The endocytic receptor protein LRP-1 modulate P-glycoprotein mediated drug resistance in MCF-7 cells

Multidrug resistance (MDR) is a major obstacle to successful cancer chemotherapy. A typical form of MDR is due to the overexpression of membrane transport proteins., such as Glycoprotein-P (P-gp), resulting in an increased drug efflux preventing drug cytotoxicity. P-gp is mainly localized on the pla...

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Veröffentlicht in:	PloS one 2023-09, Vol.18 (9), p.e0285834-e0285834
Hauptverfasser:	Henry, Aubery, Mauperin, Marine, Devy, Jerome, Dedieu, Stephane, Chazee, Lise, Hachet, Cathy, Terryn, Christine, Duca, Laurent, Martiny, Laurent, Devarenne-Charpentier, Emmanuelle, Btaouri, Hassan El
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Aprotinin Biology and Life Sciences Breast cancer Cancer Care and treatment Carrier proteins Cell surface Cells Chemotherapy Cytotoxicity Density Development and progression Doxorubicin Drug resistance Drug resistance in microorganisms Efflux Endocytosis Endoplasmic reticulum Endosomes Ethylenediaminetetraacetic acid Extracellular matrix Glycoproteins Golgi apparatus Health aspects LAMP-1 protein Ligands Low density lipoproteins Lysosomes Medicine and Health Sciences Membranes Multidrug resistance P-Glycoprotein Plasma Protein transport Proteins Receptor density Receptors Research and Analysis Methods Sequestering Signal transduction Substrates Thyroid cancer
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