Multi-ancestry GWAS analysis identifies two novel loci associated with diabetic eye disease and highlights APOL1 as a high risk locus in patients with diabetic macular edema

Diabetic retinopathy (DR) is a common complication of diabetes. Approximately 20% of DR patients have diabetic macular edema (DME) characterized by fluid leakage into the retina. There is a genetic component to DR and DME risk, but few replicable loci. Because not all DR cases have DME, we focused o...

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Veröffentlicht in:	PLoS genetics 2023-08, Vol.19 (8), p.e1010609-e1010609
Hauptverfasser:	Stockwell, Amy D, Chang, Michael C, Mahajan, Anubha, Forrest, William, Anegondi, Neha, Pendergrass, Rion K, Selvaraj, Suresh, Reeder, Jens, Wei, Eric, Iglesias, Victor A, Creps, Natalie M, Macri, Laura, Neeranjan, Andrea N, van der Brug, Marcel P, Scales, Suzie J, McCarthy, Mark I, Yaspan, Brian L
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Asthma Biology and Life Sciences Biotechnology industry Care and treatment Clinical trials Diabetes Diabetes mellitus Diabetic retinopathy Dropsy Drug dosages Edema Endothelium Eye diseases Genetic aspects Genetic testing Genome-wide association studies Genomes Genotype & phenotype Health risk assessment Identification and classification Medicine and Health Sciences Patients People and Places Quality control Quantitative trait loci Retinopathy Risk factors Sensitivity analysis Software
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