Nonhomologous tails direct heteroduplex rejection and mismatch correction during single-strand annealing in Saccharomyces cerevisiae

Single-strand annealing (SSA) is initiated when a double strand break (DSB) occurs between two flanking repeated sequences, resulting in a deletion that leaves a single copy of the repeat. We studied budding yeast strains carrying two 200-bp URA3 sequences separated by 2.6 kb of spacer DNA (phage la...

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Veröffentlicht in:	PLoS genetics 2024-02, Vol.20 (2), p.e1010527-e1010527
Hauptverfasser:	Sapède, Elena, Sugawara, Neal, Tyers, Randall G, Nakajima, Yuko, Afreen, Mosammat Faria, Romero Escobar, Jesselin, Haber, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	Annealing Biology and life sciences Brewer's yeast DNA helicase DNA repair DNA sequencing Double-strand break repair Genetic aspects Genetic research Genomes MLH1 protein MSH2 protein MSH6 protein Mutation Nucleotide sequence Physical Sciences Physiological aspects Proteins Rad1 protein Rad52 protein Research and Analysis Methods Sequence analysis Standard deviation Stem cells Unwinding Yeast
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