Validation of robust radiobiological optimization algorithms based on the mixed beam model for intensity-modulated carbon-ion therapy

Currently, treatment planning systems (TPSs) that can compute the intensities of intensity-modulated carbon-ion therapy (IMCT) using scanned carbon-ion beams are limited. In the present study, the computational efficacy of the newly designed IMCT algorithms was analyzed for the first time based on t...

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Veröffentlicht in:	PloS one 2023-07, Vol.18 (7), p.e0288545-e0288545
Hauptverfasser:	Yagi, Masashi, Tsubouchi, Toshiro, Hamatani, Noriaki, Takashina, Masaaki, Saruwatari, Naoto, Minami, Kazumasa, Wakisaka, Yushi, Fujitaka, Shinichiro, Hirayama, Shusuke, Nihongi, Hideaki, Hasegawa, Azusa, Koizumi, Masahiko, Shimizu, Shinichi, Ogawa, Kazuhiko, Kanai, Tatsuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Atoms & subatomic particles Biological effects Biology and Life Sciences Cancer Carbon Carbon - therapeutic use Care and treatment Complications and side effects Computer applications Computing costs Heavy Ion Radiotherapy - methods Ion beams Ions Mathematical optimization Medicine and Health Sciences Optimization Optimization algorithms Patient outcomes Physical Sciences Position errors Proton Therapy - methods Radiation Radiation therapy Radiotherapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - methods Relative biological effectiveness (RBE) Research and Analysis Methods Robustness (mathematics) Sensitivity enhancement
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