Deficiency in astrocyte CCL2 production reduces neuroimmune control of Toxoplasma gondii infection

Toxoplasma gondii is an obligate intracellular parasite that infects one-third of the world's human population and establishes infection in the brain. Cerebral immune cell infiltration is critical for controlling the parasite, but little is known about the molecular cues guiding immune cells to...

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Veröffentlicht in:	PLoS pathogens 2024-01, Vol.20 (1), p.e1011710
Hauptverfasser:	Orchanian, Stephanie B, Still, Katherine, Harris, Tajie H, Lodoen, Melissa B
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Astrocytes Astrocytes - metabolism Biology and Life Sciences Brain Brain - metabolism CD4 antigen Chemokine CCL2 - metabolism Chemokines Chronic infection Confocal microscopy Engineering and Technology Flow cytometry Glial fibrillary acidic protein Health aspects Human populations Humans Immune response Immune system Infection Infection control Infections Inflammation Intracellular Lymphocytes Lymphocytes T Medicine and Health Sciences Methods Mice Mice, Inbred C57BL Mice, Knockout Microglia Microscopy Monocyte chemoattractant protein 1 Monocytes Myeloid cells Nitric-oxide synthase Parasite control Parasites Parasitic diseases Prevention Production increases Proteins Protozoa Risk factors T cells Toxoplasma - metabolism Toxoplasma gondii Toxoplasmosis Toxoplasmosis - metabolism
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