The clinical value of hsa-miR-190b-5p in peripheral blood of pediatric β-thalassemia and its regulation on BCL11A expression

Background The B cell CLL/lymphoma 11A (BCL11A) is a key regulator of hemoglobin switching in β-thalassemia (β-thal). Previous study has suggested that dysregulated microRNAs are involved in the regulation of BCL11A expression. The aim of this study was to investigate the clinical value of hsa-miR-1...

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Veröffentlicht in:	PloS one 2023-10, Vol.18 (10), p.e0292031-e0292031
Hauptverfasser:	Chen, Meihuan, Wang, Xinrui, Wang, Haiwei, Zhang, Min, Chen, Lingji, Chen, Hong, Pan, Yali, Zhang, Yanhong, Xu, Liangpu, Huang, Hailong
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Anemia Antibodies Binding sites Biology and Life Sciences Biomarkers Blood Blood diseases Chromosome 5 Chronic lymphocytic leukemia Correlation Diagnostic systems Epigenetics Gene expression Hematology Hemoglobin Lymphoma Medicine and Health Sciences MicroRNAs miRNA Pediatrics Peripheral blood Proteins Research and analysis methods Software Thalassemia Transcription factors
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