Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication

Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the cofactor and Interferon antagonist VP35. We previously showed that the covalent ubiquitination...

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Veröffentlicht in:	PLoS biology 2024-02, Vol.22 (2), p.e3002544
Hauptverfasser:	Rodríguez-Salazar, Carlos A, van Tol, Sarah, Mailhot, Olivier, Gonzalez-Orozco, Maria, Galdino, Gabriel T, Warren, Abbey N, Teruel, Natalia, Behera, Padmanava, Afreen, Kazi Sabrina, Zhang, Lihong, Juelich, Terry L, Smith, Jennifer K, Zylber, María Inés, Freiberg, Alexander N, Najmanovich, Rafael J, Giraldo, Maria I, Rajsbaum, Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Addition polymerization Analysis Animals Chemical compounds Covalence Ebola virus Ebolavirus Ebolavirus - genetics Ectopic expression Genetic aspects Genomes Hemorrhagic fever Hemorrhagic Fever, Ebola Humans Identification and classification Methods Mice Molecular weight Nucleocapsid Proteins Proteins Replication RNA polymerase Ubiquitin Ubiquitin - metabolism Ubiquitin-proteasome system Ubiquitination Viral diseases Viral Regulatory and Accessory Proteins Virus Replication - genetics Viruses
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