A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain
Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2023-06, Vol.17 (6), p.e0011394-e0011394 |
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| container_title | PLoS neglected tropical diseases |
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| creator | Muhi, Stephen Osowicki, Joshua O'Brien, Daniel Johnson, Paul D R Pidot, Sacha Doerflinger, Marcel Marshall, Julia L Pellegrini, Marc McCarthy, James Stinear, Timothy P |
| description | Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain. |
| doi_str_mv | 10.1371/journal.pntd.0011394 |
| format | Article |
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Here, we review the current understanding of host-pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0011394</identifier><identifier>PMID: 37384606</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antibiotics ; Biology and Life Sciences ; Buruli ulcer ; Climate change ; Cytokines ; Diagnosis ; Granulomas ; Health aspects ; Host-pathogen interactions ; Infections ; Investigations ; Medicine and Health Sciences ; Mycobacteria ; Mycobacterium ; Mycobacterium ulcerans ; Pathogenesis ; Pathogens ; Research and Analysis Methods ; Review ; Risk factors ; Strain ; Surgery ; Tropical diseases ; Ulcers ; Vaccines</subject><ispartof>PLoS neglected tropical diseases, 2023-06, Vol.17 (6), p.e0011394-e0011394</ispartof><rights>Copyright: © 2023 Muhi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Muhi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.</description><subject>Antibiotics</subject><subject>Biology and Life Sciences</subject><subject>Buruli ulcer</subject><subject>Climate change</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>Granulomas</subject><subject>Health aspects</subject><subject>Host-pathogen interactions</subject><subject>Infections</subject><subject>Investigations</subject><subject>Medicine and Health Sciences</subject><subject>Mycobacteria</subject><subject>Mycobacterium</subject><subject>Mycobacterium ulcerans</subject><subject>Pathogenesis</subject><subject>Pathogens</subject><subject>Research and Analysis Methods</subject><subject>Review</subject><subject>Risk factors</subject><subject>Strain</subject><subject>Surgery</subject><subject>Tropical 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| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Antibiotics Biology and Life Sciences Buruli ulcer Climate change Cytokines Diagnosis Granulomas Health aspects Host-pathogen interactions Infections Investigations Medicine and Health Sciences Mycobacteria Mycobacterium Mycobacterium ulcerans Pathogenesis Pathogens Research and Analysis Methods Review Risk factors Strain Surgery Tropical diseases Ulcers Vaccines |
| title | A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain |
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