Dysregulated metabolism of the late herpes simplex virus 1 transcriptome through the vhs-VP22 axis uncouples virus cytopathic effect and virus production

Herpes simplex virus 1 (HSV1) expresses its genes in a classical cascade culminating in the production of large amounts of structural proteins to facilitate virus assembly. HSV1 lacking the virus protein VP22 (Δ22) exhibits late translational shutoff, a phenotype that has been attributed to the unre...

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Veröffentlicht in:	PLoS pathogens 2023-06, Vol.19 (6), p.e1010966-e1010966
Hauptverfasser:	Pheasant, Kathleen, Perry, Dana, Wise, Emma L, Cheng, Vivian, Elliott, Gillian
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biology and life sciences Control Cytoplasm Degradation Fibroblasts Gene expression Gene mutations Genomes Glycoproteins Health aspects Herpes simplex Herpes simplex virus Herpes viruses Identification and classification Infections Kinases Localization Medicine and Health Sciences Messenger RNA Metabolism Mutation Phenotypes Protein biosynthesis Protein synthesis Proteins Research and Analysis Methods Structural proteins Transcriptomes Virions Viruses VP22 protein
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