sc2MeNetDrug: A computational tool to uncover inter-cell signaling targets and identify relevant drugs based on single cell RNA-seq data

Single-cell RNA sequencing (scRNA-seq) is a powerful technology to investigate the transcriptional programs in stromal, immune, and disease cells, like tumor cells or neurons within the Alzheimer's Disease (AD) brain or tumor microenvironment (ME) or niche. Cell-cell communications within ME pl...

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Veröffentlicht in:	PLoS computational biology 2024-01, Vol.20 (1), p.e1011785-e1011785
Hauptverfasser:	Feng, Jiarui, Goedegebuure, S Peter, Zeng, Amanda, Bi, Ye, Wang, Ting, Payne, Philip, Ding, Li, DeNardo, David, Hawkins, William, Fields, Ryan C, Li, Fuhai
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Alzheimer's disease Annotations Biology and Life Sciences Biomarkers Brain tumors Cancer therapies Cell signaling Cells Cellular signal transduction Clustering Communication Communication networks Communications Computational neuroscience Computer and Information Sciences Data analysis Design Development and progression Drug development Drug discovery Drugs Electronic data processing Gene sequencing Genes Genetic transcription Graphical user interface Health aspects Heterogeneity Immunosuppressive agents Immunotherapy Ligands Medicine and Health Sciences Methods Neurodegenerative diseases Neurons Ontology Pancreatic cancer Quality control Research and Analysis Methods RNA RNA sequencing Signaling Software Target recognition Technology application Therapeutic targets Tumor cells Tumor microenvironment Tumors User interface
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