Development of ankylosing spondylitis in patients with ulcerative colitis: A systematic meta-analysis
Ulcerative colitis (UC) is a manifestation of inflammatory bowel disease (IBD), which can cause inflammation of the intestinal tract. Ankylosing spondylitis (AS) is an inflammatory disease of the sacroiliac joints. Many studies have found that some UC patients progress to AS. In this study, we condu...
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| description | Ulcerative colitis (UC) is a manifestation of inflammatory bowel disease (IBD), which can cause inflammation of the intestinal tract. Ankylosing spondylitis (AS) is an inflammatory disease of the sacroiliac joints. Many studies have found that some UC patients progress to AS. In this study, we conducted a literature search and meta-analysis to investigate the prevalence of AS among UC patients during follow-up.
The studies related to the AS among patients with UC were obtained from PubMed, Web of Science, Embase, and Cochrane Library databases since its inception-December 2022. The literature was screened strictly according to inclusion and exclusion criteria. Forest plots were used to detect the overall incidence of AS in UC and to compare the risk ratios for the development of AS in the UC. The heterogeneity of studies was assessed using I2 statistical methods.
1) 17 studies with 98704 UC patients were included. 2)700 UC patients developed AS during follow-up (1.66%, 95% CI: 0.89-2.62%). Human leukocyte antigen B27 (HLA-B27) was reported in 3 studies. HLA-B27 positivity was significantly higher than the incidence of HLA-B27 negativity in AS patients (68.29% vs 31.71%, P < 0.0001). There was significantly increased risk of AS development in HLA-B27 positive IBD patients (RR: 22.17, 95% CI: 11.79-41.66, P < 0.0001). 3)The definite follow-up time was reported in 12 studies (range: 0.3-40 years). After follow-up for ≥5 years, the incidence of AS among patients with UC was 1.75% (95% CI: 0.62-3.37%). Meanwhile, after follow-up for |
| doi_str_mv | 10.1371/journal.pone.0289021 |
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| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2844636256</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A759254655</galeid><sourcerecordid>A759254655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c627t-e2ca3c841b93252240c42baa814c5e0fb15bc4180c402eea929b75fb0bf4a6cf3</originalsourceid><addsrcrecordid>eNqNkttu1DAQhiMEoqXwBggsISG4yOJzEm7QqpwqVarE6dZyvJNdFycOsbOQt8fbptUu6gXyha3xN_-Mx3-WPSV4QVhB3lz6cei0W_S-gwWmZYUpuZcdk4rRXFLM7u-dj7JHIVxiLFgp5cPsiBWCFlTg4wzewxac71voIvIN0t3PyflguzUKSXk1ORttQLZDvY42QQH9tnGDRmdgSJEtIOOvmLdoicIUIrQpbFALUec6NTgFGx5nDxrtAjyZ95Ps-8cP304_5-cXn85Ol-e5kbSIOVCjmSk5qVPjglKODae11iXhRgBuaiJqw0mZwpgC6IpWdSGaGtcN19I07CR7fq3bpzeoeUJB0ZJzySQVMhHvZmKsW1iZ9KJBO9UPttXDpLy26vCmsxu19ltFMKsYESwpvJoVBv9rhBBVa4MB53QHfrwqJggupBQJffEPendLM7XWDpTtGp8Km52oWhaiooJLsdNa3EGltYLWmuSBxqb4QcLrg4TERPgT13oMQZ19_fL_7MWPQ_blHrsB7eImeDdG67twCPJr0Aw-hAGa2ykTrHYWvpmG2llYzRZOac_2f-g26caz7C-HWu3a</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2844636256</pqid></control><display><type>article</type><title>Development of ankylosing spondylitis in patients with ulcerative colitis: A systematic meta-analysis</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Lin, Aitao ; Tan, Yongyi ; Chen, Jinxia ; Liu, Xiaoyu ; Wu, Jinyu</creator><contributor>AbdelMassih, Antoine Fakhry</contributor><creatorcontrib>Lin, Aitao ; Tan, Yongyi ; Chen, Jinxia ; Liu, Xiaoyu ; Wu, Jinyu ; AbdelMassih, Antoine Fakhry</creatorcontrib><description>Ulcerative colitis (UC) is a manifestation of inflammatory bowel disease (IBD), which can cause inflammation of the intestinal tract. Ankylosing spondylitis (AS) is an inflammatory disease of the sacroiliac joints. Many studies have found that some UC patients progress to AS. In this study, we conducted a literature search and meta-analysis to investigate the prevalence of AS among UC patients during follow-up.
The studies related to the AS among patients with UC were obtained from PubMed, Web of Science, Embase, and Cochrane Library databases since its inception-December 2022. The literature was screened strictly according to inclusion and exclusion criteria. Forest plots were used to detect the overall incidence of AS in UC and to compare the risk ratios for the development of AS in the UC. The heterogeneity of studies was assessed using I2 statistical methods.
1) 17 studies with 98704 UC patients were included. 2)700 UC patients developed AS during follow-up (1.66%, 95% CI: 0.89-2.62%). Human leukocyte antigen B27 (HLA-B27) was reported in 3 studies. HLA-B27 positivity was significantly higher than the incidence of HLA-B27 negativity in AS patients (68.29% vs 31.71%, P < 0.0001). There was significantly increased risk of AS development in HLA-B27 positive IBD patients (RR: 22.17, 95% CI: 11.79-41.66, P < 0.0001). 3)The definite follow-up time was reported in 12 studies (range: 0.3-40 years). After follow-up for ≥5 years, the incidence of AS among patients with UC was 1.75% (95% CI: 0.62-3.37%). Meanwhile, after follow-up for <5 years, the incidence of AS among patients with UC was 1.41% (95% CI: 0.65-2.37%) which was significant.
Patients with UC are more likely to develop AS in the future. Furthermore, the IBD patients are at a higher risk of AS who have positive HLA-B27. The incidence of AS increased with longer follow-up time.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0289021</identifier><identifier>PMID: 37527250</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Ankylosing spondylitis ; Antigens ; Arthritis ; Biology and Life Sciences ; Care and treatment ; Cohort analysis ; Complications and side effects ; Cross-sectional studies ; Development and progression ; Diagnosis ; Disease susceptibility ; Health risks ; Heterogeneity ; Histocompatibility antigen HLA ; Histocompatibility antigens ; HLA histocompatibility antigens ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory diseases ; Joint diseases ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Meta-analysis ; Pathogenesis ; Physical Sciences ; Research and Analysis Methods ; Risk ; Software ; Statistical methods ; Ulcerative colitis</subject><ispartof>PloS one, 2023-08, Vol.18 (8), p.e0289021-e0289021</ispartof><rights>Copyright: © 2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Lin et al 2023 Lin et al</rights><rights>2023 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c627t-e2ca3c841b93252240c42baa814c5e0fb15bc4180c402eea929b75fb0bf4a6cf3</citedby><cites>FETCH-LOGICAL-c627t-e2ca3c841b93252240c42baa814c5e0fb15bc4180c402eea929b75fb0bf4a6cf3</cites><orcidid>0009-0002-8711-6956</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393153/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393153/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37527250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>AbdelMassih, Antoine Fakhry</contributor><creatorcontrib>Lin, Aitao</creatorcontrib><creatorcontrib>Tan, Yongyi</creatorcontrib><creatorcontrib>Chen, Jinxia</creatorcontrib><creatorcontrib>Liu, Xiaoyu</creatorcontrib><creatorcontrib>Wu, Jinyu</creatorcontrib><title>Development of ankylosing spondylitis in patients with ulcerative colitis: A systematic meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Ulcerative colitis (UC) is a manifestation of inflammatory bowel disease (IBD), which can cause inflammation of the intestinal tract. Ankylosing spondylitis (AS) is an inflammatory disease of the sacroiliac joints. Many studies have found that some UC patients progress to AS. In this study, we conducted a literature search and meta-analysis to investigate the prevalence of AS among UC patients during follow-up.
The studies related to the AS among patients with UC were obtained from PubMed, Web of Science, Embase, and Cochrane Library databases since its inception-December 2022. The literature was screened strictly according to inclusion and exclusion criteria. Forest plots were used to detect the overall incidence of AS in UC and to compare the risk ratios for the development of AS in the UC. The heterogeneity of studies was assessed using I2 statistical methods.
1) 17 studies with 98704 UC patients were included. 2)700 UC patients developed AS during follow-up (1.66%, 95% CI: 0.89-2.62%). Human leukocyte antigen B27 (HLA-B27) was reported in 3 studies. HLA-B27 positivity was significantly higher than the incidence of HLA-B27 negativity in AS patients (68.29% vs 31.71%, P < 0.0001). There was significantly increased risk of AS development in HLA-B27 positive IBD patients (RR: 22.17, 95% CI: 11.79-41.66, P < 0.0001). 3)The definite follow-up time was reported in 12 studies (range: 0.3-40 years). After follow-up for ≥5 years, the incidence of AS among patients with UC was 1.75% (95% CI: 0.62-3.37%). Meanwhile, after follow-up for <5 years, the incidence of AS among patients with UC was 1.41% (95% CI: 0.65-2.37%) which was significant.
Patients with UC are more likely to develop AS in the future. Furthermore, the IBD patients are at a higher risk of AS who have positive HLA-B27. The incidence of AS increased with longer follow-up time.</description><subject>Analysis</subject><subject>Ankylosing spondylitis</subject><subject>Antigens</subject><subject>Arthritis</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Cohort analysis</subject><subject>Complications and side effects</subject><subject>Cross-sectional studies</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Disease susceptibility</subject><subject>Health risks</subject><subject>Heterogeneity</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility antigens</subject><subject>HLA histocompatibility antigens</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory diseases</subject><subject>Joint diseases</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, Experimental</subject><subject>Meta-analysis</subject><subject>Pathogenesis</subject><subject>Physical Sciences</subject><subject>Research and Analysis Methods</subject><subject>Risk</subject><subject>Software</subject><subject>Statistical methods</subject><subject>Ulcerative 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of ankylosing spondylitis in patients with ulcerative colitis: A systematic meta-analysis</title><author>Lin, Aitao ; Tan, Yongyi ; Chen, Jinxia ; Liu, Xiaoyu ; Wu, Jinyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c627t-e2ca3c841b93252240c42baa814c5e0fb15bc4180c402eea929b75fb0bf4a6cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>Ankylosing spondylitis</topic><topic>Antigens</topic><topic>Arthritis</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Cohort analysis</topic><topic>Complications and side effects</topic><topic>Cross-sectional studies</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Disease susceptibility</topic><topic>Health risks</topic><topic>Heterogeneity</topic><topic>Histocompatibility antigen HLA</topic><topic>Histocompatibility antigens</topic><topic>HLA histocompatibility antigens</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Inflammatory diseases</topic><topic>Joint diseases</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Medicine, Experimental</topic><topic>Meta-analysis</topic><topic>Pathogenesis</topic><topic>Physical Sciences</topic><topic>Research and Analysis Methods</topic><topic>Risk</topic><topic>Software</topic><topic>Statistical methods</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Aitao</creatorcontrib><creatorcontrib>Tan, Yongyi</creatorcontrib><creatorcontrib>Chen, Jinxia</creatorcontrib><creatorcontrib>Liu, Xiaoyu</creatorcontrib><creatorcontrib>Wu, Jinyu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: 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Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Aitao</au><au>Tan, Yongyi</au><au>Chen, Jinxia</au><au>Liu, Xiaoyu</au><au>Wu, Jinyu</au><au>AbdelMassih, Antoine Fakhry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of ankylosing spondylitis in patients with ulcerative colitis: A systematic meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>18</volume><issue>8</issue><spage>e0289021</spage><epage>e0289021</epage><pages>e0289021-e0289021</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Ulcerative colitis (UC) is a manifestation of inflammatory bowel disease (IBD), which can cause inflammation of the intestinal tract. Ankylosing spondylitis (AS) is an inflammatory disease of the sacroiliac joints. Many studies have found that some UC patients progress to AS. In this study, we conducted a literature search and meta-analysis to investigate the prevalence of AS among UC patients during follow-up.
The studies related to the AS among patients with UC were obtained from PubMed, Web of Science, Embase, and Cochrane Library databases since its inception-December 2022. The literature was screened strictly according to inclusion and exclusion criteria. Forest plots were used to detect the overall incidence of AS in UC and to compare the risk ratios for the development of AS in the UC. The heterogeneity of studies was assessed using I2 statistical methods.
1) 17 studies with 98704 UC patients were included. 2)700 UC patients developed AS during follow-up (1.66%, 95% CI: 0.89-2.62%). Human leukocyte antigen B27 (HLA-B27) was reported in 3 studies. HLA-B27 positivity was significantly higher than the incidence of HLA-B27 negativity in AS patients (68.29% vs 31.71%, P < 0.0001). There was significantly increased risk of AS development in HLA-B27 positive IBD patients (RR: 22.17, 95% CI: 11.79-41.66, P < 0.0001). 3)The definite follow-up time was reported in 12 studies (range: 0.3-40 years). After follow-up for ≥5 years, the incidence of AS among patients with UC was 1.75% (95% CI: 0.62-3.37%). Meanwhile, after follow-up for <5 years, the incidence of AS among patients with UC was 1.41% (95% CI: 0.65-2.37%) which was significant.
Patients with UC are more likely to develop AS in the future. Furthermore, the IBD patients are at a higher risk of AS who have positive HLA-B27. The incidence of AS increased with longer follow-up time.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37527250</pmid><doi>10.1371/journal.pone.0289021</doi><tpages>e0289021</tpages><orcidid>https://orcid.org/0009-0002-8711-6956</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Ankylosing spondylitis Antigens Arthritis Biology and Life Sciences Care and treatment Cohort analysis Complications and side effects Cross-sectional studies Development and progression Diagnosis Disease susceptibility Health risks Heterogeneity Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens Inflammatory bowel disease Inflammatory bowel diseases Inflammatory diseases Joint diseases Medical research Medicine and Health Sciences Medicine, Experimental Meta-analysis Pathogenesis Physical Sciences Research and Analysis Methods Risk Software Statistical methods Ulcerative colitis |
| title | Development of ankylosing spondylitis in patients with ulcerative colitis: A systematic meta-analysis |
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