Checkpoint phosphorylation sites on budding yeast Rif1 protect nascent DNA from degradation by Sgs1-Dna2

In budding yeast the Rif1 protein is important for protecting nascent DNA at blocked replication forks, but the mechanism has been unclear. Here we show that budding yeast Rif1 must interact with Protein Phosphatase 1 to protect nascent DNA. In the absence of Rif1, removal of either Dna2 or Sgs1 pre...

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Veröffentlicht in:	PLoS genetics 2023-11, Vol.19 (11), p.e1011044-e1011044
Hauptverfasser:	Gali, Vamsi Krishna, Monerawela, Chandre, Laksir, Yassine, Hiraga, Shin-Ichiro, Donaldson, Anne D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Binding proteins Biodegradation Brewer's yeast Cell cycle Cell Cycle Checkpoints Cells Chemical properties Conserved sequence Deoxyribonucleic acid DNA DNA biosynthesis DNA helicase DNA Helicases - metabolism DNA Replication Genetic aspects Genetic research Genomes Genomic Instability Genomics Kinases Nuclease Nucleotide sequence Phosphatase Phosphatases Phosphoprotein phosphatase Phosphorylation Physiological aspects Protection and preservation Protein phosphatase Proteins Proteolysis Replication forks Repressor Proteins - metabolism RNA Helicases - metabolism S phase Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Telomere-Binding Proteins - metabolism Yeast
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