protein Prion Proteins - genetics Prion Proteins - metabolism Prions Prions - metabolism Proteins Quinacrine Research and Analysis Methods Sleep disorders Stem cells Survival
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