Dual function of Zika virus NS2B-NS3 protease

Zika virus (ZIKV) serine protease, indispensable for viral polyprotein processing and replication, is composed of the membrane-anchored NS2B polypeptide and the N-terminal domain of the NS3 polypeptide (NS3pro). The C-terminal domain of the NS3 polypeptide (NS3hel) is necessary for helicase activity...

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Veröffentlicht in:	PLoS pathogens 2023-11, Vol.19 (11), p.e1011795-e1011795
Hauptverfasser:	Shiryaev, Sergey A, Cieplak, Piotr, Cheltsov, Anton, Liddington, Robert C, Terskikh, Alexey V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Aprotinin Binding sites Competition Conformation Crystal structure Crystallization Dengue fever DNA helicase Domains Electron microscopes Encephalitis Guillain-Barre syndrome Hepatitis C Humans Infections Peptides Polypeptides Protease Protease Inhibitors Proteases Proteins Ribonucleic acid RNA RNA helicase Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Serine proteinase Substrate inhibition Vector-borne diseases Viral Nonstructural Proteins - metabolism West Nile virus Zika virus Zika Virus - genetics Zika Virus Infection
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