Proliferating cell nuclear antigen inhibitors block distinct stages of herpes simplex virus infection

Proliferating cell nuclear antigen (PCNA) forms a homotrimer that encircles replicating DNA and is bound by DNA polymerases to add processivity to cellular DNA synthesis. In addition, PCNA acts as a scaffold to recruit DNA repair and chromatin remodeling proteins to replicating DNA via its interdoma...

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Veröffentlicht in:	PLoS pathogens 2023-07, Vol.19 (7), p.e1011539-e1011539
Hauptverfasser:	Packard, Jessica E, Williams, Maya R, Fromuth, Daniel P, Dembowski, Jill A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Base excision repair Biology and life sciences Cell cycle Chromatin Chromatin remodeling Cytotoxicity Defects Deoxyribonucleic acid Diagnosis DNA DNA biosynthesis DNA polymerase DNA polymerases DNA repair DNA replication DNA synthesis DNA-directed DNA polymerase Experiments Gene expression Genes Genetic aspects Genetic transcription Genomes Health aspects Herpes simplex Herpes simplex virus Herpes viruses Hydrogen bonds Infection Infections Inhibitors Monomers Proliferating cell nuclear antigen Protein interaction Protein-protein interactions Proteins Recruitment Replication Replication forks Research and analysis methods RNA polymerase Synthesis Transcription factors Uracil Viral infections Virus diseases Viruses Yeast
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