Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy
Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are...
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| creator | Yatani, Atsuhiko Katsurada, Naoko Fukui, Takafumi Yamada, Jun Satoh, Hiroki Mimura, Chihiro Hazama, Daisuke Yamamoto, Masatsugu Jimbo, Naoe Tanaka, Tomonori Tachihara, Motoko |
| description | Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p |
| doi_str_mv | 10.1371/journal.pone.0290609 |
| format | Article |
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However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0290609</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Biology and Life Sciences ; Biopsy ; Bronchoscopy ; Cancer cells ; Care and treatment ; Comparative analysis ; Complications and side effects ; Diagnosis ; Diagnostic imaging ; Evaluation ; Health aspects ; Japan ; Lesions ; Lung cancer ; Lung cancer, Non-small cell ; Lung diseases ; Medical diagnosis ; Medical instruments ; Medical records ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Mortality ; Non-small cell lung carcinoma ; Patient outcomes ; Patients ; Sheaths ; Small cell lung carcinoma ; Tomography ; Tumor cells ; Tumors ; Variables</subject><ispartof>PloS one, 2023-08, Vol.18 (8), p.e0290609-e0290609</ispartof><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Yatani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Yatani et al 2023 Yatani et al</rights><rights>2023 Yatani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c663t-bd4867bb802f22c65bad308b057230b6edb9a8192beec0765a4d933034a8e7233</cites><orcidid>0000-0002-4598-220X ; 0000-0003-0759-1280 ; 0009-0004-3111-0306 ; 0000-0003-0596-555X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449145/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449145/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids></links><search><contributor>Yamaguchi, Fumihiro</contributor><creatorcontrib>Yatani, Atsuhiko</creatorcontrib><creatorcontrib>Katsurada, Naoko</creatorcontrib><creatorcontrib>Fukui, Takafumi</creatorcontrib><creatorcontrib>Yamada, Jun</creatorcontrib><creatorcontrib>Satoh, Hiroki</creatorcontrib><creatorcontrib>Mimura, Chihiro</creatorcontrib><creatorcontrib>Hazama, Daisuke</creatorcontrib><creatorcontrib>Yamamoto, Masatsugu</creatorcontrib><creatorcontrib>Jimbo, Naoe</creatorcontrib><creatorcontrib>Tanaka, Tomonori</creatorcontrib><creatorcontrib>Tachihara, Motoko</creatorcontrib><title>Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy</title><title>PloS one</title><description>Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope.</description><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Bronchoscopy</subject><subject>Cancer cells</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Diagnostic imaging</subject><subject>Evaluation</subject><subject>Health aspects</subject><subject>Japan</subject><subject>Lesions</subject><subject>Lung cancer</subject><subject>Lung cancer, Non-small cell</subject><subject>Lung diseases</subject><subject>Medical diagnosis</subject><subject>Medical instruments</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Non-small cell lung 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Daisuke</au><au>Yamamoto, Masatsugu</au><au>Jimbo, Naoe</au><au>Tanaka, Tomonori</au><au>Tachihara, Motoko</au><au>Yamaguchi, Fumihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy</atitle><jtitle>PloS one</jtitle><date>2023-08-24</date><risdate>2023</risdate><volume>18</volume><issue>8</issue><spage>e0290609</spage><epage>e0290609</epage><pages>e0290609-e0290609</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0290609</doi><tpages>e0290609</tpages><orcidid>https://orcid.org/0000-0002-4598-220X</orcidid><orcidid>https://orcid.org/0000-0003-0759-1280</orcidid><orcidid>https://orcid.org/0009-0004-3111-0306</orcidid><orcidid>https://orcid.org/0000-0003-0596-555X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Biopsy Bronchoscopy Cancer cells Care and treatment Comparative analysis Complications and side effects Diagnosis Diagnostic imaging Evaluation Health aspects Japan Lesions Lung cancer Lung cancer, Non-small cell Lung diseases Medical diagnosis Medical instruments Medical records Medical research Medicine and Health Sciences Medicine, Experimental Mortality Non-small cell lung carcinoma Patient outcomes Patients Sheaths Small cell lung carcinoma Tomography Tumor cells Tumors Variables |
| title | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T22%3A54%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnostic%20yield%20and%20the%20number%20of%20tumor%20cells%20of%20ultrathin%20bronchoscopy%20for%20peripheral%20lung%20lesions:%20A%20comparison%20with%20thin%20bronchoscopy&rft.jtitle=PloS%20one&rft.au=Yatani,%20Atsuhiko&rft.date=2023-08-24&rft.volume=18&rft.issue=8&rft.spage=e0290609&rft.epage=e0290609&rft.pages=e0290609-e0290609&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0290609&rft_dat=%3Cgale_plos_%3EA762050003%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2856784729&rft_id=info:pmid/&rft_galeid=A762050003&rft_doaj_id=oai_doaj_org_article_9c8a17615002420a8cc76183116b2f2c&rfr_iscdi=true |