Unanticipated domain requirements for Drosophila Wnk kinase in vivo

WNK (With no Lysine [K]) kinases have critical roles in the maintenance of ion homeostasis and the regulation of cell volume. Their overactivation leads to pseudohypoaldosteronism type II (Gordon syndrome) characterized by hyperkalemia and high blood pressure. More recently, WNK family members have...

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Veröffentlicht in:	PLoS genetics 2023-10, Vol.19 (10), p.e1010975-e1010975
Hauptverfasser:	Yarikipati, Prathibha, Jonusaite, Sima, Pleinis, John M, Dominicci Cotto, Carihann, Sanchez-Hernandez, David, Morrison, Daryl E, Goyal, Suhani, Schellinger, Jeffrey, Pénalva, Clothilde, Curtiss, Jennifer, Rodan, Aylin R, Jenny, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Analysis Angiogenesis Animals Biology and Life Sciences Blood pressure C-Terminus Cardiovascular system Cell culture Cell size Drosophila Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Genetic aspects Homeostasis Humans Hyperkalemia Hypertension Identification and classification Insects Kinases Malpighian tubules Medicine and Health Sciences Mutation Nervous system Phase transitions Phosphotransferases Physical Sciences Potassium Properties Protein Serine-Threonine Kinases - metabolism Pseudohypoaldosteronism Research and Analysis Methods Structure Structure-function relationships Transcription factors Wildlife conservation WNK Lysine-Deficient Protein Kinase 1 - genetics Wnt protein Zebrafish - metabolism
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