Clonorchis sinensis infection amplifies hepatocellular carcinoma stemness, predicting unfavorable prognosis

Extensive evidence links Clonorchis sinensis (C. sinensis) to cholangiocarcinoma; however, its association with hepatocellular carcinoma (HCC) is less acknowledged, and the underlying mechanism remains unclear. This study was designed to investigate the association between C. sinensis infection and...

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Veröffentlicht in:	PLoS neglected tropical diseases 2024-01, Vol.18 (1), p.e0011906
Hauptverfasser:	Lin, Qiumei, Tang, Zeli, Qin, Yuling, Deng, Xueling, Wei, Caibiao, Liu, Fengfei, Pan, Xiaolan, Liu, Dengyu, Zhan, Tingzheng, Fang, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Fetoproteins - analysis alpha-Fetoproteins - metabolism Animals Antigens Bile Duct Neoplasms Bile ducts Bile Ducts, Intrahepatic - chemistry Bile Ducts, Intrahepatic - metabolism Bile Ducts, Intrahepatic - pathology Biology and Life Sciences CA-19-9 Antigen Cancer Cancer therapies Carbohydrates Carcinogens Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Cardiovascular disease Care and treatment China - epidemiology Cholangiocarcinoma Cirrhosis Clonorchiasis - complications Clonorchis sinensis Clonorchis sinensis - metabolism Complement component C3 Complement component C4 Data collection Eosinophils Epithelial Cell Adhesion Molecule Ethics Fibrosis Gender Hematology Hepatectomy Hepatitis Hepatocellular carcinoma Hepatoma Hospitals Humans Immunohistochemistry Infections Leukocytes (eosinophilic) Liver cancer Liver cirrhosis Liver Cirrhosis - pathology Liver Neoplasms - complications Liver Neoplasms - pathology Lymphocytes Male Medical prognosis Medicine and Health Sciences Metastasis Mortality Multivariate analysis Neoplasm Staging Neoplasms Parasites Patient outcomes Patients Prognosis Regression analysis Retrospective Studies Risk factors Sialyl Lewis a antigen Statistical analysis Stem cells Survival Tumors α-Fetoprotein
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