A role for the C. elegans Argonaute protein CSR-1 in small nuclear RNA 3' processing

The Integrator is a multi-subunit protein complex that catalyzes the maturation of snRNA transcripts via 3' cleavage, a step required for snRNA incorporation with snRNP for spliceosome biogenesis. Here we developed a GFP based in vivo snRNA misprocessing reporter as a readout of Integrator func...

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Veröffentlicht in:	PLoS genetics 2024-05, Vol.20 (5), p.e1011284
Hauptverfasser:	Waddell, Brandon M, Wu, Cheng-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Alternative Splicing - genetics Analysis Animals Argonaute Proteins - genetics Argonaute Proteins - metabolism Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Catalytic subunits Cloning Corporate social responsibility Genes Genetic aspects Genetic transcription Genomes Genomics Identification and classification Messenger RNA Mutation Proteins Ribonucleoproteins (small nuclear) RNA Interference RNA polymerase RNA processing RNA Processing, Post-Transcriptional RNA sequencing RNA, Small Nuclear - genetics RNA, Small Nuclear - metabolism RNA-mediated interference snRNA Spliceosomes - genetics Spliceosomes - metabolism Transcriptomes
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