Durability of the deltamethrin-treated polypropylene long-lasting net LifeNet® in a pyrethroid resistance area in south western Benin: A phase III trial
Background Long-lasting insecticidal bed nets (LLINs) are a key measure for preventing malaria and their evaluation is coordinated by the World Health Organization Pesticide Evaluation Scheme (WHOPES). LifeNet® was granted WHOPES time-limited interim recommendation in 2011 after successful Phase I a...
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| Veröffentlicht in: | PloS one 2023-09, Vol.18 (9), p.e0291755-e0291755 |
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| creator | Djènontin, Armel Alfa, Daleb Bouraima, Aziz Soares, Christophe Dahounto, Amal Cornélie, Sylvie Egrot, Marc Damien, Georgia Remoué, Franck Sagna, André Barembaye Moiroux, Nicolas Pennetier, Cédric |
| description | Background Long-lasting insecticidal bed nets (LLINs) are a key measure for preventing malaria and their evaluation is coordinated by the World Health Organization Pesticide Evaluation Scheme (WHOPES). LifeNet® was granted WHOPES time-limited interim recommendation in 2011 after successful Phase I and Phase II evaluations. Here, we evaluated the durability and community acceptance of LifeNet® in a Phase III trial from June 2014 to June 2017 in Benin rural area. Methods A prospective longitudinal, cluster-randomized, controlled trial with households as the unit of observation was designed to assess the performance of LifeNet® over a three-year period, using a WHOPES fully recommended LLIN (PermaNet® 2.0) as a positive control. The primary outcomes were the bioassay performance using WHO cone assays and tunnel tests, the insecticide content and physical integrity. Results At baseline, 100% of LLINs were within the tolerance limits of their target deltamethrin concentrations. By 36 months only 17.3% of LifeNet® and 8.5% of PermaNet® LLINs still were within their target deltamethrin concentrations. Despite these low rates, 100% of both LLINs meet WHO efficacy criteria (≥ 80% mortality or ≥ 95% knockdown or tunnel test criteria of ≥ 80% mortality or ≥ 90% blood-feeding inhibition) after 36 months using WHO cone bio-assays and tunnel tests. The proportion of LLINs in good physical condition was 33% for LifeNet® and 29% for PermaNet® after 36 months. After 36 M the survivorship was 21% and 26% for LifeNet® and PermaNet® respectively. Although both LLINs were well accepted by the population, complaints of side effects were significantly higher among LifeNet® users than PermaNet® ones. Conclusion LifeNet® LLINs did meet WHO criteria for bio-efficacy throughout the study period and were well accepted by the population. This is an important step towards getting a full WHO recommendation for use in malaria endemic countries. |
| doi_str_mv | 10.1371/journal.pone.0291755 |
| format | Article |
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LifeNet® was granted WHOPES time-limited interim recommendation in 2011 after successful Phase I and Phase II evaluations. Here, we evaluated the durability and community acceptance of LifeNet® in a Phase III trial from June 2014 to June 2017 in Benin rural area. Methods A prospective longitudinal, cluster-randomized, controlled trial with households as the unit of observation was designed to assess the performance of LifeNet® over a three-year period, using a WHOPES fully recommended LLIN (PermaNet® 2.0) as a positive control. The primary outcomes were the bioassay performance using WHO cone assays and tunnel tests, the insecticide content and physical integrity. Results At baseline, 100% of LLINs were within the tolerance limits of their target deltamethrin concentrations. By 36 months only 17.3% of LifeNet® and 8.5% of PermaNet® LLINs still were within their target deltamethrin concentrations. Despite these low rates, 100% of both LLINs meet WHO efficacy criteria (≥ 80% mortality or ≥ 95% knockdown or tunnel test criteria of ≥ 80% mortality or ≥ 90% blood-feeding inhibition) after 36 months using WHO cone bio-assays and tunnel tests. The proportion of LLINs in good physical condition was 33% for LifeNet® and 29% for PermaNet® after 36 months. After 36 M the survivorship was 21% and 26% for LifeNet® and PermaNet® respectively. Although both LLINs were well accepted by the population, complaints of side effects were significantly higher among LifeNet® users than PermaNet® ones. Conclusion LifeNet® LLINs did meet WHO criteria for bio-efficacy throughout the study period and were well accepted by the population. This is an important step towards getting a full WHO recommendation for use in malaria endemic countries.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0291755</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Bioassays ; Biology and Life Sciences ; Censuses ; Clinical trials ; Collaboration ; Communication ; Community ; Criteria ; Deltamethrin ; Durability ; Effectiveness ; Global positioning systems ; GPS ; Households ; Human health and pathology ; Infectious diseases ; Insecticide resistance ; Insecticides ; Life Sciences ; Longitudinal studies ; Malaria ; Medicine and Health Sciences ; Mortality ; Performance assessment ; Pesticides ; Physical Sciences ; Polyethylene ; Polypropylene ; Pyrethroids ; Questionnaires ; Rural areas ; Santé publique et épidémiologie ; Seasons ; Side effects ; Sociodemographics ; Survival ; Tunnels ; Vector-borne diseases</subject><ispartof>PloS one, 2023-09, Vol.18 (9), p.e0291755-e0291755</ispartof><rights>2023 Djènontin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2023 Djènontin et al 2023 Djènontin et al</rights><rights>2023 Djènontin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-21df070dc3413662447b2a1e51235b6c49dfc564bdc9788f574b6e6b98f25b353</citedby><cites>FETCH-LOGICAL-c538t-21df070dc3413662447b2a1e51235b6c49dfc564bdc9788f574b6e6b98f25b353</cites><orcidid>0009-0003-4355-2796 ; 0000-0002-3871-280X ; 0000-0001-8586-792X ; 0000-0002-3362-6371 ; 0000-0003-3662-1450 ; 0000-0001-6755-6167 ; 0000-0003-3220-5660</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511067/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511067/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://hal.science/hal-04213088$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Djènontin, Armel</creatorcontrib><creatorcontrib>Alfa, Daleb</creatorcontrib><creatorcontrib>Bouraima, Aziz</creatorcontrib><creatorcontrib>Soares, Christophe</creatorcontrib><creatorcontrib>Dahounto, Amal</creatorcontrib><creatorcontrib>Cornélie, Sylvie</creatorcontrib><creatorcontrib>Egrot, Marc</creatorcontrib><creatorcontrib>Damien, Georgia</creatorcontrib><creatorcontrib>Remoué, Franck</creatorcontrib><creatorcontrib>Sagna, André Barembaye</creatorcontrib><creatorcontrib>Moiroux, Nicolas</creatorcontrib><creatorcontrib>Pennetier, Cédric</creatorcontrib><title>Durability of the deltamethrin-treated polypropylene long-lasting net LifeNet® in a pyrethroid resistance area in south western Benin: A phase III trial</title><title>PloS one</title><description>Background Long-lasting insecticidal bed nets (LLINs) are a key measure for preventing malaria and their evaluation is coordinated by the World Health Organization Pesticide Evaluation Scheme (WHOPES). LifeNet® was granted WHOPES time-limited interim recommendation in 2011 after successful Phase I and Phase II evaluations. Here, we evaluated the durability and community acceptance of LifeNet® in a Phase III trial from June 2014 to June 2017 in Benin rural area. Methods A prospective longitudinal, cluster-randomized, controlled trial with households as the unit of observation was designed to assess the performance of LifeNet® over a three-year period, using a WHOPES fully recommended LLIN (PermaNet® 2.0) as a positive control. The primary outcomes were the bioassay performance using WHO cone assays and tunnel tests, the insecticide content and physical integrity. Results At baseline, 100% of LLINs were within the tolerance limits of their target deltamethrin concentrations. By 36 months only 17.3% of LifeNet® and 8.5% of PermaNet® LLINs still were within their target deltamethrin concentrations. Despite these low rates, 100% of both LLINs meet WHO efficacy criteria (≥ 80% mortality or ≥ 95% knockdown or tunnel test criteria of ≥ 80% mortality or ≥ 90% blood-feeding inhibition) after 36 months using WHO cone bio-assays and tunnel tests. The proportion of LLINs in good physical condition was 33% for LifeNet® and 29% for PermaNet® after 36 months. After 36 M the survivorship was 21% and 26% for LifeNet® and PermaNet® respectively. Although both LLINs were well accepted by the population, complaints of side effects were significantly higher among LifeNet® users than PermaNet® ones. Conclusion LifeNet® LLINs did meet WHO criteria for bio-efficacy throughout the study period and were well accepted by the population. This is an important step towards getting a full WHO recommendation for use in malaria endemic countries.</description><subject>Bioassays</subject><subject>Biology and Life Sciences</subject><subject>Censuses</subject><subject>Clinical trials</subject><subject>Collaboration</subject><subject>Communication</subject><subject>Community</subject><subject>Criteria</subject><subject>Deltamethrin</subject><subject>Durability</subject><subject>Effectiveness</subject><subject>Global positioning systems</subject><subject>GPS</subject><subject>Households</subject><subject>Human health and pathology</subject><subject>Infectious diseases</subject><subject>Insecticide resistance</subject><subject>Insecticides</subject><subject>Life Sciences</subject><subject>Longitudinal studies</subject><subject>Malaria</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Performance assessment</subject><subject>Pesticides</subject><subject>Physical 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of the deltamethrin-treated polypropylene long-lasting net LifeNet® in a pyrethroid resistance area in south western Benin: A phase III trial</title><author>Djènontin, Armel ; Alfa, Daleb ; Bouraima, Aziz ; Soares, Christophe ; Dahounto, Amal ; Cornélie, Sylvie ; Egrot, Marc ; Damien, Georgia ; Remoué, Franck ; Sagna, André Barembaye ; Moiroux, Nicolas ; Pennetier, Cédric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-21df070dc3413662447b2a1e51235b6c49dfc564bdc9788f574b6e6b98f25b353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bioassays</topic><topic>Biology and Life Sciences</topic><topic>Censuses</topic><topic>Clinical trials</topic><topic>Collaboration</topic><topic>Communication</topic><topic>Community</topic><topic>Criteria</topic><topic>Deltamethrin</topic><topic>Durability</topic><topic>Effectiveness</topic><topic>Global positioning systems</topic><topic>GPS</topic><topic>Households</topic><topic>Human health and pathology</topic><topic>Infectious diseases</topic><topic>Insecticide resistance</topic><topic>Insecticides</topic><topic>Life Sciences</topic><topic>Longitudinal studies</topic><topic>Malaria</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Performance assessment</topic><topic>Pesticides</topic><topic>Physical Sciences</topic><topic>Polyethylene</topic><topic>Polypropylene</topic><topic>Pyrethroids</topic><topic>Questionnaires</topic><topic>Rural areas</topic><topic>Santé publique et épidémiologie</topic><topic>Seasons</topic><topic>Side effects</topic><topic>Sociodemographics</topic><topic>Survival</topic><topic>Tunnels</topic><topic>Vector-borne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Djènontin, Armel</creatorcontrib><creatorcontrib>Alfa, Daleb</creatorcontrib><creatorcontrib>Bouraima, 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Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Djènontin, Armel</au><au>Alfa, Daleb</au><au>Bouraima, Aziz</au><au>Soares, Christophe</au><au>Dahounto, Amal</au><au>Cornélie, Sylvie</au><au>Egrot, Marc</au><au>Damien, Georgia</au><au>Remoué, Franck</au><au>Sagna, André Barembaye</au><au>Moiroux, Nicolas</au><au>Pennetier, Cédric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Durability of the deltamethrin-treated polypropylene long-lasting net LifeNet® in a pyrethroid resistance area in south western Benin: A phase III trial</atitle><jtitle>PloS one</jtitle><date>2023-09-20</date><risdate>2023</risdate><volume>18</volume><issue>9</issue><spage>e0291755</spage><epage>e0291755</epage><pages>e0291755-e0291755</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Background Long-lasting insecticidal bed nets (LLINs) are a key measure for preventing malaria and their evaluation is coordinated by the World Health Organization Pesticide Evaluation Scheme (WHOPES). LifeNet® was granted WHOPES time-limited interim recommendation in 2011 after successful Phase I and Phase II evaluations. Here, we evaluated the durability and community acceptance of LifeNet® in a Phase III trial from June 2014 to June 2017 in Benin rural area. Methods A prospective longitudinal, cluster-randomized, controlled trial with households as the unit of observation was designed to assess the performance of LifeNet® over a three-year period, using a WHOPES fully recommended LLIN (PermaNet® 2.0) as a positive control. The primary outcomes were the bioassay performance using WHO cone assays and tunnel tests, the insecticide content and physical integrity. Results At baseline, 100% of LLINs were within the tolerance limits of their target deltamethrin concentrations. By 36 months only 17.3% of LifeNet® and 8.5% of PermaNet® LLINs still were within their target deltamethrin concentrations. Despite these low rates, 100% of both LLINs meet WHO efficacy criteria (≥ 80% mortality or ≥ 95% knockdown or tunnel test criteria of ≥ 80% mortality or ≥ 90% blood-feeding inhibition) after 36 months using WHO cone bio-assays and tunnel tests. The proportion of LLINs in good physical condition was 33% for LifeNet® and 29% for PermaNet® after 36 months. After 36 M the survivorship was 21% and 26% for LifeNet® and PermaNet® respectively. Although both LLINs were well accepted by the population, complaints of side effects were significantly higher among LifeNet® users than PermaNet® ones. Conclusion LifeNet® LLINs did meet WHO criteria for bio-efficacy throughout the study period and were well accepted by the population. This is an important step towards getting a full WHO recommendation for use in malaria endemic countries.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0291755</doi><orcidid>https://orcid.org/0009-0003-4355-2796</orcidid><orcidid>https://orcid.org/0000-0002-3871-280X</orcidid><orcidid>https://orcid.org/0000-0001-8586-792X</orcidid><orcidid>https://orcid.org/0000-0002-3362-6371</orcidid><orcidid>https://orcid.org/0000-0003-3662-1450</orcidid><orcidid>https://orcid.org/0000-0001-6755-6167</orcidid><orcidid>https://orcid.org/0000-0003-3220-5660</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-09, Vol.18 (9), p.e0291755-e0291755 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2866750133 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Bioassays Biology and Life Sciences Censuses Clinical trials Collaboration Communication Community Criteria Deltamethrin Durability Effectiveness Global positioning systems GPS Households Human health and pathology Infectious diseases Insecticide resistance Insecticides Life Sciences Longitudinal studies Malaria Medicine and Health Sciences Mortality Performance assessment Pesticides Physical Sciences Polyethylene Polypropylene Pyrethroids Questionnaires Rural areas Santé publique et épidémiologie Seasons Side effects Sociodemographics Survival Tunnels Vector-borne diseases |
| title | Durability of the deltamethrin-treated polypropylene long-lasting net LifeNet® in a pyrethroid resistance area in south western Benin: A phase III trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T19%3A39%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Durability%20of%20the%20deltamethrin-treated%20polypropylene%20long-lasting%20net%20LifeNet%C2%AE%20in%20a%20pyrethroid%20resistance%20area%20in%20south%20western%20Benin:%20A%20phase%20III%20trial&rft.jtitle=PloS%20one&rft.au=Dj%C3%A8nontin,%20Armel&rft.date=2023-09-20&rft.volume=18&rft.issue=9&rft.spage=e0291755&rft.epage=e0291755&rft.pages=e0291755-e0291755&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0291755&rft_dat=%3Cproquest_plos_%3E2867152581%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2866750133&rft_id=info:pmid/&rft_doaj_id=oai_doaj_org_article_573de124e1104ce085cb1073f28e3577&rfr_iscdi=true |