Duration and dosing of systemic corticosteroids for acute exacerbation of COPD, protocol for a systematic review with meta-analysis of randomized trials and cohort studies
Purpose Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a leading cause of deterioration in patients with otherwise stably controlled COPD. Treatments of AECOPD often require the use of corticosteroid therapy in conjunction with bronchodilators and antibiotics. However, the d...
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| creator | Yin, Raymond Wang, Yiyang Ying, Yue Ding, Mutian Ouyang, Yunqing Yuan, Emily Ye, Daniel Yuan, Shirley Li, Guanying Hou, Winston |
| description | Purpose Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a leading cause of deterioration in patients with otherwise stably controlled COPD. Treatments of AECOPD often require the use of corticosteroid therapy in conjunction with bronchodilators and antibiotics. However, the duration and dosage of corticosteroids still remain unclear. We propose to perform this systematic review and meta-analysis of all available randomized control trials (RCTs) and observational cohort studies to comprehensively assess the efficacy and safety of different corticosteroid duration and dosing regimen in the current body of evidence. Methods We will search MEDLINE, EMBASE, CENTRAL via Ovid as well as CINAHL and Web of Science for available literature comparing different corticosteroid duration and dosage in the treatment of AECOPD. We will perform title and full text screening in duplicate, then extract relevant data using a pre-piloted extraction form. We will define short duration as less than 14-day duration of treatment and long duration as greater than 14-day treatment. We will report mortality difference as our primary outcome, with additional comparisons in incidence of re-exacerbation, hospital length of stay, lung function, incidence of hyperglycemia and infection. We will perform risk of bias assessment using the ROB2.0 and ROBINS-I tool, as well as the GRADE assessment to assess the quality of evidence. Results We will publish the full results of our systematic review and meta-analysis in a peer-reviewed journal. Discussions To our knowledge, this represents an updated and most comprehensive review of the literature comparing different duration and dosing regimen of corticosteroid treatments in AECOPD, as we will include both RCTs and observational studies without date or language restrictions. We aim to validate prior meta-analyses and study findings on the efficacy of short duration corticosteroid therapy over longer treatments and to inform future research directions in dosing regimens. |
| doi_str_mv | 10.1371/journal.pone.0290982 |
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Treatments of AECOPD often require the use of corticosteroid therapy in conjunction with bronchodilators and antibiotics. However, the duration and dosage of corticosteroids still remain unclear. We propose to perform this systematic review and meta-analysis of all available randomized control trials (RCTs) and observational cohort studies to comprehensively assess the efficacy and safety of different corticosteroid duration and dosing regimen in the current body of evidence. Methods We will search MEDLINE, EMBASE, CENTRAL via Ovid as well as CINAHL and Web of Science for available literature comparing different corticosteroid duration and dosage in the treatment of AECOPD. We will perform title and full text screening in duplicate, then extract relevant data using a pre-piloted extraction form. We will define short duration as less than 14-day duration of treatment and long duration as greater than 14-day treatment. We will report mortality difference as our primary outcome, with additional comparisons in incidence of re-exacerbation, hospital length of stay, lung function, incidence of hyperglycemia and infection. We will perform risk of bias assessment using the ROB2.0 and ROBINS-I tool, as well as the GRADE assessment to assess the quality of evidence. Results We will publish the full results of our systematic review and meta-analysis in a peer-reviewed journal. Discussions To our knowledge, this represents an updated and most comprehensive review of the literature comparing different duration and dosing regimen of corticosteroid treatments in AECOPD, as we will include both RCTs and observational studies without date or language restrictions. We aim to validate prior meta-analyses and study findings on the efficacy of short duration corticosteroid therapy over longer treatments and to inform future research directions in dosing regimens.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0290982</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Analysis ; Antibiotics ; Bias ; Bibliometrics ; Bronchodilators ; Chronic obstructive pulmonary disease ; Clinical trials ; Cohort analysis ; Corticoids ; Corticosteroids ; Data collection ; Diabetes ; Digital Object Identifier ; Dosage ; Dosage and administration ; Drug therapy ; Dyspnea ; Effectiveness ; Health risks ; Health services ; Hyperglycemia ; Hypertension ; Intervention ; Length of stay ; Literature reviews ; Lung diseases ; Lung diseases, Obstructive ; Medicine and Health Sciences ; Meta-analysis ; Mortality ; Observational studies ; Obstructive lung disease ; Patient outcomes ; Physical Sciences ; Quality assessment ; Registration ; Research and Analysis Methods ; Respiratory agents ; Respiratory function ; Steroids ; Study Protocol ; Systematic review</subject><ispartof>PloS one, 2023-08, Vol.18 (8), p.e0290982-e0290982</ispartof><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Yin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Yin et al 2023 Yin et al</rights><rights>2023 Yin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c619t-82897fca12895c1e055064030f7e26ce5451679141bffabce170082080d670e23</cites><orcidid>0009-0004-5009-8402 ; 0000-0002-1164-1909</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470871/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470871/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids></links><search><contributor>Heo, Jung Yeon</contributor><creatorcontrib>Yin, Raymond</creatorcontrib><creatorcontrib>Wang, Yiyang</creatorcontrib><creatorcontrib>Ying, Yue</creatorcontrib><creatorcontrib>Ding, Mutian</creatorcontrib><creatorcontrib>Ouyang, Yunqing</creatorcontrib><creatorcontrib>Yuan, Emily</creatorcontrib><creatorcontrib>Ye, Daniel</creatorcontrib><creatorcontrib>Yuan, Shirley</creatorcontrib><creatorcontrib>Li, Guanying</creatorcontrib><creatorcontrib>Hou, Winston</creatorcontrib><title>Duration and dosing of systemic corticosteroids for acute exacerbation of COPD, protocol for a systematic review with meta-analysis of randomized trials and cohort studies</title><title>PloS one</title><description>Purpose Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a leading cause of deterioration in patients with otherwise stably controlled COPD. Treatments of AECOPD often require the use of corticosteroid therapy in conjunction with bronchodilators and antibiotics. However, the duration and dosage of corticosteroids still remain unclear. We propose to perform this systematic review and meta-analysis of all available randomized control trials (RCTs) and observational cohort studies to comprehensively assess the efficacy and safety of different corticosteroid duration and dosing regimen in the current body of evidence. Methods We will search MEDLINE, EMBASE, CENTRAL via Ovid as well as CINAHL and Web of Science for available literature comparing different corticosteroid duration and dosage in the treatment of AECOPD. We will perform title and full text screening in duplicate, then extract relevant data using a pre-piloted extraction form. We will define short duration as less than 14-day duration of treatment and long duration as greater than 14-day treatment. We will report mortality difference as our primary outcome, with additional comparisons in incidence of re-exacerbation, hospital length of stay, lung function, incidence of hyperglycemia and infection. We will perform risk of bias assessment using the ROB2.0 and ROBINS-I tool, as well as the GRADE assessment to assess the quality of evidence. Results We will publish the full results of our systematic review and meta-analysis in a peer-reviewed journal. Discussions To our knowledge, this represents an updated and most comprehensive review of the literature comparing different duration and dosing regimen of corticosteroid treatments in AECOPD, as we will include both RCTs and observational studies without date or language restrictions. 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and dosing of systemic corticosteroids for acute exacerbation of COPD, protocol for a systematic review with meta-analysis of randomized trials and cohort studies</title><author>Yin, Raymond ; Wang, Yiyang ; Ying, Yue ; Ding, Mutian ; Ouyang, Yunqing ; Yuan, Emily ; Ye, Daniel ; Yuan, Shirley ; Li, Guanying ; Hou, Winston</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c619t-82897fca12895c1e055064030f7e26ce5451679141bffabce170082080d670e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>Antibiotics</topic><topic>Bias</topic><topic>Bibliometrics</topic><topic>Bronchodilators</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical trials</topic><topic>Cohort analysis</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Data collection</topic><topic>Diabetes</topic><topic>Digital Object 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Raymond</au><au>Wang, Yiyang</au><au>Ying, Yue</au><au>Ding, Mutian</au><au>Ouyang, Yunqing</au><au>Yuan, Emily</au><au>Ye, Daniel</au><au>Yuan, Shirley</au><au>Li, Guanying</au><au>Hou, Winston</au><au>Heo, Jung Yeon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duration and dosing of systemic corticosteroids for acute exacerbation of COPD, protocol for a systematic review with meta-analysis of randomized trials and cohort studies</atitle><jtitle>PloS one</jtitle><date>2023-08-31</date><risdate>2023</risdate><volume>18</volume><issue>8</issue><spage>e0290982</spage><epage>e0290982</epage><pages>e0290982-e0290982</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Purpose Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a leading cause of deterioration in patients with otherwise stably controlled COPD. Treatments of AECOPD often require the use of corticosteroid therapy in conjunction with bronchodilators and antibiotics. However, the duration and dosage of corticosteroids still remain unclear. We propose to perform this systematic review and meta-analysis of all available randomized control trials (RCTs) and observational cohort studies to comprehensively assess the efficacy and safety of different corticosteroid duration and dosing regimen in the current body of evidence. Methods We will search MEDLINE, EMBASE, CENTRAL via Ovid as well as CINAHL and Web of Science for available literature comparing different corticosteroid duration and dosage in the treatment of AECOPD. We will perform title and full text screening in duplicate, then extract relevant data using a pre-piloted extraction form. We will define short duration as less than 14-day duration of treatment and long duration as greater than 14-day treatment. We will report mortality difference as our primary outcome, with additional comparisons in incidence of re-exacerbation, hospital length of stay, lung function, incidence of hyperglycemia and infection. We will perform risk of bias assessment using the ROB2.0 and ROBINS-I tool, as well as the GRADE assessment to assess the quality of evidence. Results We will publish the full results of our systematic review and meta-analysis in a peer-reviewed journal. Discussions To our knowledge, this represents an updated and most comprehensive review of the literature comparing different duration and dosing regimen of corticosteroid treatments in AECOPD, as we will include both RCTs and observational studies without date or language restrictions. We aim to validate prior meta-analyses and study findings on the efficacy of short duration corticosteroid therapy over longer treatments and to inform future research directions in dosing regimens.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0290982</doi><tpages>e0290982</tpages><orcidid>https://orcid.org/0009-0004-5009-8402</orcidid><orcidid>https://orcid.org/0000-0002-1164-1909</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Antibiotics Bias Bibliometrics Bronchodilators Chronic obstructive pulmonary disease Clinical trials Cohort analysis Corticoids Corticosteroids Data collection Diabetes Digital Object Identifier Dosage Dosage and administration Drug therapy Dyspnea Effectiveness Health risks Health services Hyperglycemia Hypertension Intervention Length of stay Literature reviews Lung diseases Lung diseases, Obstructive Medicine and Health Sciences Meta-analysis Mortality Observational studies Obstructive lung disease Patient outcomes Physical Sciences Quality assessment Registration Research and Analysis Methods Respiratory agents Respiratory function Steroids Study Protocol Systematic review |
| title | Duration and dosing of systemic corticosteroids for acute exacerbation of COPD, protocol for a systematic review with meta-analysis of randomized trials and cohort studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T23%3A32%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Duration%20and%20dosing%20of%20systemic%20corticosteroids%20for%20acute%20exacerbation%20of%20COPD,%20protocol%20for%20a%20systematic%20review%20with%20meta-analysis%20of%20randomized%20trials%20and%20cohort%20studies&rft.jtitle=PloS%20one&rft.au=Yin,%20Raymond&rft.date=2023-08-31&rft.volume=18&rft.issue=8&rft.spage=e0290982&rft.epage=e0290982&rft.pages=e0290982-e0290982&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0290982&rft_dat=%3Cgale_plos_%3EA762899214%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2859587694&rft_id=info:pmid/&rft_galeid=A762899214&rft_doaj_id=oai_doaj_org_article_2f543154dc184ae0bdd519b8b43129c4&rfr_iscdi=true |