Suppression of migration and invasion by taraxerol in the triple-negative breast cancer cell line MDA-MB-231 via the ERK/Slug axis
As one of the triterpene extracts of Taraxacum, a traditional Chinese plant, taraxerol (TRX) exhibits antitumor activity. In this study, we evaluated the effects of TRX on the migration and invasion of MDA-MB-231 cells, analyzed the molecular mechanism through network pharmacology and molecular dock...
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| Veröffentlicht in: | PloS one 2023-09, Vol.18 (9), p.e0291693-e0291693 |
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| creator | Xia, Yu-ting Zhang, Yu-qin Chen, Lu Min, Liangliang Huang, Da Zhang, Yulu Li, Cong Li, Zhi-hua |
| description | As one of the triterpene extracts of Taraxacum, a traditional Chinese plant, taraxerol (TRX) exhibits antitumor activity. In this study, we evaluated the effects of TRX on the migration and invasion of MDA-MB-231 cells, analyzed the molecular mechanism through network pharmacology and molecular docking, and finally verified it by in vitro experiments. The results showed that TRX could inhibit the migration and invasion of MDA-MB-231 cells in a time- and concentration-dependent manner, while MAPK3 was the most promising target and could stably combine with TRX. In addition, the relative protein expression levels were detected by Western blot, and we observed that TRX could inhibit the migration and invasion of MDA-MB-231 cells via the ERK/Slug axis. Moreover, an ERK activator (tert-butylhydroquinone, tBHQ) partially reversed the suppressive effect of TRX on MDA-MB-231 cells. In conclusion, TRX inhibited the migration and invasion of MDA-MB-231 cells via the ERK/Slug axis. |
| doi_str_mv | 10.1371/journal.pone.0291693 |
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In this study, we evaluated the effects of TRX on the migration and invasion of MDA-MB-231 cells, analyzed the molecular mechanism through network pharmacology and molecular docking, and finally verified it by in vitro experiments. The results showed that TRX could inhibit the migration and invasion of MDA-MB-231 cells in a time- and concentration-dependent manner, while MAPK3 was the most promising target and could stably combine with TRX. In addition, the relative protein expression levels were detected by Western blot, and we observed that TRX could inhibit the migration and invasion of MDA-MB-231 cells via the ERK/Slug axis. Moreover, an ERK activator (tert-butylhydroquinone, tBHQ) partially reversed the suppressive effect of TRX on MDA-MB-231 cells. In conclusion, TRX inhibited the migration and invasion of MDA-MB-231 cells via the ERK/Slug axis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0291693</identifier><identifier>PMID: 37751436</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Antibodies ; Anticancer properties ; Antitumor activity ; Bioinformatics ; Biology and Life Sciences ; Breast cancer ; Cancer cells ; Cancer therapies ; Care and treatment ; Cell adhesion & migration ; Cell growth ; Diagnosis ; Health aspects ; Ligands ; Medical prognosis ; Medical research ; Medicine and Health Sciences ; Metastasis ; Molecular docking ; Molecular modelling ; Pharmacology ; Physical Sciences ; Proteins ; Research and Analysis Methods ; Software ; Statistical analysis ; t-Butylhydroquinone ; Wound healing</subject><ispartof>PloS one, 2023-09, Vol.18 (9), p.e0291693-e0291693</ispartof><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Xia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Xia et al 2023 Xia et al</rights><rights>2023 Xia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c670t-be4ca5c14553c2ca20e6505f805d7ad6988a1e635cdda0c8c6e92703a6a23c3c3</citedby><cites>FETCH-LOGICAL-c670t-be4ca5c14553c2ca20e6505f805d7ad6988a1e635cdda0c8c6e92703a6a23c3c3</cites><orcidid>0000-0002-4302-389X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522031/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522031/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids></links><search><creatorcontrib>Xia, Yu-ting</creatorcontrib><creatorcontrib>Zhang, Yu-qin</creatorcontrib><creatorcontrib>Chen, Lu</creatorcontrib><creatorcontrib>Min, Liangliang</creatorcontrib><creatorcontrib>Huang, Da</creatorcontrib><creatorcontrib>Zhang, Yulu</creatorcontrib><creatorcontrib>Li, Cong</creatorcontrib><creatorcontrib>Li, Zhi-hua</creatorcontrib><title>Suppression of migration and invasion by taraxerol in the triple-negative breast cancer cell line MDA-MB-231 via the ERK/Slug axis</title><title>PloS one</title><description>As one of the triterpene extracts of Taraxacum, a traditional Chinese plant, taraxerol (TRX) exhibits antitumor activity. In this study, we evaluated the effects of TRX on the migration and invasion of MDA-MB-231 cells, analyzed the molecular mechanism through network pharmacology and molecular docking, and finally verified it by in vitro experiments. The results showed that TRX could inhibit the migration and invasion of MDA-MB-231 cells in a time- and concentration-dependent manner, while MAPK3 was the most promising target and could stably combine with TRX. In addition, the relative protein expression levels were detected by Western blot, and we observed that TRX could inhibit the migration and invasion of MDA-MB-231 cells via the ERK/Slug axis. Moreover, an ERK activator (tert-butylhydroquinone, tBHQ) partially reversed the suppressive effect of TRX on MDA-MB-231 cells. 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one</jtitle><date>2023-09-26</date><risdate>2023</risdate><volume>18</volume><issue>9</issue><spage>e0291693</spage><epage>e0291693</epage><pages>e0291693-e0291693</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>As one of the triterpene extracts of Taraxacum, a traditional Chinese plant, taraxerol (TRX) exhibits antitumor activity. In this study, we evaluated the effects of TRX on the migration and invasion of MDA-MB-231 cells, analyzed the molecular mechanism through network pharmacology and molecular docking, and finally verified it by in vitro experiments. The results showed that TRX could inhibit the migration and invasion of MDA-MB-231 cells in a time- and concentration-dependent manner, while MAPK3 was the most promising target and could stably combine with TRX. In addition, the relative protein expression levels were detected by Western blot, and we observed that TRX could inhibit the migration and invasion of MDA-MB-231 cells via the ERK/Slug axis. Moreover, an ERK activator (tert-butylhydroquinone, tBHQ) partially reversed the suppressive effect of TRX on MDA-MB-231 cells. In conclusion, TRX inhibited the migration and invasion of MDA-MB-231 cells via the ERK/Slug axis.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>37751436</pmid><doi>10.1371/journal.pone.0291693</doi><tpages>e0291693</tpages><orcidid>https://orcid.org/0000-0002-4302-389X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Anticancer properties Antitumor activity Bioinformatics Biology and Life Sciences Breast cancer Cancer cells Cancer therapies Care and treatment Cell adhesion & migration Cell growth Diagnosis Health aspects Ligands Medical prognosis Medical research Medicine and Health Sciences Metastasis Molecular docking Molecular modelling Pharmacology Physical Sciences Proteins Research and Analysis Methods Software Statistical analysis t-Butylhydroquinone Wound healing |
| title | Suppression of migration and invasion by taraxerol in the triple-negative breast cancer cell line MDA-MB-231 via the ERK/Slug axis |
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