Lytic bacteriophages induce the secretion of antiviral and proinflammatory cytokines from human respiratory epithelial cells

Phage therapy is a therapeutic approach to treat multidrug-resistant (MDR) infections that employs lytic bacteriophages (phages) to eliminate bacteria. Despite the abundant evidence for its success as an antimicrobial in Eastern Europe, there is scarce data regarding its effects on the human host. H...

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Veröffentlicht in:	PLoS biology 2024-04, Vol.22 (4), p.e3002566-e3002566
Hauptverfasser:	Zamora, Paula F, Reidy, Thomas G, Armbruster, Catherine R, Sun, Ming, Van Tyne, Daria, Turner, Paul E, Koff, Jonathan L, Bomberger, Jennifer M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antiviral drugs Bacteria Bacteriophages Bacteriophages - genetics Bacteriophages - physiology Biofilms Biology and Life Sciences Cardiopulmonary system Clinical trials Cystic fibrosis Cystic Fibrosis - immunology Cystic Fibrosis - metabolism Cystic Fibrosis - therapy Cytokines Cytokines - metabolism Epithelial cells Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - virology Epithelium Humans Infections Inflammation Mammals Medicine and Health Sciences Microenvironments Morphology Multidrug resistance Phage Therapy Phages Physiochemistry Physiological aspects Pseudomonas aeruginosa - virology Pseudomonas Infections - immunology Pseudomonas Infections - therapy Pseudomonas Phages - metabolism Respiratory diseases Respiratory Mucosa - immunology Respiratory Mucosa - metabolism Respiratory Mucosa - virology Respiratory organs Respiratory tract Therapy Transmission electron microscopy
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