Resurrection of 2'-5'-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication

The prenylated form of the human 2'-5'-oligoadenylate synthetase 1 (OAS1) protein has been shown to potently inhibit the replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic. However, the OAS...

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Veröffentlicht in:	PLoS biology 2023-11, Vol.21 (11), p.e3002398
Hauptverfasser:	Lytras, Spyros, Wickenhagen, Arthur, Sugrue, Elena, Stewart, Douglas G, Swingler, Simon, Sims, Anna, Jackson Ireland, Hollie, Davies, Emma L, Ludlam, Eliza M, Li, Zhuonan, Hughes, Joseph, Wilson, Sam J
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - genetics Ablation Amino acid sequence Analysis Animals Antiviral activity Bat protein Bats Biology and life sciences Chiroptera Coronaviruses COVID-19 Disease transmission Entropy Evolution Gene expression Genetic aspects Genomes Humans Identification and classification Ligases Medicine and health sciences Pandemics Phylogenetics Phylogeny Physical Sciences Properties Protein structure Protein structure prediction Proteins Replication Research and Analysis Methods Rhinolophoidea SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Short Reports Viral diseases Viruses
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