Metabolic and inflammatory profiles, gut microbiota and lifestyle factors in overweight and normal weight young thai adults
Obesity among young adults, especially those living in developing countries is increasing. A high body mass index (BMI) is one of the major causes of several diseases worldwide, constituting an important risk factor for non-communicable diseases (NCDs). Investigations describing the relationship bet...
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| description | Obesity among young adults, especially those living in developing countries is increasing. A high body mass index (BMI) is one of the major causes of several diseases worldwide, constituting an important risk factor for non-communicable diseases (NCDs). Investigations describing the relationship between BMI, clinical and gut microbiota characteristics and lifestyle factors of overweight young adults, especially from Southeast Asian countries are limited. Metabolic and inflammatory biomarkers, fecal microbiota profiles and lifestyle factors were compared between overweight Thai young adults (n = 30, mean age 33 ± 9.48) and those with normal weight (n = 30, mean age 27 ±7.50). This study was registered with the Thai Clinical Trials Registry (TCTR20220204007). Health status including body composition, fasting glucose and insulin, lipid profiles, liver and kidney function, inflammatory biomarkers, blood pressure and fecal microbiota using 16S rRNA gene sequencing data was determined. Dietary intake was assessed using a 3-day dietary record and a food frequency questionnaire (FFQ), with physical activity levels compared using the international physical activity questionnaire (IPAQ). The overweight group had significantly higher BMI, waist-hip ratio, body fat mass, % body fat, skeletal mass, triglyceride level, C-reactive protein, insulin and blood pressure, with lower levels of high-density lipoprotein cholesterol (HDL-C) and blood urea nitrogen compared to the normal weight group. Significant differences in fecal microbiota composition at the family and genus levels were observed between the two groups. In our clinical setting, we also observed that unhealthy diets with high consumption of food rich in fat and sugar, processed meat and alcohol, and physical inactivity were associated with an increased prevalence of overweight in Thai young adults. Results provided the big picture of health and lifestyle characteristics of overweight young Thai people. Young adults should be encouraged to engage in health-promoting activities that maintain healthy bodyweight. |
| doi_str_mv | 10.1371/journal.pone.0288286 |
| format | Article |
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A high body mass index (BMI) is one of the major causes of several diseases worldwide, constituting an important risk factor for non-communicable diseases (NCDs). Investigations describing the relationship between BMI, clinical and gut microbiota characteristics and lifestyle factors of overweight young adults, especially from Southeast Asian countries are limited. Metabolic and inflammatory biomarkers, fecal microbiota profiles and lifestyle factors were compared between overweight Thai young adults (n = 30, mean age 33 ± 9.48) and those with normal weight (n = 30, mean age 27 ±7.50). This study was registered with the Thai Clinical Trials Registry (TCTR20220204007). Health status including body composition, fasting glucose and insulin, lipid profiles, liver and kidney function, inflammatory biomarkers, blood pressure and fecal microbiota using 16S rRNA gene sequencing data was determined. Dietary intake was assessed using a 3-day dietary record and a food frequency questionnaire (FFQ), with physical activity levels compared using the international physical activity questionnaire (IPAQ). The overweight group had significantly higher BMI, waist-hip ratio, body fat mass, % body fat, skeletal mass, triglyceride level, C-reactive protein, insulin and blood pressure, with lower levels of high-density lipoprotein cholesterol (HDL-C) and blood urea nitrogen compared to the normal weight group. Significant differences in fecal microbiota composition at the family and genus levels were observed between the two groups. In our clinical setting, we also observed that unhealthy diets with high consumption of food rich in fat and sugar, processed meat and alcohol, and physical inactivity were associated with an increased prevalence of overweight in Thai young adults. Results provided the big picture of health and lifestyle characteristics of overweight young Thai people. Young adults should be encouraged to engage in health-promoting activities that maintain healthy bodyweight.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0288286</identifier><identifier>PMID: 37450433</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Analysis ; Biology and Life Sciences ; Biomarkers ; Blood pressure ; Body composition ; Body fat ; Body mass ; Body Mass Index ; Body size ; Body weight ; C-reactive protein ; Cholesterol ; Clinical trials ; Composition ; Developing countries ; Development and progression ; Diet ; Dietary intake ; Exercise ; Fecal microflora ; Food ; Food consumption ; Food habits ; Food intake ; Gastrointestinal Microbiome - genetics ; Gene sequencing ; Health aspects ; Health promotion ; Health risks ; High density lipoprotein ; Humans ; Inflammation ; Influence ; Insulin ; Intestinal microflora ; LDCs ; Life Style ; Lipids ; Medicine and Health Sciences ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Obesity ; Overweight ; Overweight - epidemiology ; People and Places ; Physical activity ; Questionnaires ; Risk factors ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Southeast Asian People ; Triglycerides ; Urea ; Young Adult ; Young adults</subject><ispartof>PloS one, 2023-07, Vol.18 (7), p.e0288286</ispartof><rights>Copyright: © 2023 Somnuk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Somnuk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Somnuk et al 2023 Somnuk et al</rights><rights>2023 Somnuk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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A high body mass index (BMI) is one of the major causes of several diseases worldwide, constituting an important risk factor for non-communicable diseases (NCDs). Investigations describing the relationship between BMI, clinical and gut microbiota characteristics and lifestyle factors of overweight young adults, especially from Southeast Asian countries are limited. Metabolic and inflammatory biomarkers, fecal microbiota profiles and lifestyle factors were compared between overweight Thai young adults (n = 30, mean age 33 ± 9.48) and those with normal weight (n = 30, mean age 27 ±7.50). This study was registered with the Thai Clinical Trials Registry (TCTR20220204007). Health status including body composition, fasting glucose and insulin, lipid profiles, liver and kidney function, inflammatory biomarkers, blood pressure and fecal microbiota using 16S rRNA gene sequencing data was determined. Dietary intake was assessed using a 3-day dietary record and a food frequency questionnaire (FFQ), with physical activity levels compared using the international physical activity questionnaire (IPAQ). The overweight group had significantly higher BMI, waist-hip ratio, body fat mass, % body fat, skeletal mass, triglyceride level, C-reactive protein, insulin and blood pressure, with lower levels of high-density lipoprotein cholesterol (HDL-C) and blood urea nitrogen compared to the normal weight group. Significant differences in fecal microbiota composition at the family and genus levels were observed between the two groups. In our clinical setting, we also observed that unhealthy diets with high consumption of food rich in fat and sugar, processed meat and alcohol, and physical inactivity were associated with an increased prevalence of overweight in Thai young adults. Results provided the big picture of health and lifestyle characteristics of overweight young Thai people. Young adults should be encouraged to engage in health-promoting activities that maintain healthy bodyweight.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37450433</pmid><doi>10.1371/journal.pone.0288286</doi><tpages>e0288286</tpages><orcidid>https://orcid.org/0000-0002-6987-182X</orcidid><orcidid>https://orcid.org/0000-0003-1593-9734</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2837326120 |
| source | MEDLINE; Public Library of Science; Full-Text Journals in Chemistry (Open access); DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Adult Adults Analysis Biology and Life Sciences Biomarkers Blood pressure Body composition Body fat Body mass Body Mass Index Body size Body weight C-reactive protein Cholesterol Clinical trials Composition Developing countries Development and progression Diet Dietary intake Exercise Fecal microflora Food Food consumption Food habits Food intake Gastrointestinal Microbiome - genetics Gene sequencing Health aspects Health promotion Health risks High density lipoprotein Humans Inflammation Influence Insulin Intestinal microflora LDCs Life Style Lipids Medicine and Health Sciences Microbiota Microbiota (Symbiotic organisms) Microorganisms Obesity Overweight Overweight - epidemiology People and Places Physical activity Questionnaires Risk factors RNA, Ribosomal, 16S - genetics rRNA 16S Southeast Asian People Triglycerides Urea Young Adult Young adults |
| title | Metabolic and inflammatory profiles, gut microbiota and lifestyle factors in overweight and normal weight young thai adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T17%3A05%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolic%20and%20inflammatory%20profiles,%20gut%20microbiota%20and%20lifestyle%20factors%20in%20overweight%20and%20normal%20weight%20young%20thai%20adults&rft.jtitle=PloS%20one&rft.au=Somnuk,%20Surasawadee&rft.date=2023-07-14&rft.volume=18&rft.issue=7&rft.spage=e0288286&rft.pages=e0288286-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0288286&rft_dat=%3Cgale_plos_%3EA757145327%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2837326120&rft_id=info:pmid/37450433&rft_galeid=A757145327&rfr_iscdi=true |