Deciphering infected cell types, hub gene networks and cell-cell communication in infectious bronchitis virus via single-cell RNA sequencing

Infectious bronchitis virus (IBV) is a coronavirus that infects chickens, which exhibits a broad tropism for epithelial cells, infecting the tracheal mucosal epithelium, intestinal mucosal epithelium, and renal tubular epithelial cells. Utilizing single-cell RNA sequencing (scRNA-seq), we systematic...

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Veröffentlicht in:	PLoS pathogens 2024-05, Vol.20 (5), p.e1012232-e1012232
Hauptverfasser:	Liukang, Chengyin, Zhao, Jing, Tian, Jiaxin, Huang, Min, Liang, Rong, Zhao, Ye, Zhang, Guozhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis B cells Bronchitis Care and treatment Cell Communication Cell interactions Cells Chickens Collecting duct Coronavirus Infections - genetics Coronavirus Infections - virology Coronaviruses Diagnosis Disease susceptibility Disease transmission Distal tubules Epithelial cells Epithelial Cells - metabolism Epithelial Cells - virology Epithelium Gene expression Gene Regulatory Networks Gene sequencing Genes Genomics Immunofluorescence Immunology Infections Infectious bronchitis virus - genetics Infectious bronchitis virus - physiology Inflammation Investigations Kidneys Macrophages Modules Mucosa Network analysis Pathogenesis Populations Poultry Poultry Diseases - genetics Poultry Diseases - immunology Poultry Diseases - virology Proteins Ribonucleic acid RNA RNA polymerase RNA sequencing RNA viruses Sequence Analysis, RNA Single-Cell Analysis Tropism Viral infections
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