A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii

CRISPR-based gene drives offer promising prospects for controlling disease-transmitting vectors and agricultural pests. A significant challenge for successful suppression-type drive is the rapid evolution of resistance alleles. One approach to mitigate the development of resistance involves targetin...

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Veröffentlicht in:	PLoS genetics 2024-04, Vol.20 (4), p.e1011226-e1011226
Hauptverfasser:	Ma, Suhan, Ni, Xuyang, Chen, Shimin, Qiao, Xiaomu, Xu, Xuejiao, Chen, Weizhe, Champer, Jackson, Huang, Jia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biological research Biology and Life Sciences Biology, Experimental Chromosomes Control CRISPR CRISPR-Cas Systems Drosophila Drosophila - genetics Drosophila melanogaster - genetics Drosophila suzukii Egg laying Female Females Fruit Gene Drive Technology Gene polymorphism Genetic aspects Genetic engineering Genotype & phenotype gRNA Humans Infertility Infertility in animals Infertility, Female - genetics Insects Males Octopamine Pest resistance Pests Phenotype Phenotypes Population genetics Research and Analysis Methods RNA, Guide, CRISPR-Cas Systems Sterility Suppression, Genetic Transgenes Tyrosine decarboxylase Vectors
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