Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses

Alongshan virus (ALSV), a newly discovered member of unclassified Flaviviridae family, is able to infect humans. ALSV has a multi-segmented genome organization and is evolutionarily distant from canonical mono-segmented flaviviruses. The virus-encoded methyltransferase (MTase) plays an important rol...

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Veröffentlicht in:	PLoS pathogens 2023-10, Vol.19 (10), p.e1011694-e1011694
Hauptverfasser:	Chen, Hua, Lin, Sheng, Yang, Fanli, Chen, Zimin, Guo, Liyan, Yang, Jing, Lin, Xi, Wang, Lingling, Duan, Yanping, Wen, Ao, Zhang, Xindan, Dai, Yushan, Yin, Keqing, Yuan, Xin, Yu, Chongzhang, He, Yarong, He, Bin, Cao, Yu, Dong, Haohao, Li, Jian, Zhao, Qi, Liu, Quan, Lu, Guangwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino acids Analysis Antiviral agents Arachnids Binding Biology and life sciences Crystals Dengue fever Dosage and administration Drug development E coli Encephalitis Enzymes Flaviviridae Genomes Genomics Homocysteine Hydrogen Hydrogen bonding Hydrogen bonds L-Homocysteine Ligands Medicine and Health Sciences Methionine Methyltransferase Methyltransferases Mutagenesis Peptides Physical Sciences Proteins Research and Analysis Methods RNA polymerase Structure Structure-function relationships Viral infections Viruses
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