Survival outcomes of breast cancer patients with recurrence after surgery according to period and subtype
To analyze and compare the survival rates of recurrent breast cancer patients in Korea between two periods (period I: 2000-2007; period II: 2008-2013) and to identify the factors associated with outcomes and changes over time in the duration of survival after recurrence. We retrospectively analyzed...
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| Veröffentlicht in: | PloS one 2023-07, Vol.18 (7), p.e0284460-e0284460 |
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| creator | Lee, Young-Jin Yoo, Tae-Kyung Kim, Jisun Chung, Il Yong Ko, Beom Seok Kim, Hee Jeong Lee, Jong Won Son, Byung Ho Ahn, Sei-Hyun Lee, Sae Byul |
| description | To analyze and compare the survival rates of recurrent breast cancer patients in Korea between two periods (period I: 2000-2007; period II: 2008-2013) and to identify the factors associated with outcomes and changes over time in the duration of survival after recurrence.
We retrospectively analyzed 2,407 patients who had recurrent breast cancer with treated between January 2000 and December 2013 and divided them into two periods according to the year of recurrence. We reviewed the age at diagnosis, clinical manifestations, pathology report, surgical methods, types of adjuvant treatment, type of recurrence, and follow-up period.
The median follow-up was 30.6 months (range, 0-223.4) from the time of relapse, and the median survival time was 42.3 months. Survival after recurrence (SAR) significantly improved from 38.0 months in period I to 49.7 months in period II (p < 0.001). In the analysis performed according to the hormone receptor and HER2 status subtypes, all subtypes except the triple-negative subtype showed higher SAR in period II than period I. Age at diagnosis, tumor stage, and treatment after recurrence were significantly correlated with survival outcomes.
The survival outcomes of Korean patients with breast cancer after the first recurrence have improved in Korea. Such improvements may be attributed to advances in treatment. |
| doi_str_mv | 10.1371/journal.pone.0284460 |
| format | Article |
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We retrospectively analyzed 2,407 patients who had recurrent breast cancer with treated between January 2000 and December 2013 and divided them into two periods according to the year of recurrence. We reviewed the age at diagnosis, clinical manifestations, pathology report, surgical methods, types of adjuvant treatment, type of recurrence, and follow-up period.
The median follow-up was 30.6 months (range, 0-223.4) from the time of relapse, and the median survival time was 42.3 months. Survival after recurrence (SAR) significantly improved from 38.0 months in period I to 49.7 months in period II (p < 0.001). In the analysis performed according to the hormone receptor and HER2 status subtypes, all subtypes except the triple-negative subtype showed higher SAR in period II than period I. Age at diagnosis, tumor stage, and treatment after recurrence were significantly correlated with survival outcomes.
The survival outcomes of Korean patients with breast cancer after the first recurrence have improved in Korea. Such improvements may be attributed to advances in treatment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0284460</identifier><identifier>PMID: 37498831</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Breast cancer ; Breast Neoplasms - pathology ; Cancer patients ; Cancer therapies ; Care and treatment ; Chemotherapy ; Diagnosis ; Disease ; Disease-Free Survival ; Diseases ; ErbB-2 protein ; Ethics ; Female ; Humans ; Korea ; Lymphatic system ; Mammography ; Medical diagnosis ; Medical prognosis ; Medicine and Health Sciences ; Metastasis ; Neoplasm Recurrence, Local - pathology ; Patient outcomes ; Patients ; Prognosis ; Radiation therapy ; Receptor, ErbB-2 ; Receptors, Progesterone ; Regression analysis ; Relapse ; Retrospective Studies ; Surgery ; Survival ; Survival Rate ; Tomography</subject><ispartof>PloS one, 2023-07, Vol.18 (7), p.e0284460-e0284460</ispartof><rights>Copyright: © 2023 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Lee et al 2023 Lee et al</rights><rights>2023 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c576t-3ec613c64dd78f90428e54488f9cde79a575ee9c2e90cbdbdf6d05ea00d6ad7e3</cites><orcidid>0000-0002-3370-6937 ; 0000-0001-5658-5077</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374104/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374104/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37498831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sato, Yasunori</contributor><creatorcontrib>Lee, Young-Jin</creatorcontrib><creatorcontrib>Yoo, Tae-Kyung</creatorcontrib><creatorcontrib>Kim, Jisun</creatorcontrib><creatorcontrib>Chung, Il Yong</creatorcontrib><creatorcontrib>Ko, Beom Seok</creatorcontrib><creatorcontrib>Kim, Hee Jeong</creatorcontrib><creatorcontrib>Lee, Jong Won</creatorcontrib><creatorcontrib>Son, Byung Ho</creatorcontrib><creatorcontrib>Ahn, Sei-Hyun</creatorcontrib><creatorcontrib>Lee, Sae Byul</creatorcontrib><title>Survival outcomes of breast cancer patients with recurrence after surgery according to period and subtype</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To analyze and compare the survival rates of recurrent breast cancer patients in Korea between two periods (period I: 2000-2007; period II: 2008-2013) and to identify the factors associated with outcomes and changes over time in the duration of survival after recurrence.
We retrospectively analyzed 2,407 patients who had recurrent breast cancer with treated between January 2000 and December 2013 and divided them into two periods according to the year of recurrence. We reviewed the age at diagnosis, clinical manifestations, pathology report, surgical methods, types of adjuvant treatment, type of recurrence, and follow-up period.
The median follow-up was 30.6 months (range, 0-223.4) from the time of relapse, and the median survival time was 42.3 months. Survival after recurrence (SAR) significantly improved from 38.0 months in period I to 49.7 months in period II (p < 0.001). In the analysis performed according to the hormone receptor and HER2 status subtypes, all subtypes except the triple-negative subtype showed higher SAR in period II than period I. Age at diagnosis, tumor stage, and treatment after recurrence were significantly correlated with survival outcomes.
The survival outcomes of Korean patients with breast cancer after the first recurrence have improved in Korea. Such improvements may be attributed to advances in treatment.</description><subject>Biology and Life Sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer patients</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Disease-Free Survival</subject><subject>Diseases</subject><subject>ErbB-2 protein</subject><subject>Ethics</subject><subject>Female</subject><subject>Humans</subject><subject>Korea</subject><subject>Lymphatic system</subject><subject>Mammography</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Metastasis</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Receptor, ErbB-2</subject><subject>Receptors, Progesterone</subject><subject>Regression analysis</subject><subject>Relapse</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Tomography</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwDxBYQkJw2MWJHTs5oario1KlShS4Wo49ybpy4tR2Fvbf46VptUE9IB888jwzY79-s-xljtc54fmHazf5Qdr16AZY46KilOFH2XFek2LFCkweH8RH2bMQrjEuScXY0-yIcFpXFcmPM3M1-a3ZSovcFJXrISDXosaDDBEpOSjwaJTRwBAD-mXiBnlQk_eQMki2MaXD5DvwOySVcl6boUPRoRG8cRrJQad8E3cjPM-etNIGeDHvJ9mPz5--n31dXVx-OT87vVipkrO4IqBYThSjWvOqrTEtKigprVKsNPBalrwEqFUBNVaNbnTLNC5BYqyZ1BzISfb6tu9oXRCzSkEkgYqa4qrmifg4E1PTg1bpbV5aMXrTS78TThqxzAxmIzq3FTlOwuWYpg7v5g7e3UwQouhNUGCtHMBNf4dRXPOC5wl98w_68JVmqpMWhBlalwarfVNxysuKEUZZmaj1A1RaGnqjkg9ak84XBe8XBYmJ8Dt2cgpBnF99-3_28ueSfXvAbkDauAnOTtG4ISxBegsq70Lw0N6rnGOxt_GdGmJvYzHbOJW9Ovyh-6I735I_umLv7Q</recordid><startdate>20230727</startdate><enddate>20230727</enddate><creator>Lee, Young-Jin</creator><creator>Yoo, Tae-Kyung</creator><creator>Kim, Jisun</creator><creator>Chung, Il Yong</creator><creator>Ko, Beom Seok</creator><creator>Kim, Hee Jeong</creator><creator>Lee, Jong Won</creator><creator>Son, Byung Ho</creator><creator>Ahn, Sei-Hyun</creator><creator>Lee, Sae Byul</creator><general>Public Library of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3370-6937</orcidid><orcidid>https://orcid.org/0000-0001-5658-5077</orcidid></search><sort><creationdate>20230727</creationdate><title>Survival outcomes of breast cancer patients with recurrence after surgery according to period and subtype</title><author>Lee, Young-Jin ; Yoo, Tae-Kyung ; Kim, Jisun ; Chung, Il Yong ; Ko, Beom Seok ; Kim, Hee Jeong ; Lee, Jong Won ; Son, Byung Ho ; Ahn, Sei-Hyun ; Lee, Sae Byul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-3ec613c64dd78f90428e54488f9cde79a575ee9c2e90cbdbdf6d05ea00d6ad7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biology and Life Sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Young-Jin</au><au>Yoo, Tae-Kyung</au><au>Kim, Jisun</au><au>Chung, Il Yong</au><au>Ko, Beom Seok</au><au>Kim, Hee Jeong</au><au>Lee, Jong Won</au><au>Son, Byung Ho</au><au>Ahn, Sei-Hyun</au><au>Lee, Sae Byul</au><au>Sato, Yasunori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival outcomes of breast cancer patients with recurrence after surgery according to period and subtype</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-07-27</date><risdate>2023</risdate><volume>18</volume><issue>7</issue><spage>e0284460</spage><epage>e0284460</epage><pages>e0284460-e0284460</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To analyze and compare the survival rates of recurrent breast cancer patients in Korea between two periods (period I: 2000-2007; period II: 2008-2013) and to identify the factors associated with outcomes and changes over time in the duration of survival after recurrence.
We retrospectively analyzed 2,407 patients who had recurrent breast cancer with treated between January 2000 and December 2013 and divided them into two periods according to the year of recurrence. We reviewed the age at diagnosis, clinical manifestations, pathology report, surgical methods, types of adjuvant treatment, type of recurrence, and follow-up period.
The median follow-up was 30.6 months (range, 0-223.4) from the time of relapse, and the median survival time was 42.3 months. Survival after recurrence (SAR) significantly improved from 38.0 months in period I to 49.7 months in period II (p < 0.001). In the analysis performed according to the hormone receptor and HER2 status subtypes, all subtypes except the triple-negative subtype showed higher SAR in period II than period I. Age at diagnosis, tumor stage, and treatment after recurrence were significantly correlated with survival outcomes.
The survival outcomes of Korean patients with breast cancer after the first recurrence have improved in Korea. Such improvements may be attributed to advances in treatment.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37498831</pmid><doi>10.1371/journal.pone.0284460</doi><tpages>e0284460</tpages><orcidid>https://orcid.org/0000-0002-3370-6937</orcidid><orcidid>https://orcid.org/0000-0001-5658-5077</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Biology and Life Sciences Breast cancer Breast Neoplasms - pathology Cancer patients Cancer therapies Care and treatment Chemotherapy Diagnosis Disease Disease-Free Survival Diseases ErbB-2 protein Ethics Female Humans Korea Lymphatic system Mammography Medical diagnosis Medical prognosis Medicine and Health Sciences Metastasis Neoplasm Recurrence, Local - pathology Patient outcomes Patients Prognosis Radiation therapy Receptor, ErbB-2 Receptors, Progesterone Regression analysis Relapse Retrospective Studies Surgery Survival Survival Rate Tomography |
| title | Survival outcomes of breast cancer patients with recurrence after surgery according to period and subtype |
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