A retrospective evaluation of the effect of oclacitinib (Apoquel) administration on development of surgical site infection following clean orthopedic stifle surgery
The aim of this study was to determine the effect of oclacitinib (Apoquel) on development of surgical site infections in canines following clean orthopedic stifle surgery. Medical records of dogs undergoing unilateral, clean orthopedic stifle procedures were retrospectively examined for development...
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| Veröffentlicht in: | PloS one 2023-08, Vol.18 (8), p.e0289827-e0289827 |
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| creator | Motz, Alyssa K St Germaine, Lindsay L Hoffmann, Daniel E Sung, Jed |
| description | The aim of this study was to determine the effect of oclacitinib (Apoquel) on development of surgical site infections in canines following clean orthopedic stifle surgery. Medical records of dogs undergoing unilateral, clean orthopedic stifle procedures were retrospectively examined for development of post-operative surgical site infections. Data collected for statistical analysis included age, sex, body weight, current medications, anesthesia and surgery times, white blood cell count, and neutrophil count. Surgical site infections were identified in 8.7% (34/390) of stifle procedures- 8.0% (29/364) in dogs not treated with oclacitinib and 19.2% (5/26) in dogs treated with oclacitinib (p = 0.053). There was a significant difference in development of surgical site infection in dogs with longer anesthesia times (p = 0.003) and higher body weights (p = 0.037). Dogs being treated with oclacitinib at the time of clean, orthopedic stifle surgery did not have a significantly higher incidence of surgical site infections. However, client education regarding risk of infection and increased patient monitoring post-operatively are recommended, especially in patients with increased body weight or longer anesthetic times. |
| doi_str_mv | 10.1371/journal.pone.0289827 |
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Medical records of dogs undergoing unilateral, clean orthopedic stifle procedures were retrospectively examined for development of post-operative surgical site infections. Data collected for statistical analysis included age, sex, body weight, current medications, anesthesia and surgery times, white blood cell count, and neutrophil count. Surgical site infections were identified in 8.7% (34/390) of stifle procedures- 8.0% (29/364) in dogs not treated with oclacitinib and 19.2% (5/26) in dogs treated with oclacitinib (p = 0.053). There was a significant difference in development of surgical site infection in dogs with longer anesthesia times (p = 0.003) and higher body weights (p = 0.037). Dogs being treated with oclacitinib at the time of clean, orthopedic stifle surgery did not have a significantly higher incidence of surgical site infections. However, client education regarding risk of infection and increased patient monitoring post-operatively are recommended, especially in patients with increased body weight or longer anesthetic times.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0289827</identifier><identifier>PMID: 37556416</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anesthesia ; Antibiotics ; Biology and Life Sciences ; Body weight ; Bone surgery ; Complications ; Dermatitis ; Dogs ; Health aspects ; Health risks ; Leukocytes (neutrophilic) ; Medical records ; Medicine and Health Sciences ; Multivariate analysis ; Orthopedics ; Patients ; Skin ; Statistical analysis ; Surgeons ; Surgery ; Surgical site infections</subject><ispartof>PloS one, 2023-08, Vol.18 (8), p.e0289827-e0289827</ispartof><rights>Copyright: © 2023 Motz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Motz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Motz et al 2023 Motz et al</rights><rights>2023 Motz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Medical records of dogs undergoing unilateral, clean orthopedic stifle procedures were retrospectively examined for development of post-operative surgical site infections. Data collected for statistical analysis included age, sex, body weight, current medications, anesthesia and surgery times, white blood cell count, and neutrophil count. Surgical site infections were identified in 8.7% (34/390) of stifle procedures- 8.0% (29/364) in dogs not treated with oclacitinib and 19.2% (5/26) in dogs treated with oclacitinib (p = 0.053). There was a significant difference in development of surgical site infection in dogs with longer anesthesia times (p = 0.003) and higher body weights (p = 0.037). Dogs being treated with oclacitinib at the time of clean, orthopedic stifle surgery did not have a significantly higher incidence of surgical site infections. However, client education regarding risk of infection and increased patient monitoring post-operatively are recommended, especially in patients with increased body weight or longer anesthetic times.</description><subject>Anesthesia</subject><subject>Antibiotics</subject><subject>Biology and Life Sciences</subject><subject>Body weight</subject><subject>Bone surgery</subject><subject>Complications</subject><subject>Dermatitis</subject><subject>Dogs</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Leukocytes (neutrophilic)</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Multivariate analysis</subject><subject>Orthopedics</subject><subject>Patients</subject><subject>Skin</subject><subject>Statistical analysis</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Surgical site 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Jeenchen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A retrospective evaluation of the effect of oclacitinib (Apoquel) administration on development of surgical site infection following clean orthopedic stifle surgery</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-08-09</date><risdate>2023</risdate><volume>18</volume><issue>8</issue><spage>e0289827</spage><epage>e0289827</epage><pages>e0289827-e0289827</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aim of this study was to determine the effect of oclacitinib (Apoquel) on development of surgical site infections in canines following clean orthopedic stifle surgery. Medical records of dogs undergoing unilateral, clean orthopedic stifle procedures were retrospectively examined for development of post-operative surgical site infections. Data collected for statistical analysis included age, sex, body weight, current medications, anesthesia and surgery times, white blood cell count, and neutrophil count. Surgical site infections were identified in 8.7% (34/390) of stifle procedures- 8.0% (29/364) in dogs not treated with oclacitinib and 19.2% (5/26) in dogs treated with oclacitinib (p = 0.053). There was a significant difference in development of surgical site infection in dogs with longer anesthesia times (p = 0.003) and higher body weights (p = 0.037). Dogs being treated with oclacitinib at the time of clean, orthopedic stifle surgery did not have a significantly higher incidence of surgical site infections. 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| subjects | Anesthesia Antibiotics Biology and Life Sciences Body weight Bone surgery Complications Dermatitis Dogs Health aspects Health risks Leukocytes (neutrophilic) Medical records Medicine and Health Sciences Multivariate analysis Orthopedics Patients Skin Statistical analysis Surgeons Surgery Surgical site infections |
| title | A retrospective evaluation of the effect of oclacitinib (Apoquel) administration on development of surgical site infection following clean orthopedic stifle surgery |
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