$Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples$

Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples

Precise analysis of tissue DNA and RNA samples is often hampered by contaminating non-target cells whose amounts are highly variable. DNA methylation profiles are specific to cell types, and can be utilized for assessment of the fraction of such contaminating non-target cells. Here, we aimed 1) to i...

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Veröffentlicht in:	PloS one 2023-10, Vol.18 (10), p.e0290034-e0290034
Hauptverfasser:	Nishiyama, Kazuhiro, Nishinakamura, Hitomi, Takeshima, Hideyuki, Yuyu, Liu, Takeuchi, Chihiro, Hattori, Naoko, Takeda, Haruna, Yamashita, Satoshi, Wakabayashi, Mika, Sato, Kotomi, Obama, Kazutaka, Ushijima, Toshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Biology and life sciences Biomarkers CD4 antigen CD45 antigen CD8 antigen Cluster analysis Clustering Colitis Colon Contamination Coronary vessels CpG islands Dendritic cells Deoxyribonucleic acid Dextran Dextran sulfate Dextrans DNA DNA methylation Enhancers Evaluation Flow cytometry Fluorescence Gene expression Genes Genetic testing Genomes Genomics Inflammation Leukocytes Lymphocytes Lymphocytes B Lymphocytes T Medicine and Health Sciences Methylation Neutrophils Physical Sciences Research and Analysis Methods RNA Sodium Software Spleen Sulfates Tissue analysis Tissues
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