Identification of genes critical for inducing ulcerative colitis and exploring their tumorigenic potential in human colorectal carcinoma
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease leading to continuous mucosal inflammation in the rectum extending proximally towards the colon. Chronic and/or recurrent UC is one of the critical predisposing mediators of the oncogenesis of human colorectal carcinoma (CRC)....
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| Veröffentlicht in: | PloS one 2023-08, Vol.18 (8), p.e0289064-e0289064 |
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| creator | Patra, Ritwik Dey, Amit Kumar Mukherjee, Suprabhat |
| description | Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease leading to continuous mucosal inflammation in the rectum extending proximally towards the colon. Chronic and/or recurrent UC is one of the critical predisposing mediators of the oncogenesis of human colorectal carcinoma (CRC). Perturbations of the differential expression of the UC-critical genes exert an intense impact on the neoplastic transformation of the affected tissue(s). Herein, a comprehensive exploration of the UC-critical genes from the transcriptomic profiles of UC patients was conducted to study the differential expression, functional enrichment, genomic alterations, signal transduction pathways, and immune infiltration level encountered by these genes concerning the oncogenesis of CRC. The study reveals that WFDC2, TTLL12, THRA, and EPHB3 play crucial roles as UC-CRC critical genes and are positively correlated with the molecular transformation of UC to CRC. Taken together, these genes can be used as potential biomarkers and therapeutic targets for combating UC-induced human CRC. |
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Chronic and/or recurrent UC is one of the critical predisposing mediators of the oncogenesis of human colorectal carcinoma (CRC). Perturbations of the differential expression of the UC-critical genes exert an intense impact on the neoplastic transformation of the affected tissue(s). Herein, a comprehensive exploration of the UC-critical genes from the transcriptomic profiles of UC patients was conducted to study the differential expression, functional enrichment, genomic alterations, signal transduction pathways, and immune infiltration level encountered by these genes concerning the oncogenesis of CRC. The study reveals that WFDC2, TTLL12, THRA, and EPHB3 play crucial roles as UC-CRC critical genes and are positively correlated with the molecular transformation of UC to CRC. Taken together, these genes can be used as potential biomarkers and therapeutic targets for combating UC-induced human CRC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0289064</identifier><identifier>PMID: 37535606</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Biomarkers ; Colorectal cancer ; Colorectal carcinoma ; Computer and Information Sciences ; Datasets ; Diagnosis ; Epigenetics ; Gene expression ; Genes ; Genetic aspects ; Genetic transformation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Irritable bowel syndrome ; Medicine and Health Sciences ; Metastases ; Mutation ; Pathogenesis ; Pediatrics ; Perturbation ; Proteins ; Risk factors ; Signal transduction ; Therapeutic targets ; Transcriptomics ; Tumor necrosis factor-TNF ; Tumorigenesis ; Ulcerative colitis</subject><ispartof>PloS one, 2023-08, Vol.18 (8), p.e0289064-e0289064</ispartof><rights>Copyright: © 2023 Patra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Patra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Patra et al 2023 Patra et al</rights><rights>2023 Patra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Chronic and/or recurrent UC is one of the critical predisposing mediators of the oncogenesis of human colorectal carcinoma (CRC). Perturbations of the differential expression of the UC-critical genes exert an intense impact on the neoplastic transformation of the affected tissue(s). Herein, a comprehensive exploration of the UC-critical genes from the transcriptomic profiles of UC patients was conducted to study the differential expression, functional enrichment, genomic alterations, signal transduction pathways, and immune infiltration level encountered by these genes concerning the oncogenesis of CRC. The study reveals that WFDC2, TTLL12, THRA, and EPHB3 play crucial roles as UC-CRC critical genes and are positively correlated with the molecular transformation of UC to CRC. 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patra, Ritwik</au><au>Dey, Amit Kumar</au><au>Mukherjee, Suprabhat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of genes critical for inducing ulcerative colitis and exploring their tumorigenic potential in human colorectal carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-08-03</date><risdate>2023</risdate><volume>18</volume><issue>8</issue><spage>e0289064</spage><epage>e0289064</epage><pages>e0289064-e0289064</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease leading to continuous mucosal inflammation in the rectum extending proximally towards the colon. Chronic and/or recurrent UC is one of the critical predisposing mediators of the oncogenesis of human colorectal carcinoma (CRC). Perturbations of the differential expression of the UC-critical genes exert an intense impact on the neoplastic transformation of the affected tissue(s). Herein, a comprehensive exploration of the UC-critical genes from the transcriptomic profiles of UC patients was conducted to study the differential expression, functional enrichment, genomic alterations, signal transduction pathways, and immune infiltration level encountered by these genes concerning the oncogenesis of CRC. The study reveals that WFDC2, TTLL12, THRA, and EPHB3 play crucial roles as UC-CRC critical genes and are positively correlated with the molecular transformation of UC to CRC. 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| subjects | Biology and Life Sciences Biomarkers Colorectal cancer Colorectal carcinoma Computer and Information Sciences Datasets Diagnosis Epigenetics Gene expression Genes Genetic aspects Genetic transformation Inflammatory bowel disease Inflammatory bowel diseases Irritable bowel syndrome Medicine and Health Sciences Metastases Mutation Pathogenesis Pediatrics Perturbation Proteins Risk factors Signal transduction Therapeutic targets Transcriptomics Tumor necrosis factor-TNF Tumorigenesis Ulcerative colitis |
| title | Identification of genes critical for inducing ulcerative colitis and exploring their tumorigenic potential in human colorectal carcinoma |
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